(1)  Duke @  Georgia Tech | 0:00 | ACC Network |
(3)  Marquette @  Xavier | 11:00 AM | FOX |
 North Florida @ (3)  Florida | 11:00 AM | SEC Network |
(4)  Connecticut @  Butler | 11:00 AM | Peacock |
(6)  Maryland v.  Syracuse | 11:00 AM | ESPN2 |
(11)  Penn State @  Drexel | 11:00 AM | |
 Chattanooga @ (FFO)  Indiana | 11:00 AM | BTN |
(FFO)  SMU @  Boston College | 11:00 AM | |
(6)  Mississippi State @ (5)  Memphis | 11:30 AM | |
 Sam Houston State @ (6)  Pittsburgh | 12:00 PM | ACC Extra |
 Lamar @ (10)  Texas Tech | 12:00 PM | ESPN+ |
 Texas A&M-Corpus Christi @ (3)  Houston | 1:00 PM | CBSSN |
 FAU @ (5)  Michigan State | 1:00 PM | FS1 |
(FFO)  Louisville @  Florida State | 1:00 PM | |
 UTA @ (12)  Liberty | 1:00 PM | ESPN+ |
 Wake Forest @ (7)  Clemson | 1:30 PM | ESPN |
 North Carolina A&T @ (10)  Arkansas | 1:30 PM | SEC Network |
(12)  UC Irvine @  Duquesne | 1:30 PM | ESPN+ |
(5)  UCLA v. (8)  North Carolina | 2:00 PM | CBS |
 Air Force @ (FFO)  Boise State | 2:30 PM | |
 Central Michigan @ (8)  Arizona | 3:00 PM | ESPN+ |
(11)  Arizona State @  UMass | 3:00 PM | |
 Villanova @ (NFO)  Creighton | 3:00 PM | FS1 |
 DePaul @ (NFO)  Northwestern | 3:00 PM | BTN |
(1)  Auburn v. (4)  Purdue | 3:30 PM | ESPN |
(2)  Kentucky v. (10)  Ohio State | 4:30 PM | CBS |
(11)  Iowa v.  Utah | 5:00 PM | BTN |
 Green Bay @ (12)  Drake | 5:00 PM | ESPN+ |
 Queens @ (8)  Ole Miss | 6:00 PM | SECN+ |
(3)  Oregon v.  Stanford | 7:00 PM | BTN |
 Bucknell @ (2)  Gonzaga | 8:00 PM | ESPN+ |
(9)  San Diego State v.  California | 9:30 PM | ACC Network |
 Morgan State @ (1)  Iowa State | 12:00 PM | ESPN+ |
(14)  Kent State @ (2)  Alabama | 12:00 PM | SEC Network |
(5)  Illinois v. (NFO)  Missouri | 12:00 PM | ESPN |
(15)  Purdue Fort Wayne @ (7)  Michigan | 12:00 PM | BTN+ |
 Central Arkansas @ (8)  Oklahoma | 12:00 PM | SEC Network |
 Detroit @ (7)  Wisconsin | 1:00 PM | BTN |
 Mercyhurst @ (9)  West Virginia | 1:00 PM | ESPN+ |
 Grambling State @ (9)  Cincinnati | 1:00 PM | ESPN+ |
 Brown @ (2)  Kansas | 2:00 PM | ESPN |
(12)  McNeese @  Louisiana | 2:00 PM | |
 Charleston Southern @ (10)  Georgia | 2:30 PM | SEC Network |
(11)  Utah State @ (9)  Saint Mary's College | 7:00 PM | ESPN+ |
(11)  Nebraska v.  Murray State | 8:00 PM | ESPN2 |
| (2) Gonzaga v. (5) UCLA | 0:00 | FOX |
| (11) Utah State @ (9) San Diego State | 0:00 | |
(FFO) Boise State @  San Jose State | 0:00 | |
 Maryland Eastern Shore @ (6) Maryland | 11:00 AM | BTN |
 Eastern Kentucky @ (FFO) Louisville | 11:00 AM | |
| (8) Ole Miss @ (5) Memphis | 1:00 PM | ESPN2 |
 Longwood @ (FFO) SMU | 1:00 PM | ACC Extra |
 Abilene Christian @ (4)  Texas A&M | 3:00 PM | SEC Network |
 New Orleans @ (12) McNeese | 4:00 PM | ESPN+ |
 Delaware @ (6)  Saint John's | 5:00 PM | FS1 |
 Pacific @ (9) Saint Mary's College | 7:00 PM | ESPN+ |
 South Dakota State @ (2) Alabama | 0:00 | SECN+ |
 Northwestern State @ (11)  Texas | 0:00 | SECN+ |
 Indiana State @ (10) Ohio State | 11:00 AM | BTN |
 Stetson @ (3) Florida | 12:00 PM | SECN+ |
 Penn @ (11) Penn State | 12:00 PM | Peacock |
 Northeastern @ (NFO) Northwestern | 12:30 PM | Peacock |
 Chicago State @ (5) Illinois | 1:00 PM | BTN |
 Prairie View A&M @ (8) Oklahoma | 1:00 PM | SECN+ |
 South Carolina State @ (10) Georgia | 1:00 PM | SECN+ |
 Belmont @ (12) Drake | 1:00 PM | ESPN+ |
 Winthrop @ (FFO) Indiana | 3:00 PM | BTN |
 Weber State @ (3) Oregon | 4:00 PM | BTN+ |
 Toledo @ (4) Purdue | 5:00 PM | BTN |
 Western Kentucky @ (7) Michigan | 7:00 PM | BTN |
 Campbell @ (8) North Carolina | 7:00 PM | ACC Network |
 Western Michigan @ (5) Michigan State | 2:00 PM | BTN |
 Monmouth @ (1) Auburn | 5:30 PM | SECN+ |
(9) Cincinnati @  Kansas State | 6:00 PM | ESPN+ |
 New Hampshire @ (11) Iowa | 6:00 PM | BTN |
 Southeastern Louisiana @ (12) McNeese | 6:00 PM | |
 Alabama State @ (NFO) Missouri | 6:30 PM | SECN+ |
(3) Houston @  Oklahoma State | 7:00 PM | ESPN+ |
 TCU @ (8) Arizona | 7:00 PM | ESPN+ |
 Oakland @ (10) Arkansas | 7:00 PM | ESPNU |
(1) Iowa State @  Colorado | 8:00 PM | CBSSN |
 Bethune-Cookman @ (6) Mississippi State | 8:00 PM | SEC Network |
(16)  Southern @ (11) Nebraska | 8:00 PM | BTN |
(2) Gonzaga @  Pepperdine | 9:00 PM | ESPN+ |
(12) UC Irvine @  California Baptist | 9:00 PM | ESPN+ |
(2) Gonzaga @  Loyola-Marymount | 0:00 | |
(9) Saint Mary's College @  Portland | 0:00 | |
| (3) Florida @ (2) Kentucky | 10:00 AM | ESPN |
(7)  Dayton @  George Washington | 11:00 AM | |
| (10) Georgia @ (8) Ole Miss | 11:00 AM | SEC Network |
(8) North Carolina @  Notre Dame | 11:00 AM | |
| Oklahoma State @ (9) West Virginia | 11:00 AM | CBSSN |
(10) Arkansas @ (1)  Tennessee | 12:00 PM | ESPN |
(4)  Baylor @ (1) Iowa State | 1:00 PM | CBS |
(NFO)  BYU @ (3) Houston | 1:00 PM | ESPN+ |
| (5) UCLA @ (11) Nebraska | 1:00 PM | FOX |
 South Carolina @ (6) Mississippi State | 1:00 PM | SEC Network |
| Butler @ (6) Saint John's | 1:00 PM | FS1 |
| (1) Duke @ (FFO) SMU | 1:15 PM | |
| (8) Arizona @ (9) Cincinnati | 1:30 PM | ESPN2 |
(12) McNeese @  East Texas A&M | 2:15 PM | |
| (NFO) Missouri @ (1) Auburn | 3:00 PM | SEC Network |
| (9) San Diego State @ (FFO) Boise State | 3:00 PM | |
(FFO) Louisville @  Virginia | 3:00 PM | ACC Network |
| (8) Oklahoma @ (2) Alabama | 5:00 PM | SEC Network |
| Colorado @ (11) Arizona State | 5:00 PM | ESPN+ |
 Middle Tennessee @ (12) Liberty | 5:00 PM | CBSSN |
| Stanford @ (6) Pittsburgh | 5:30 PM | ESPN2 |
| (10) Texas Tech @ Utah | 6:00 PM | ESPN+ |
| (11) Texas @ (4) Texas A&M | 7:00 PM | SEC Network |
(7) Michigan @  USC | 7:00 PM | FOX |
| California @ (7) Clemson | 7:30 PM | ESPN2 |
 Fresno State @ (11) Utah State | 8:00 PM | |
 UC Riverside @ (12) UC Irvine | 9:00 PM | |
| (11) Utah State @ San Jose State | 0:00 | |
| (6) Saint John's @ Xavier | 5:30 PM | FS1 |
| (1) Tennessee @ (3) Florida | 6:00 PM | |
| (6) Pittsburgh @ (1) Duke | 6:00 PM | ESPN |
| (2) Kentucky @ (10) Georgia | 6:00 PM | SEC Network |
| (7) Clemson @ (FFO) Louisville | 6:00 PM | |
| (8) Arizona @ (9) West Virginia | 6:00 PM | ESPN+ |
| Utah @ (1) Iowa State | 7:00 PM | ESPN+ |
 Georgetown @ (3) Marquette | 7:00 PM | CBSSN |
| (9) Cincinnati @ (4) Baylor | 7:00 PM | ESPN+ |
| (11) Nebraska @ (11) Iowa | 7:00 PM | Peacock |
| (1) Auburn @ (11) Texas | 8:00 PM | |
(6) Mississippi State @  Vanderbilt | 8:00 PM | |
| (FFO) SMU @ (8) North Carolina | 8:00 PM | ACC Network |
| (10) Texas Tech @ (NFO) BYU | 8:00 PM | ESPN+ |
 LSU @ (NFO) Missouri | 8:00 PM | SEC Network |
| (7) Michigan @ (5) UCLA | 9:00 PM | Peacock |
 UNLV @ (FFO) Boise State | 9:30 PM | |
| Loyola-Marymount @ (9) Saint Mary's College | 10:00 PM | ESPN2 |
(9) Saint Mary's College @  San Diego | 0:00 | |
(9) San Diego State @  New Mexico | 0:00 | |
| Notre Dame @ (1) Duke | 11:00 AM | ESPN |
| USC @ (5) Illinois | 11:00 AM | BTN |
| (FFO) Louisville @ (6) Pittsburgh | 11:00 AM | ESPN2 |
| (NFO) Creighton @ Butler | 11:00 AM | FOX |
| (1) Auburn @ South Carolina | 12:00 PM | SEC Network |
| (1) Iowa State @ (10) Texas Tech | 1:00 PM | |
| (2) Kansas @ (9) Cincinnati | 1:00 PM | ESPN+ |
| (4) Connecticut @ Georgetown | 1:00 PM | |
 East Carolina @ (5) Memphis | 1:00 PM | |
| Florida State @ (7) Clemson | 1:00 PM | ACC Network |
| (NFO) BYU @ TCU | 1:00 PM | |
| Vanderbilt @ (NFO) Missouri | 2:30 PM | SEC Network |
| (3) Florida @ (10) Arkansas | 3:00 PM | |
(8) North Carolina @  North Carolina State | 3:00 PM | ACC Network |
| Georgia Tech @ (FFO) SMU | 3:00 PM | |
 Nicholls @ (12) McNeese | 4:00 PM | |
| (1) Tennessee @ (11) Texas | 5:00 PM | |
| (3) Houston @ Kansas State | 5:00 PM | ESPN+ |
| (8) Oklahoma @ (10) Georgia | 5:00 PM | |
| LSU @ (8) Ole Miss | 5:00 PM | SEC Network |
 Evansville @ (12) Drake | 5:00 PM | |
| Villanova @ (6) Saint John's | 6:00 PM | CBSSN |
| (2) Alabama @ (4) Texas A&M | 7:00 PM | |
| (FFO) Indiana @ (11) Iowa | 7:00 PM | FOX |
(12) Liberty @  Louisiana Tech | 7:00 PM | ESPNU |
| (2) Kentucky @ (6) Mississippi State | 7:30 PM | SEC Network |
 Washington State @ (2) Gonzaga | 8:00 PM | |
| (FFO) Boise State @ (11) Utah State | 8:00 PM | |
| (4) Baylor @ (11) Arizona State | 8:30 PM | ESPN+ |
 UCF @ (8) Arizona | 9:00 PM | ESPN |
(12) UC Irvine @  UC San Diego | 9:00 PM | |
| (6) Mississippi State @ (1) Auburn | 6:00 PM | SEC Network |
| (8) Ole Miss @ (2) Alabama | 6:00 PM | |
| (4) Texas A&M @ (2) Kentucky | 6:00 PM | |
| (3) Marquette @ DePaul | 6:00 PM | CBSSN |
| (5) Illinois @ (FFO) Indiana | 6:00 PM | Peacock |
| (FFO) Louisville @ Syracuse | 6:00 PM | ACC Network |
| Georgetown @ (6) Saint John's | 6:30 PM | Peacock |
 Providence @ (NFO) Creighton | 7:30 PM | FS1 |
 Miami (FL) @ (1) Duke | 8:00 PM | ESPN |
| (NFO) Missouri @ (3) Florida | 8:00 PM | ESPNU |
| (7) Clemson @ Georgia Tech | 8:00 PM | ACC Network |
| (10) Ohio State @ (7) Wisconsin | 8:00 PM | Peacock |
| (10) Texas Tech @ Kansas State | 8:00 PM | CBSSN |
| (10) Arkansas @ LSU | 8:00 PM | SEC Network |
 Wyoming @ (FFO) Boise State | 8:00 PM | |
| Oklahoma State @ (NFO) BYU | 8:00 PM | ESPN+ |
| (11) Iowa @ USC | 9:30 PM | FS1 |
| (4) Baylor @ (8) Arizona | 10:00 PM | ESPN |
 Colorado State @ (9) San Diego State | 10:00 PM | |
| UCF @ (11) Arizona State | 10:00 PM | ESPNU |
| (2) Kansas @ (1) Iowa State | 6:00 PM | ESPN2 |
 George Mason @ (7) Dayton | 6:00 PM | |
| California @ (8) North Carolina | 6:00 PM | ACC Network |
| (11) Penn State @ (5) Michigan State | 6:30 PM | BTN |
| (10) Georgia @ (1) Tennessee | 7:00 PM | SEC Network |
| (9) West Virginia @ (3) Houston | 7:00 PM | ESPN+ |
| (6) Pittsburgh @ Florida State | 8:00 PM | ESPNU |
| (9) Cincinnati @ Colorado | 8:00 PM | ESPN+ |
| (FFO) SMU @ Virginia | 8:00 PM | ACC Network |
 Illinois State @ (12) Drake | 8:00 PM | |
(4) Purdue @  Washington | 8:30 PM | BTN |
| (11) Texas @ (8) Oklahoma | 9:00 PM | SEC Network |
| (11) Utah State @ UNLV | 10:00 PM | |
| (1) Duke @ Boston College | 0:00 | |
| (11) Texas @ (3) Florida | 0:00 | |
| (8) Ole Miss @ (6) Mississippi State | 0:00 | |
| South Carolina @ (8) Oklahoma | 0:00 | |
| (8) Arizona @ (10) Texas Tech | 0:00 | |
| (9) Saint Mary's College @ Pepperdine | 0:00 | |
| Virginia @ (FFO) Louisville | 0:00 | |
| (FFO) SMU @ Miami (FL) | 0:00 | |
| (12) Drake @ Indiana State | 0:00 | |
| (2) Alabama @ (2) Kentucky | 11:00 AM | ESPN |
| (3) Houston @ UCF | 11:00 AM | CBSSN |
| (NFO) Creighton @ (4) Connecticut | 11:00 AM | FOX |
| (7) Clemson @ (6) Pittsburgh | 11:00 AM | |
| (1) Auburn @ (10) Georgia | 12:00 PM | SEC Network |
| Kansas State @ (2) Kansas | 12:00 PM | CBS |
| Xavier @ (3) Marquette | 1:00 PM | FOX |
| (11) Arizona State @ (9) Cincinnati | 1:00 PM | CBSSN |
| Stanford @ (8) North Carolina | 1:15 PM | |
| (4) Purdue @ (3) Oregon | 2:00 PM | NBC |
| (7) Wisconsin @ USC | 2:00 PM | BTN |
| (1) Tennessee @ Vanderbilt | 2:30 PM | SEC Network |
 Loyola-Chicago @ (7) Dayton | 3:00 PM | |
| (1) Iowa State @ (9) West Virginia | 4:00 PM | ESPN+ |
| Lamar @ (12) McNeese | 4:00 PM | |
| (10) Arkansas @ (NFO) Missouri | 5:00 PM | SEC Network |
 New Mexico State @ (12) Liberty | 6:00 PM | ESPN+ |
(6) Saint John's @  Seton Hall | 7:00 PM | |
| UNLV @ (9) San Diego State | 7:00 PM | |
| LSU @ (4) Texas A&M | 7:30 PM | SEC Network |
 Santa Clara @ (2) Gonzaga | 8:00 PM | |
| (NFO) BYU @ Utah | 8:00 PM | ESPN+ |
 Cal Poly @ (12) UC Irvine | 9:00 PM | |
| (6) Mississippi State @ (1) Tennessee | 6:00 PM | |
| Vanderbilt @ (2) Alabama | 6:00 PM | SEC Network |
| Butler @ (4) Connecticut | 6:00 PM | FS1 |
| (7) Dayton @ Duquesne | 6:00 PM | |
| (10) Texas Tech @ (9) Cincinnati | 6:00 PM | |
| (10) Ohio State @ (4) Purdue | 6:30 PM | Peacock |
| UCF @ (1) Iowa State | 7:00 PM | ESPN+ |
| (3) Marquette @ Seton Hall | 7:00 PM | Peacock |
| Utah @ (3) Houston | 7:00 PM | ESPN+ |
| (8) Arizona @ Oklahoma State | 8:00 PM | ESPNU |
| (8) North Carolina @ Wake Forest | 8:00 PM | ESPN |
| (11) Arizona State @ (9) West Virginia | 8:00 PM | CBSSN |
| (NFO) Missouri @ (11) Texas | 8:00 PM | SEC Network |
 Minnesota @ (11) Iowa | 8:00 PM | BTN |
| (FFO) Louisville @ (FFO) SMU | 8:00 PM | ACC Network |
| (NFO) Creighton @ DePaul | 8:00 PM | FS1 |
| (7) Wisconsin @ (5) UCLA | 8:30 PM | Peacock |
| Washington @ (3) Oregon | 10:00 PM | BTN |
| (NFO) BYU @ Colorado | 10:00 PM | ESPNU |
| (2) Gonzaga @ Portland | 0:00 | |
| (6) Pittsburgh @ Syracuse | 11:00 AM | |
| (FFO) SMU @ North Carolina State | 11:00 AM | |
| (6) Mississippi State @ South Carolina | 12:00 PM | SEC Network |
(5) Michigan State @  Rutgers | 12:30 PM | CBS |
| Seton Hall @ (NFO) Creighton | 12:30 PM | FS1 |
| (1) Iowa State @ (11) Arizona State | 1:00 PM | ESPN+ |
| Boston College @ (8) North Carolina | 1:15 PM | |
| (2) Kentucky @ Vanderbilt | 1:30 PM | |
| (4) Texas A&M @ (11) Texas | 1:30 PM | |
| Colorado @ (8) Arizona | 2:00 PM | ESPN+ |
| (10) Georgia @ (3) Florida | 2:30 PM | SEC Network |
| (3) Oregon @ Minnesota | 3:00 PM | BTN |
| (11) Utah State @ Air Force | 3:00 PM | |
(12) Drake @  Missouri State | 3:00 PM | |
| (1) Duke @ Wake Forest | 3:30 PM | ESPN |
| (4) Baylor @ Utah | 3:30 PM | |
(7) Clemson @  Virginia Tech | 4:00 PM | ACC Network |
(12) McNeese @  UTRGV | 4:30 PM | |
| (8) Ole Miss @ (NFO) Missouri | 5:00 PM | SEC Network |
| (9) West Virginia @ Kansas State | 5:00 PM | CBSSN |
(12) Liberty @  FIU | 5:00 PM | ESPN+ |
| (3) Houston @ (2) Kansas | 5:30 PM | |
| (4) Connecticut @ Xavier | 7:00 PM | FOX |
| (9) Saint Mary's College @ Washington State | 7:00 PM | |
| (1) Tennessee @ (1) Auburn | 7:30 PM | |
| LSU @ (2) Alabama | 7:30 PM | SEC Network |
| (8) Oklahoma @ (10) Arkansas | 7:30 PM | |
(9) San Diego State @  Nevada | 9:00 PM | |
| (9) Cincinnati @ (NFO) BYU | 9:00 PM | ESPN2 |
 Hawaii @ (12) UC Irvine | 9:00 PM | |
| (6) Saint John's @ Georgetown | 5:30 PM | FS1 |
| (2) Kentucky @ (1) Tennessee | 6:00 PM | ESPN |
| South Carolina @ (10) Georgia | 6:00 PM | SEC Network |
| Wake Forest @ (FFO) Louisville | 6:00 PM | ACC Network |
| UCF @ (2) Kansas | 7:00 PM | ESPN+ |
| Minnesota @ (5) Michigan State | 7:00 PM | Peacock |
(7) Dayton @  Saint Bonaventure | 7:00 PM | |
| (3) Marquette @ Butler | 7:30 PM | FS1 |
| (4) Baylor @ (NFO) BYU | 8:00 PM | |
| (8) Oklahoma @ (4) Texas A&M | 8:00 PM | SEC Network |
| (8) North Carolina @ (6) Pittsburgh | 8:00 PM | ESPN |
| (11) Arizona State @ Colorado | 8:00 PM | ESPN+ |
| (9) Cincinnati @ Utah | 9:00 PM | CBSSN |
 Oregon State @ (2) Gonzaga | 10:00 PM | |
| San Jose State @ (9) San Diego State | 10:00 PM | |
| (10) Georgia @ (2) Alabama | 0:00 | |
(12) Drake @  Southern Illinois | 0:00 | |
| (3) Florida @ (1) Tennessee | 11:00 AM | |
| (6) Pittsburgh @ Wake Forest | 11:00 AM | |
| Providence @ (6) Saint John's | 11:00 AM | CBSSN |
| (NFO) Missouri @ (6) Mississippi State | 12:00 PM | SEC Network |
| (8) Arizona @ (11) Arizona State | 12:00 PM | CBS |
| (NFO) Creighton @ Villanova | 12:00 PM | FOX |
| (7) Clemson @ North Carolina State | 12:30 PM | |
| Kansas State @ (1) Iowa State | 1:00 PM | |
| (7) Wisconsin @ (NFO) Northwestern | 1:00 PM | FS1 |
| (7) Michigan @ Rutgers | 2:30 PM | FOX |
| Vanderbilt @ (8) Oklahoma | 2:30 PM | SEC Network |
| (FFO) Louisville @ Georgia Tech | 2:45 PM | |
| (1) Auburn @ (8) Ole Miss | 3:00 PM | |
| (2) Kansas @ (4) Baylor | 3:00 PM | ESPN |
| Fresno State @ (FFO) Boise State | 3:00 PM | |
| (NFO) BYU @ UCF | 3:00 PM | ESPN+ |
| (12) McNeese @ Nicholls | 3:00 PM | |
| (5) Michigan State @ USC | 3:30 PM | Peacock |
(12) Liberty @  Jacksonville State | 4:00 PM | ESPN+ |
| (10) Texas Tech @ (3) Houston | 5:00 PM | ESPN2 |
| (11) Texas @ LSU | 5:00 PM | SEC Network |
| Stanford @ (FFO) SMU | 5:00 PM | ACC Network |
| (8) North Carolina @ (1) Duke | 5:30 PM | ESPN |
| (4) Connecticut @ (3) Marquette | 7:00 PM | FOX |
| Wyoming @ (9) San Diego State | 7:00 PM | |
| (4) Texas A&M @ South Carolina | 7:30 PM | SEC Network |
| (10) Arkansas @ (2) Kentucky | 8:00 PM | ESPN |
| New Mexico @ (11) Utah State | 8:30 PM | |
 UC Davis @ (12) UC Irvine | 9:00 PM | |
| (2) Gonzaga @ (9) Saint Mary's College | 10:00 PM | ESPN |
 Davidson @ (7) Dayton | 0:00 | |
| (3) Marquette @ (6) Saint John's | 5:30 PM | FS1 |
| (2) Kentucky @ (8) Ole Miss | 6:00 PM | ESPN |
| Vanderbilt @ (3) Florida | 6:00 PM | SEC Network |
| (4) Purdue @ (11) Iowa | 6:00 PM | Peacock |
| Minnesota @ (11) Penn State | 6:00 PM | BTN |
| Oklahoma State @ (3) Houston | 7:00 PM | ESPN+ |
| (12) Drake @ Murray State | 7:00 PM | |
| (11) Utah State @ Wyoming | 7:30 PM | |
| (8) Oklahoma @ (1) Auburn | 8:00 PM | SEC Network |
| (4) Baylor @ (10) Texas Tech | 8:00 PM | ESPN2 |
| Georgia Tech @ (7) Clemson | 8:00 PM | ACC Network |
| (FFO) Indiana @ (7) Wisconsin | 8:00 PM | Peacock |
| USC @ (NFO) Northwestern | 8:00 PM | BTN |
| (5) Michigan State @ (5) UCLA | 9:00 PM | Peacock |
| Kansas State @ (11) Arizona State | 9:00 PM | ESPN+ |
| (8) Arizona @ (NFO) BYU | 10:00 PM | |
| (FFO) Boise State @ UNLV | 10:00 PM | |
| (2) Gonzaga @ Pacific | 0:00 | |
| Indiana State @ (12) Drake | 0:00 | |
| (1) Tennessee @ (8) Oklahoma | 11:00 AM | |
| South Carolina @ (2) Kentucky | 11:00 AM | |
| (3) Oregon @ (5) Michigan State | 11:00 AM | FOX |
| TCU @ (1) Iowa State | 12:00 PM | ESPN+ |
| (7) Michigan @ (FFO) Indiana | 12:00 PM | CBS |
| (7) Wisconsin @ (11) Iowa | 12:00 PM | NBC |
| (11) Texas @ Vanderbilt | 12:00 PM | SEC Network |
| (2) Kansas @ Kansas State | 1:00 PM | ESPN |
| (3) Marquette @ (NFO) Creighton | 1:00 PM | FOX |
| UCF @ (4) Baylor | 1:00 PM | ESPN+ |
| Miami (FL) @ (FFO) Louisville | 1:00 PM | ESPN2 |
| (4) Texas A&M @ (NFO) Missouri | 2:30 PM | SEC Network |
| (3) Florida @ (1) Auburn | 3:00 PM | |
| (3) Houston @ Colorado | 3:00 PM | ESPN+ |
| (11) Penn State @ (5) UCLA | 3:00 PM | BTN |
| (6) Pittsburgh @ (8) North Carolina | 3:00 PM | |
| Utah @ (9) West Virginia | 4:00 PM | ESPN+ |
| Northwestern State @ (12) McNeese | 4:00 PM | |
| (1) Duke @ (7) Clemson | 5:00 PM | ESPN |
| (5) Illinois @ Minnesota | 5:00 PM | BTN |
| (6) Mississippi State @ (10) Georgia | 5:00 PM | SEC Network |
| (NFO) BYU @ (9) Cincinnati | 5:00 PM | ESPN2 |
| Sam Houston State @ (12) Liberty | 6:00 PM | ESPNU |
| (2) Alabama @ (10) Arkansas | 7:00 PM | ESPN |
| (8) Ole Miss @ LSU | 7:30 PM | SEC Network |
| (10) Texas Tech @ (8) Arizona | 9:00 PM | ESPN |
| (9) Saint Mary's College @ Oregon State | 9:00 PM | |
| (9) San Diego State @ Colorado State | 9:00 PM | |
| UC San Diego @ (12) UC Irvine | 9:00 PM | |
| (NFO) Northwestern @ Washington | 9:30 PM | BTN |
| (1) Auburn @ Vanderbilt | 6:00 PM | SEC Network |
| (1) Tennessee @ (2) Kentucky | 6:00 PM | ESPN |
| (1) Iowa State @ UCF | 6:00 PM | ESPN+ |
| (3) Florida @ (6) Mississippi State | 6:00 PM | |
| (4) Purdue @ (7) Michigan | 6:00 PM | Peacock |
| (NFO) BYU @ (9) West Virginia | 6:00 PM | CBSSN |
| Utah @ (9) Cincinnati | 6:00 PM | ESPN+ |
| (5) UCLA @ (5) Illinois | 7:00 PM | Peacock |
| (8) Arizona @ Kansas State | 7:00 PM | ESPN+ |
| DePaul @ (3) Marquette | 7:30 PM | Peacock |
| (2) Alabama @ (11) Texas | 8:00 PM | |
| Colorado @ (2) Kansas | 8:00 PM | |
| (4) Connecticut @ (NFO) Creighton | 8:00 PM | CBSSN |
| (10) Georgia @ (4) Texas A&M | 8:00 PM | SEC Network |
| (FFO) Indiana @ (5) Michigan State | 8:00 PM | Peacock |
| (6) Pittsburgh @ (FFO) SMU | 8:00 PM | ACC Network |
| (11) Penn State @ USC | 8:00 PM | BTN |
| (NFO) Northwestern @ (3) Oregon | 10:00 PM | BTN |
| Santa Clara @ (9) Saint Mary's College | 10:00 PM | ESPN2 |
| (9) San Diego State @ San Jose State | 10:00 PM | |
| Colorado State @ (11) Utah State | 10:00 PM | |
| Pepperdine @ (2) Gonzaga | 0:00 | |
| (10) Arkansas @ (4) Texas A&M | 11:00 AM | |
| Miami (FL) @ (6) Pittsburgh | 11:00 AM | |
| (7) Clemson @ Florida State | 11:00 AM | |
| Vanderbilt @ (1) Tennessee | 12:00 PM | SEC Network |
| (7) Wisconsin @ (4) Purdue | 12:00 PM | CBS |
| (3) Houston @ (8) Arizona | 1:00 PM | |
| (9) West Virginia @ (4) Baylor | 1:00 PM | |
| Washington @ (11) Penn State | 1:00 PM | BTN |
| (4) Connecticut @ Seton Hall | 1:30 PM | FOX |
| Duquesne @ (7) Dayton | 1:30 PM | |
| (10) Texas Tech @ Oklahoma State | 2:00 PM | ESPN+ |
| (NFO) Missouri @ (10) Georgia | 2:30 PM | SEC Network |
| (1) Auburn @ (2) Alabama | 3:00 PM | |
| Stanford @ (1) Duke | 3:00 PM | ABC |
| (9) Cincinnati @ (1) Iowa State | 3:00 PM | |
| (6) Mississippi State @ (8) Ole Miss | 5:00 PM | |
| LSU @ (8) Oklahoma | 5:00 PM | SEC Network |
| (8) North Carolina @ Syracuse | 5:00 PM | ESPN |
| Wake Forest @ (FFO) SMU | 5:00 PM | ACC Network |
| (12) McNeese @ New Orleans | 5:00 PM | |
| (2) Kentucky @ (11) Texas | 7:00 PM | ESPN |
| (5) Michigan State @ (5) Illinois | 7:00 PM | FOX |
| TCU @ (11) Arizona State | 7:00 PM | ESPN+ |
| South Carolina @ (3) Florida | 7:30 PM | SEC Network |
| Kansas State @ (NFO) BYU | 8:00 PM | ESPN+ |
(12) Liberty @  UTEP | 8:00 PM | ESPN+ |
| (2) Kansas @ Utah | 9:00 PM | ESPN |
| Washington State @ (9) Saint Mary's College | 9:00 PM | |
| (FFO) Boise State @ (9) San Diego State | 9:00 PM | |
| (12) UC Irvine @ Hawaii | 10:59 PM | |
| Villanova @ (4) Connecticut | 5:30 PM | FS1 |
| (8) Oklahoma @ (3) Florida | 6:00 PM | ESPN2 |
| (4) Texas A&M @ (6) Mississippi State | 6:00 PM | SEC Network |
| (4) Purdue @ (5) Michigan State | 6:00 PM | Peacock |
| Syracuse @ (6) Pittsburgh | 6:00 PM | ACC Network |
| Colorado @ (1) Iowa State | 7:00 PM | ESPN+ |
| (10) Texas Tech @ TCU | 7:00 PM | ESPN+ |
| (5) Illinois @ (7) Wisconsin | 7:30 PM | FS1 |
| (2) Kansas @ (NFO) BYU | 8:00 PM | |
| Seton Hall @ (3) Marquette | 8:00 PM | CBSSN |
| (3) Houston @ (11) Arizona State | 8:00 PM | |
| Minnesota @ (5) UCLA | 9:30 PM | FS1 |
| Fresno State @ (9) San Diego State | 10:00 PM | |
| Portland @ (9) Saint Mary's College | 0:00 | |
| (11) Nebraska @ (11) Penn State | 5:30 PM | BTN |
| Vanderbilt @ (2) Kentucky | 6:00 PM | SEC Network |
| North Carolina State @ (8) North Carolina | 6:00 PM | |
| (9) Cincinnati @ (9) West Virginia | 6:00 PM | ESPN2 |
| (FFO) SMU @ Notre Dame | 6:00 PM | ACC Network |
 UIC @ (12) Drake | 6:30 PM | |
| (3) Oregon @ (11) Iowa | 7:30 PM | BTN |
| (10) Arkansas @ (1) Auburn | 8:00 PM | |
| (2) Alabama @ (NFO) Missouri | 8:00 PM | SEC Network |
| (2) Gonzaga @ Washington State | 8:00 PM | ESPN2 |
| (6) Saint John's @ DePaul | 8:00 PM | FS1 |
| San Jose State @ (11) Utah State | 8:00 PM | |
| New Mexico @ (FFO) Boise State | 9:00 PM | |
| (9) Saint Mary's College @ (2) Gonzaga | 0:00 | |
| (NFO) BYU @ (8) Arizona | 0:00 | |
| (1) Tennessee @ (4) Texas A&M | 11:00 AM | |
| (3) Oregon @ (7) Wisconsin | 11:00 AM | FOX |
| TCU @ (9) Cincinnati | 11:00 AM | |
| Florida State @ (FFO) Louisville | 11:00 AM | |
| (6) Mississippi State @ (8) Oklahoma | 12:00 PM | SEC Network |
| (9) West Virginia @ (10) Texas Tech | 12:00 PM | ESPN+ |
| (1) Iowa State @ (3) Houston | 1:00 PM | |
| (11) Penn State @ Minnesota | 1:00 PM | BTN |
| FIU @ (12) Liberty | 1:00 PM | ESPN+ |
| (6) Pittsburgh @ Notre Dame | 1:15 PM | |
| (8) Ole Miss @ Vanderbilt | 2:30 PM | SEC Network |
| (10) Georgia @ (1) Auburn | 3:00 PM | |
| Oklahoma State @ (2) Kansas | 3:00 PM | CBS |
| (4) Baylor @ Colorado | 3:00 PM | ESPN+ |
| (7) Clemson @ (FFO) SMU | 3:00 PM | ACC Network |
| Virginia @ (8) North Carolina | 3:00 PM | ESPN |
| Washington @ (11) Iowa | 3:00 PM | FS1 |
| Texas A&M-Corpus Christi @ (12) McNeese | 4:00 PM | |
| (2) Kentucky @ (2) Alabama | 5:00 PM | ESPN |
| (3) Florida @ LSU | 5:00 PM | SEC Network |
| (FFO) Boise State @ Nevada | 5:00 PM | |
| (1) Duke v. (5) Illinois | 7:00 PM | FOX |
| (9) San Diego State @ (11) Utah State | 7:00 PM | |
| (NFO) Missouri @ (10) Arkansas | 7:00 PM | |
| (11) Texas @ South Carolina | 7:30 PM | SEC Network |
(12) UC Irvine @  Cal State Bakersfield | 8:30 PM | |
| (1) Duke @ Miami (FL) | 6:00 PM | ESPN |
| Providence @ (3) Marquette | 6:00 PM | FS1 |
| (3) Florida @ (10) Georgia | 6:00 PM | SEC Network |
| (4) Baylor @ (9) Cincinnati | 6:00 PM | ESPN2 |
| Georgia Tech @ (6) Pittsburgh | 6:00 PM | ACC Network |
| (NFO) Northwestern @ Minnesota | 6:00 PM | Peacock |
| (1) Iowa State @ Oklahoma State | 7:00 PM | ESPN+ |
| (1) Tennessee @ LSU | 8:00 PM | SEC Network |
| (6) Mississippi State @ (2) Alabama | 8:00 PM | |
| (11) Iowa @ (5) Illinois | 8:00 PM | FS1 |
| Washington @ (7) Wisconsin | 8:00 PM | Peacock |
| TCU @ (9) West Virginia | 8:00 PM | CBSSN |
| (FFO) Louisville @ Virginia Tech | 8:00 PM | ACC Network |
| South Carolina @ (NFO) Missouri | 8:00 PM | |
| New Mexico @ (9) San Diego State | 10:00 PM | |
(7) Dayton @  Rhode Island | 0:00 | |
| Georgetown @ (4) Connecticut | 5:30 PM | FS1 |
| (5) Michigan State @ (6) Maryland | 5:30 PM | BTN |
| (8) Ole Miss @ (1) Auburn | 6:00 PM | |
| Vanderbilt @ (4) Texas A&M | 6:00 PM | SEC Network |
| Notre Dame @ (7) Clemson | 6:00 PM | ACC Network |
 Rice @ (5) Memphis | 7:00 PM | |
| (12) Drake @ Evansville | 7:00 PM | |
| (11) Penn State @ (FFO) Indiana | 7:30 PM | BTN |
| (2) Kentucky @ (8) Oklahoma | 8:00 PM | SEC Network |
| (6) Saint John's @ Butler | 8:00 PM | CBSSN |
| Utah @ (8) Arizona | 8:00 PM | ESPN+ |
| (11) Texas @ (10) Arkansas | 8:00 PM | |
| DePaul @ (NFO) Creighton | 8:00 PM | Peacock |
| (NFO) BYU @ (11) Arizona State | 8:30 PM | ESPN+ |
| (10) Ohio State @ USC | 9:30 PM | BTN |
| (11) Utah State @ (FFO) Boise State | 9:30 PM | |
| (FFO) SMU @ California | 10:00 PM | |
| (1) Auburn @ (2) Kentucky | 0:00 | |
| (12) McNeese @ Lamar | 0:00 | |
| (4) Connecticut @ Providence | 11:00 AM | CBS |
| (6) Maryland @ (11) Penn State | 11:00 AM | BTN |
| (7) Clemson @ Virginia | 11:00 AM | |
| Miami (FL) @ (8) North Carolina | 11:00 AM | |
| (2) Alabama @ (1) Tennessee | 12:00 PM | |
| (10) Arkansas @ South Carolina | 12:00 PM | SEC Network |
| (10) Texas Tech @ (2) Kansas | 1:00 PM | |
 Richmond @ (7) Dayton | 1:00 PM | |
| (8) Oklahoma @ (8) Ole Miss | 1:00 PM | |
| Minnesota @ (11) Nebraska | 1:00 PM | BTN |
| Seton Hall @ (6) Saint John's | 1:15 PM | CBS |
| LSU @ (6) Mississippi State | 2:30 PM | SEC Network |
| USC @ (3) Oregon | 3:00 PM | BTN |
| (11) Utah State @ Colorado State | 3:00 PM | |
| (9) Cincinnati @ (3) Houston | 3:30 PM | CBS |
| (NFO) Creighton @ Xavier | 3:30 PM | FOX |
| (FFO) SMU @ Stanford | 4:00 PM | ACC Network |
| (6) Pittsburgh @ (FFO) Louisville | 5:00 PM | ESPN2 |
| (FFO) Indiana @ Washington | 5:00 PM | Peacock |
| (NFO) Missouri @ Vanderbilt | 5:00 PM | SEC Network |
| Florida State @ (1) Duke | 6:00 PM | ACC Network |
| (11) Arizona State @ Utah | 6:00 PM | ESPN+ |
| (FFO) Boise State @ Fresno State | 6:00 PM | |
| (3) Marquette @ Georgetown | 7:00 PM | Peacock |
| Oklahoma State @ (4) Baylor | 7:00 PM | ESPN+ |
| (9) San Diego State @ Wyoming | 7:00 PM | |
| (10) Georgia @ (11) Texas | 7:00 PM | ESPN2 |
| (4) Texas A&M @ (3) Florida | 7:30 PM | SEC Network |
| (8) Arizona @ (1) Iowa State | 8:00 PM | ESPN |
| Oregon State @ (9) Saint Mary's College | 9:00 PM | |
| (9) West Virginia @ (NFO) BYU | 9:00 PM | |
 Long Beach State @ (12) UC Irvine | 9:00 PM | |
(2) Gonzaga @  San Francisco | 10:00 PM | ESPN |
| (1) Auburn @ (4) Texas A&M | 0:00 | |
| LSU @ (2) Kentucky | 0:00 | |
 Saint Louis @ (7) Dayton | 0:00 | |
| (10) Georgia @ South Carolina | 5:00 PM | SEC Network |
| Rutgers @ (4) Purdue | 6:00 PM | Peacock |
(5) Memphis @  UTSA | 6:00 PM | |
| (8) North Carolina @ Virginia Tech | 6:00 PM | |
| (NFO) Creighton @ Seton Hall | 6:00 PM | FS1 |
| (4) Baylor @ TCU | 7:00 PM | ESPN+ |
| (11) Texas @ (6) Mississippi State | 7:00 PM | SEC Network |
| (NFO) BYU @ (1) Iowa State | 8:00 PM | |
| (FFO) Indiana @ (3) Oregon | 8:00 PM | FS1 |
| (9) West Virginia @ Utah | 8:00 PM | ESPN+ |
| (11) Nebraska @ (10) Ohio State | 8:00 PM | Peacock |
| (FFO) Boise State @ Air Force | 8:00 PM | |
| Syracuse @ (FFO) SMU | 8:00 PM | |
| (10) Arkansas @ Vanderbilt | 9:00 PM | SEC Network |
| (11) Arizona State @ (8) Arizona | 10:00 PM | |
| (9) San Diego State @ UNLV | 10:00 PM | |
| (6) Maryland @ (7) Michigan | 5:30 PM | BTN |
| (3) Florida @ (2) Alabama | 6:00 PM | |
| (6) Pittsburgh @ North Carolina State | 6:00 PM | ACC Network |
| (7) Clemson @ Boston College | 6:00 PM | |
| Kansas State @ (9) Cincinnati | 6:00 PM | ESPN+ |
| (NFO) Missouri @ (8) Oklahoma | 7:00 PM | SECN+ |
| Colorado @ (10) Texas Tech | 7:00 PM | ESPN+ |
| (3) Marquette @ (4) Connecticut | 7:30 PM | FS1 |
| (7) Wisconsin @ Minnesota | 7:30 PM | BTN |
| (1) Tennessee @ (8) Ole Miss | 8:00 PM | |
| California @ (FFO) Louisville | 8:00 PM | ACC Network |
| (6) Saint John's @ (3) Marquette | 0:00 | |
| Seton Hall @ (4) Connecticut | 0:00 | |
| USC @ (5) UCLA | 0:00 | FOX |
| Butler @ (NFO) Creighton | 0:00 | |
| (2) Kentucky @ (NFO) Missouri | 11:00 AM | |
| (6) Mississippi State @ (10) Arkansas | 11:00 AM | |
| Vanderbilt @ (10) Georgia | 11:00 AM | ESPNU |
| (11) Penn State @ (7) Wisconsin | 12:00 PM | Peacock |
| (1) Iowa State @ Kansas State | 12:30 PM | CBS |
| (2) Alabama @ (1) Auburn | 1:00 PM | ESPN |
| South Carolina @ (1) Tennessee | 1:00 PM | SEC Network |
| Stanford @ (FFO) Louisville | 1:00 PM | ESPNU |
| (NFO) Northwestern @ (6) Maryland | 2:00 PM | Peacock |
| (9) Cincinnati @ Oklahoma State | 2:00 PM | ESPN+ |
| (12) Liberty @ Western Kentucky | 2:00 PM | ESPN+ |
| (10) Ohio State @ (FFO) Indiana | 2:45 PM | CBS |
| (8) Arizona @ (2) Kansas | 3:00 PM | ESPN |
| (4) Texas A&M @ LSU | 3:00 PM | SEC Network |
| Air Force @ (11) Utah State | 3:00 PM | |
| (FFO) SMU @ Florida State | 3:00 PM | ESPNU |
| UCF @ (9) West Virginia | 4:00 PM | ESPN+ |
| (8) Ole Miss @ (3) Florida | 5:00 PM | SEC Network |
| Boston College @ (6) Pittsburgh | 5:00 PM | ACC Network |
| Virginia Tech @ (7) Clemson | 5:00 PM | ESPNU |
| (1) Duke @ (8) North Carolina | 5:30 PM | ESPN |
| (8) Oklahoma @ (11) Texas | 7:00 PM | SEC Network |
| (3) Houston @ (4) Baylor | 8:00 PM | ESPN2 |
(12) UC Irvine @  UC Santa Barbara | 9:00 PM | |
| Nevada @ (9) San Diego State | 9:30 PM | |
| (10) Texas Tech @ (11) Arizona State | 9:30 PM | |
| Utah @ (NFO) BYU | 9:30 PM | |
Buffalo @ (10) 
Merrimack @ (9) 
Houston Christian @ (4) 
Florida A&M @ (NFO) 
La Salle @ (7) 
Norfolk State @ (1) 
North Texas @ (5) 
Bradley
Cal State Northridge
Temple
Cal State Fullerton @ (12) 
Charlotte
Stephen F. Austin @ (12) 
Valparaiso @ (12) 
Wichita State @ (5) 
Saint Joseph's @ (7) 
UAB @ (5) 
Northern Iowa @ (12) 
Kennesaw State
Tulane
Incarnate Word @ (12) 
Tulsa @ (5) 
VCU @ (7) 
Fordham
South Florida