January 21
(11)  Vanderbilt @ (1)  Alabama | 6:00 PM | SEC Network |
(5)  Mississippi State @ (2)  Tennessee | 6:00 PM | ESPN2 |
(6)  Texas Tech @ (FFO)  Cincinnati | 6:00 PM | ESPNU |
 Butler @ (8)  Connecticut | 6:00 PM | FS1 |
(12)  VCU @  Rhode Island | 6:00 PM | CBSSN |
(11)  Ohio State @ (3)  Purdue | 6:30 PM | Peacock |
(NFO)  UCF @ (1)  Iowa State | 7:00 PM | ESPN+ |
(3)  Marquette @  Seton Hall | 7:00 PM | Peacock |
(5)  Arizona @  Oklahoma State | 8:00 PM | ESPNU |
 Arizona State @ (7)  West Virginia | 8:00 PM | CBSSN |
(7)  Missouri @ (11)  Texas | 8:00 PM | SEC Network |
(7)  Louisville @ (FFO)  SMU | 8:00 PM | ACC Network |
(9)  Creighton @  DePaul | 8:00 PM | FS1 |
(10)  North Carolina @  Wake Forest | 8:00 PM | ESPN |
 Minnesota @ (NFO)  Iowa | 8:00 PM | BTN |
(5)  Wisconsin @ (8)  UCLA | 8:30 PM | Peacock |
 Washington @ (4)  Oregon | 10:00 PM | BTN |
(NFO)  BYU @  Colorado | 10:00 PM | ESPNU |
January 22
 Utah @ (2)  Houston | 5:00 PM | ESPN+ |
(2)  Florida @  South Carolina | 6:00 PM | SEC Network |
(2)  Kansas @  TCU | 6:00 PM | ESPN2 |
(FFO)  Xavier @ (6)  Saint John's | 6:00 PM | FS1 |
 Syracuse @ (7)  Clemson | 6:00 PM | ACC Network |
(FFO)  Indiana @  Northwestern | 6:00 PM | BTN |
 Valparaiso @ (12)  Drake | 6:30 PM | |
(4)  Texas A&M @ (4)  Ole Miss | 8:00 PM | |
 Kansas State @ (8)  Baylor | 8:00 PM | |
 Nevada @ (8)  Utah State | 8:00 PM | |
(9)  Georgia @  Arkansas | 8:00 PM | SEC Network |
 USC @ (11)  Nebraska | 8:00 PM | BTN |
(10)  San Diego State @  Air Force | 9:30 PM |
January 23
 Wichita State @ (6)  Memphis | 6:00 PM | ESPN2 |
 Appalachian State @ (12)  Arkansas State | 7:00 PM | |
(9)  Maryland @ (3)  Illinois | 8:00 PM | FS1 |
 San Francisco @ (9)  Saint Mary's College | 8:00 PM | |
(11)  UC Irvine @  UC Riverside | 9:00 PM |
January 24
 Villanova @ (3) Marquette | 6:00 PM | FS1 |
(5)  Michigan @ (3) Purdue | 7:00 PM | FOX |
(NFO)  Penn State @ (NFO) Iowa | 8:00 PM | FS1 |
 Saint Bonaventure @ (12) VCU | 8:00 PM | ESPNU |
| (8) UCLA @ Washington | 10:00 PM | FS1 |
January 25
(6)  Gonzaga @  Portland | 0:00 | |
(10)  Pittsburgh @ Syracuse | 11:00 AM | |
(FFO) SMU @  North Carolina State | 11:00 AM | |
| (5) Mississippi State @ South Carolina | 12:00 PM | SEC Network |
(3)  Michigan State @  Rutgers | 12:30 PM | CBS |
| Seton Hall @ (9) Creighton | 12:30 PM | FS1 |
| (1) Iowa State @ Arizona State | 1:00 PM | ESPN+ |
 Boston College @ (10) North Carolina | 1:15 PM | |
(4)  Kentucky @ (11) Vanderbilt | 1:30 PM | |
| (4) Texas A&M @ (11) Texas | 1:30 PM | |
| Colorado @ (5) Arizona | 2:00 PM | ESPN+ |
(11)  New Mexico @  UNLV | 2:00 PM | |
 Texas State @ (12) Arkansas State | 2:00 PM | |
| (9) Georgia @ (2) Florida | 2:30 PM | SEC Network |
| (4) Oregon @ Minnesota | 3:00 PM | BTN |
| (8) Utah State @ Air Force | 3:00 PM | |
| TCU @ (NFO) UCF | 3:00 PM | ESPN+ |
(12) Drake @  Missouri State | 3:00 PM | |
(1)  Duke @ Wake Forest | 3:30 PM | ESPN |
| (8) Baylor @ Utah | 3:30 PM | |
(7) Clemson @  Virginia Tech | 4:00 PM | ACC Network |
(12)  McNeese @  UTRGV | 4:30 PM | |
| (4) Ole Miss @ (7) Missouri | 5:00 PM | SEC Network |
| (7) West Virginia @ Kansas State | 5:00 PM | CBSSN |
| (2) Houston @ (2) Kansas | 5:30 PM | |
| (8) Connecticut @ (FFO) Xavier | 7:00 PM | FOX |
(9) Saint Mary's College @  Washington State | 7:00 PM | |
(2) Tennessee @ (1)  Auburn | 7:30 PM | |
 LSU @ (1) Alabama | 7:30 PM | SEC Network |
(10)  Oklahoma @ Arkansas | 7:30 PM | |
| (10) San Diego State @ Nevada | 9:00 PM | |
 Hawaii @ (11) UC Irvine | 9:00 PM | |
| (FFO) Cincinnati @ (NFO) BYU | 9:00 PM | ESPN2 |
January 26
| (9) Maryland @ (FFO) Indiana | 11:00 AM | CBS |
| (11) Nebraska @ (5) Wisconsin | 12:00 PM | BTN |
 UAB @ (6) Memphis | 12:00 PM | |
| Northwestern @ (3) Illinois | 2:00 PM | BTN |
| Oklahoma State @ (6) Texas Tech | 2:00 PM | ESPN+ |
January 27
| (NFO) Penn State @ (5) Michigan | 5:30 PM | BTN |
| (NFO) Iowa @ (11) Ohio State | 7:00 PM | FS1 |
(12) McNeese @  Texas A&M-Corpus Christi | 7:00 PM | |
| North Carolina State @ (1) Duke | 7:30 PM | ESPN |
| (8) UCLA @ USC | 9:00 PM | FS1 |
| (1) Iowa State @ (5) Arizona | 9:30 PM | ESPN |
January 28
(6) Saint John's @  Georgetown | 5:30 PM | FS1 |
| (4) Kentucky @ (2) Tennessee | 6:00 PM | ESPN |
| Wake Forest @ (7) Louisville | 6:00 PM | ACC Network |
| South Carolina @ (9) Georgia | 6:00 PM | SEC Network |
| (NFO) UCF @ (2) Kansas | 7:00 PM | ESPN+ |
| Minnesota @ (3) Michigan State | 7:00 PM | Peacock |
(12) VCU @  Saint Louis | 7:00 PM | |
| (3) Marquette @ Butler | 7:30 PM | FS1 |
| (10) Oklahoma @ (4) Texas A&M | 8:00 PM | SEC Network |
| (8) Baylor @ (NFO) BYU | 8:00 PM | |
| (10) North Carolina @ (10) Pittsburgh | 8:00 PM | ESPN |
| (FFO) Cincinnati @ Utah | 9:00 PM | CBSSN |
 Oregon State @ (6) Gonzaga | 10:00 PM | |
 San Jose State @ (10) San Diego State | 10:00 PM |
January 29
| (1) Auburn @ LSU | 6:00 PM | SEC Network |
| (2) Houston @ (7) West Virginia | 6:00 PM | ESPN+ |
| (5) Wisconsin @ (9) Maryland | 6:00 PM | BTN |
| TCU @ (6) Texas Tech | 6:00 PM | |
 Northern Iowa @ (12) Drake | 6:00 PM | |
| DePaul @ (8) Connecticut | 7:00 PM | Peacock |
| (FFO) Xavier @ (9) Creighton | 7:00 PM | FS1 |
(12) Arkansas State @  Southern Miss | 7:00 PM | |
| (1) Alabama @ (5) Mississippi State | 8:00 PM | SEC Network |
| (11) Texas @ (4) Ole Miss | 8:00 PM | ESPN2 |
(9) Saint Mary's College @  Santa Clara | 8:00 PM | ESPNU |
 California @ (FFO) SMU | 8:00 PM | ACC Network |
| UNLV @ (8) Utah State | 9:00 PM |
January 30
| (11) Ohio State @ (NFO) Penn State | 5:30 PM | FS1 |
| (3) Illinois @ (11) Nebraska | 7:30 PM | FS1 |
(6) Memphis @  Tulane | 8:00 PM | |
(11) UC Irvine @  Long Beach State | 9:00 PM | |
| (4) Oregon @ (8) UCLA | 9:30 PM | FS1 |
January 31
| (FFO) Indiana @ (3) Purdue | 7:00 PM | FOX |
February 1
| (9) Georgia @ (1) Alabama | 0:00 | |
(12) Drake @  Southern Illinois | 0:00 | |
| (2) Florida @ (2) Tennessee | 11:00 AM | |
 Providence @ (6) Saint John's | 11:00 AM | CBSSN |
| (10) Pittsburgh @ Wake Forest | 11:00 AM | |
| (7) Missouri @ (5) Mississippi State | 12:00 PM | SEC Network |
| (5) Arizona @ Arizona State | 12:00 PM | CBS |
| (9) Creighton @ Villanova | 12:00 PM | FOX |
| (7) Clemson @ North Carolina State | 12:30 PM | |
| Kansas State @ (1) Iowa State | 1:00 PM | |
| (5) Wisconsin @ Northwestern | 1:00 PM | FS1 |
| (5) Michigan @ Rutgers | 2:30 PM | FOX |
| (11) Vanderbilt @ (10) Oklahoma | 2:30 PM | SEC Network |
(7) Louisville @  Georgia Tech | 2:45 PM | |
| (1) Auburn @ (4) Ole Miss | 3:00 PM | |
| (2) Kansas @ (8) Baylor | 3:00 PM | ESPN |
| (NFO) BYU @ (NFO) UCF | 3:00 PM | ESPN+ |
 Richmond @ (12) VCU | 3:00 PM | |
(12) McNeese @  Nicholls | 3:00 PM | |
| (3) Michigan State @ USC | 3:30 PM | Peacock |
| (12) Arkansas State @ Texas State | 4:00 PM | |
| (6) Texas Tech @ (2) Houston | 5:00 PM | ESPN2 |
| (11) Texas @ LSU | 5:00 PM | SEC Network |
 Stanford @ (FFO) SMU | 5:00 PM | ACC Network |
| (10) North Carolina @ (1) Duke | 5:30 PM | ESPN |
| (8) Connecticut @ (3) Marquette | 7:00 PM | FOX |
 Wyoming @ (10) San Diego State | 7:00 PM | |
| (4) Texas A&M @ South Carolina | 7:30 PM | SEC Network |
| Arkansas @ (4) Kentucky | 8:00 PM | ESPN |
| (11) New Mexico @ (8) Utah State | 8:30 PM | |
 UC Davis @ (11) UC Irvine | 9:00 PM | |
| (6) Gonzaga @ (9) Saint Mary's College | 10:00 PM | ESPN |
February 2
| (11) Ohio State @ (3) Illinois | 12:00 PM | CBS |
| (7) West Virginia @ (FFO) Cincinnati | 1:00 PM | ESPN+ |
(6) Memphis @  Rice | 2:00 PM | |
| (11) Nebraska @ (4) Oregon | 6:30 PM | BTN |
February 3
 Virginia @ (10) Pittsburgh | 6:00 PM | ESPN |
 Incarnate Word @ (12) McNeese | 6:00 PM | |
| (1) Iowa State @ (2) Kansas | 8:00 PM | ESPN |
February 4
| (3) Marquette @ (6) Saint John's | 5:30 PM | FS1 |
| (11) Vanderbilt @ (2) Florida | 6:00 PM | SEC Network |
| (3) Purdue @ (NFO) Iowa | 6:00 PM | Peacock |
| (4) Kentucky @ (4) Ole Miss | 6:00 PM | ESPN |
| Minnesota @ (NFO) Penn State | 6:00 PM | BTN |
 La Salle @ (12) VCU | 6:00 PM | |
| Oklahoma State @ (2) Houston | 7:00 PM | ESPN+ |
(12) Drake @  Murray State | 7:00 PM | |
| (8) Utah State @ Wyoming | 7:30 PM | |
| Georgetown @ (FFO) Xavier | 7:30 PM | FS1 |
| (10) Oklahoma @ (1) Auburn | 8:00 PM | SEC Network |
| (FFO) Indiana @ (5) Wisconsin | 8:00 PM | Peacock |
| (8) Baylor @ (6) Texas Tech | 8:00 PM | ESPN2 |
| Georgia Tech @ (7) Clemson | 8:00 PM | ACC Network |
| (3) Michigan State @ (8) UCLA | 9:00 PM | Peacock |
| (5) Arizona @ (NFO) BYU | 10:00 PM |
February 5
| (4) Oregon @ (5) Michigan | 5:30 PM | BTN |
| (1) Duke @ Syracuse | 6:00 PM | ESPN2 |
| (7) Missouri @ (2) Tennessee | 6:00 PM | SEC Network |
| (7) Louisville @ Boston College | 6:00 PM | ACC Network |
| (FFO) Cincinnati @ (NFO) UCF | 6:00 PM | CBSSN |
(12) Arkansas State @  Marshall | 6:00 PM | |
 Tulsa @ (6) Memphis | 7:00 PM | |
| (7) West Virginia @ TCU | 7:00 PM | ESPN+ |
| (3) Illinois @ Rutgers | 7:30 PM | BTN |
| (9) Creighton @ Providence | 7:30 PM | FS1 |
| LSU @ (9) Georgia | 8:00 PM | SEC Network |
| Arkansas @ (11) Texas | 8:00 PM | ESPN2 |
| (FFO) SMU @ Virginia Tech | 8:00 PM | ACC Network |
 Colorado State @ (11) New Mexico | 9:30 PM | |
| (11) Nebraska @ Washington | 9:30 PM | BTN |
February 6
 Loyola-Marymount @ (6) Gonzaga | 0:00 | |
| (9) Maryland @ (11) Ohio State | 6:00 PM | FS1 |
| (9) Saint Mary's College @ San Francisco | 8:00 PM | ESPN2 |
February 7
| USC @ (3) Purdue | 6:00 PM | FS1 |
(12) VCU @  Dayton | 6:00 PM | ESPN2 |
| (6) Saint John's @ (8) Connecticut | 7:00 PM | FOX |
(8) Utah State @  Fresno State | 9:00 PM |
February 8
(6) Gonzaga @  Pacific | 0:00 | |
 Indiana State @ (12) Drake | 0:00 | |
| (2) Tennessee @ (10) Oklahoma | 11:00 AM | |
| (4) Oregon @ (3) Michigan State | 11:00 AM | FOX |
| South Carolina @ (4) Kentucky | 11:00 AM | |
| TCU @ (1) Iowa State | 12:00 PM | ESPN+ |
| (5) Michigan @ (FFO) Indiana | 12:00 PM | CBS |
| (5) Wisconsin @ (NFO) Iowa | 12:00 PM | NBC |
| (11) Texas @ (11) Vanderbilt | 12:00 PM | SEC Network |
| (2) Kansas @ Kansas State | 1:00 PM | ESPN |
| (3) Marquette @ (9) Creighton | 1:00 PM | FOX |
 Miami (FL) @ (7) Louisville | 1:00 PM | ESPN2 |
| (NFO) UCF @ (8) Baylor | 1:00 PM | ESPN+ |
| (4) Texas A&M @ (7) Missouri | 2:30 PM | SEC Network |
| (2) Florida @ (1) Auburn | 3:00 PM | |
| (2) Houston @ Colorado | 3:00 PM | ESPN+ |
| (NFO) Penn State @ (8) UCLA | 3:00 PM | BTN |
| (10) Pittsburgh @ (10) North Carolina | 3:00 PM | |
| (11) New Mexico @ Air Force | 3:00 PM | |
| Utah @ (7) West Virginia | 4:00 PM | ESPN+ |
 Northwestern State @ (12) McNeese | 4:00 PM | |
| (1) Duke @ (7) Clemson | 5:00 PM | ESPN |
| (3) Illinois @ Minnesota | 5:00 PM | BTN |
| (5) Mississippi State @ (9) Georgia | 5:00 PM | SEC Network |
| (NFO) BYU @ (FFO) Cincinnati | 5:00 PM | ESPN2 |
| (1) Alabama @ Arkansas | 7:00 PM | ESPN |
| (4) Ole Miss @ LSU | 7:30 PM | SEC Network |
| (6) Texas Tech @ (5) Arizona | 9:00 PM | ESPN |
| (9) Saint Mary's College @ Oregon State | 9:00 PM | |
| (10) San Diego State @ Colorado State | 9:00 PM | |
 UC San Diego @ (11) UC Irvine | 9:00 PM |
February 9
| Rutgers @ (9) Maryland | 11:00 AM | BTN |
| (FFO) Xavier @ Villanova | 11:00 AM | FS1 |
 Temple @ (6) Memphis | 1:00 PM | ESPN2 |
| (11) Ohio State @ (11) Nebraska | 1:00 PM | BTN |
February 10
| (10) North Carolina @ (7) Clemson | 6:00 PM | ESPN |
 East Texas A&M @ (12) McNeese | 6:00 PM | |
| (8) Baylor @ (2) Houston | 8:00 PM | ESPN |
February 11
| (1) Auburn @ (11) Vanderbilt | 6:00 PM | SEC Network |
| (1) Iowa State @ (NFO) UCF | 6:00 PM | ESPN+ |
| (2) Tennessee @ (4) Kentucky | 6:00 PM | ESPN |
| (2) Florida @ (5) Mississippi State | 6:00 PM | |
| (3) Purdue @ (5) Michigan | 6:00 PM | Peacock |
| (NFO) BYU @ (7) West Virginia | 6:00 PM | CBSSN |
| Utah @ (FFO) Cincinnati | 6:00 PM | ESPN+ |
| (8) UCLA @ (3) Illinois | 7:00 PM | Peacock |
| (5) Arizona @ Kansas State | 7:00 PM | ESPN+ |
| DePaul @ (3) Marquette | 7:30 PM | Peacock |
| (1) Alabama @ (11) Texas | 8:00 PM | |
| Colorado @ (2) Kansas | 8:00 PM | |
| (FFO) Indiana @ (3) Michigan State | 8:00 PM | Peacock |
| (9) Georgia @ (4) Texas A&M | 8:00 PM | SEC Network |
| (8) Connecticut @ (9) Creighton | 8:00 PM | CBSSN |
| (10) Pittsburgh @ (FFO) SMU | 8:00 PM | ACC Network |
| (NFO) Penn State @ USC | 8:00 PM | BTN |
| Northwestern @ (4) Oregon | 10:00 PM | BTN |
| Colorado State @ (8) Utah State | 10:00 PM | |
| Santa Clara @ (9) Saint Mary's College | 10:00 PM | ESPN2 |
| (10) San Diego State @ San Jose State | 10:00 PM |
February 12
| (6) Saint John's @ Villanova | 5:00 PM | FS1 |
| (NFO) Iowa @ Rutgers | 5:30 PM | BTN |
| (4) Ole Miss @ South Carolina | 6:00 PM | SEC Network |
| (7) Louisville @ North Carolina State | 6:00 PM | |
(12) VCU @  George Washington | 6:00 PM | |
| (FFO) Xavier @ Providence | 7:00 PM | Peacock |
| Washington @ (11) Ohio State | 7:30 PM | BTN |
| Southern Miss @ (12) Arkansas State | 7:30 PM | |
| California @ (1) Duke | 8:00 PM | ACC Network |
| Arizona State @ (6) Texas Tech | 8:00 PM | CBSSN |
| (10) Oklahoma @ (7) Missouri | 8:00 PM | SEC Network |
(12) Drake @  Illinois State | 8:00 PM | |
| Wyoming @ (11) New Mexico | 9:00 PM |
February 13
| (9) Maryland @ (11) Nebraska | 7:30 PM | BTN |
(6) Memphis @  South Florida | 8:00 PM | ESPN2 |
 UC Santa Barbara @ (11) UC Irvine | 9:00 PM | |
| San Francisco @ (6) Gonzaga | 10:00 PM | ESPN |
February 14
| (8) UCLA @ (FFO) Indiana | 7:00 PM | FOX |
February 15
 Pepperdine @ (6) Gonzaga | 0:00 | |
| Arkansas @ (4) Texas A&M | 11:00 AM | |
(7) Clemson @  Florida State | 11:00 AM | |
| Miami (FL) @ (10) Pittsburgh | 11:00 AM | |
| DePaul @ (FFO) Xavier | 11:00 AM | FS1 |
| (11) Vanderbilt @ (2) Tennessee | 12:00 PM | SEC Network |
| (5) Wisconsin @ (3) Purdue | 12:00 PM | CBS |
| (2) Houston @ (5) Arizona | 1:00 PM | |
| (7) West Virginia @ (8) Baylor | 1:00 PM | |
| Washington @ (NFO) Penn State | 1:00 PM | BTN |
| (8) Connecticut @ Seton Hall | 1:30 PM | FOX |
| (6) Texas Tech @ Oklahoma State | 2:00 PM | ESPN+ |
| (NFO) UCF @ Colorado | 2:00 PM | ESPN+ |
| (7) Missouri @ (9) Georgia | 2:30 PM | SEC Network |
 Troy @ (12) Arkansas State | 2:30 PM | |
| (1) Auburn @ (1) Alabama | 3:00 PM | |
| Stanford @ (1) Duke | 3:00 PM | ABC |
| (FFO) Cincinnati @ (1) Iowa State | 3:00 PM | |
| (5) Mississippi State @ (4) Ole Miss | 5:00 PM | |
| (10) North Carolina @ Syracuse | 5:00 PM | ESPN |
| LSU @ (10) Oklahoma | 5:00 PM | SEC Network |
| Wake Forest @ (FFO) SMU | 5:00 PM | ACC Network |
(12) McNeese @  New Orleans | 5:00 PM | |
| (3) Michigan State @ (3) Illinois | 7:00 PM | FOX |
| (4) Kentucky @ (11) Texas | 7:00 PM | ESPN |
| South Carolina @ (2) Florida | 7:30 PM | SEC Network |
| Kansas State @ (NFO) BYU | 8:00 PM | ESPN+ |
| (2) Kansas @ Utah | 9:00 PM | ESPN |
| Washington State @ (9) Saint Mary's College | 9:00 PM | |
 Boise State @ (10) San Diego State | 9:00 PM | |
| (11) UC Irvine @ Hawaii | 10:59 PM |
February 16
 Bradley @ (12) Drake | 0:00 | |
| (6) Memphis @ Wichita State | 11:00 AM | |
| (5) Michigan @ (11) Ohio State | 12:00 PM | CBS |
| (9) Creighton @ (6) Saint John's | 2:00 PM | FS1 |
| (11) Nebraska @ Northwestern | 2:00 PM | BTN |
| (8) Utah State @ (11) New Mexico | 3:00 PM | |
| (NFO) Iowa @ (9) Maryland | 4:00 PM | FS1 |
| Rutgers @ (4) Oregon | 6:00 PM | FS1 |
(7) Louisville @  Notre Dame | 7:00 PM | ACC Network |
February 17
(12) McNeese @  Southeastern Louisiana | 5:00 PM | |
| (1) Duke @ Virginia | 7:00 PM | ESPN |
| (5) Arizona @ (8) Baylor | 9:00 PM | ESPN |
February 18
| Villanova @ (8) Connecticut | 5:30 PM | FS1 |
| (10) Oklahoma @ (2) Florida | 6:00 PM | ESPN2 |
| (3) Purdue @ (3) Michigan State | 6:00 PM | Peacock |
| (4) Texas A&M @ (5) Mississippi State | 6:00 PM | SEC Network |
| Syracuse @ (10) Pittsburgh | 6:00 PM | ACC Network |
| Colorado @ (1) Iowa State | 7:00 PM | ESPN+ |
| (6) Texas Tech @ TCU | 7:00 PM | ESPN+ |
| Butler @ (FFO) Xavier | 7:00 PM | Peacock |
| (3) Illinois @ (5) Wisconsin | 7:30 PM | FS1 |
| (2) Houston @ Arizona State | 8:00 PM | |
| (2) Kansas @ (NFO) BYU | 8:00 PM | |
| Seton Hall @ (3) Marquette | 8:00 PM | CBSSN |
| Minnesota @ (8) UCLA | 9:30 PM | FS1 |
| Fresno State @ (10) San Diego State | 10:00 PM |
February 19
| Portland @ (9) Saint Mary's College | 0:00 | |
 UMass @ (12) VCU | 5:00 PM | |
| (11) Nebraska @ (NFO) Penn State | 5:30 PM | BTN |
| (11) Vanderbilt @ (4) Kentucky | 6:00 PM | SEC Network |
| (FFO) Cincinnati @ (7) West Virginia | 6:00 PM | ESPN2 |
| North Carolina State @ (10) North Carolina | 6:00 PM | |
| (FFO) SMU @ Notre Dame | 6:00 PM | ACC Network |
 UIC @ (12) Drake | 6:30 PM | |
 South Alabama @ (12) Arkansas State | 7:00 PM | |
| (4) Oregon @ (NFO) Iowa | 7:30 PM | BTN |
| Arkansas @ (1) Auburn | 8:00 PM | |
| (1) Alabama @ (7) Missouri | 8:00 PM | SEC Network |
| (6) Gonzaga @ Washington State | 8:00 PM | ESPN2 |
| (6) Saint John's @ DePaul | 8:00 PM | FS1 |
| San Jose State @ (8) Utah State | 8:00 PM | |
| (NFO) UCF @ Oklahoma State | 8:00 PM | |
| (11) New Mexico @ Boise State | 9:00 PM |
February 20
| Northwestern @ (11) Ohio State | 5:30 PM | FS1 |
| USC @ (9) Maryland | 7:30 PM | FS1 |
 Cal State Northridge @ (11) UC Irvine | 9:00 PM |
February 21
| (3) Marquette @ Villanova | 6:00 PM | FS1 |
| (3) Michigan State @ (5) Michigan | 7:00 PM | FOX |
February 22
| (NFO) BYU @ (5) Arizona | 0:00 | |
| (9) Saint Mary's College @ (6) Gonzaga | 0:00 | |
| (2) Tennessee @ (4) Texas A&M | 11:00 AM | |
| (4) Oregon @ (5) Wisconsin | 11:00 AM | FOX |
| Florida State @ (7) Louisville | 11:00 AM | |
| TCU @ (FFO) Cincinnati | 11:00 AM | |
| (5) Mississippi State @ (10) Oklahoma | 12:00 PM | SEC Network |
| (7) West Virginia @ (6) Texas Tech | 12:00 PM | ESPN+ |
| (1) Iowa State @ (2) Houston | 1:00 PM | |
| (NFO) Penn State @ Minnesota | 1:00 PM | BTN |
| (10) Pittsburgh @ Notre Dame | 1:15 PM | |
 ULM @ (12) Arkansas State | 2:00 PM | |
| (4) Ole Miss @ (11) Vanderbilt | 2:30 PM | SEC Network |
| (9) Georgia @ (1) Auburn | 3:00 PM | |
| Oklahoma State @ (2) Kansas | 3:00 PM | CBS |
| (7) Clemson @ (FFO) SMU | 3:00 PM | ACC Network |
| (8) Baylor @ Colorado | 3:00 PM | ESPN+ |
| Virginia @ (10) North Carolina | 3:00 PM | ESPN |
| Washington @ (NFO) Iowa | 3:00 PM | FS1 |
 George Mason @ (12) VCU | 3:00 PM | |
| Texas A&M-Corpus Christi @ (12) McNeese | 4:00 PM | |
| (4) Kentucky @ (1) Alabama | 5:00 PM | ESPN |
| (2) Florida @ LSU | 5:00 PM | SEC Network |
| (1) Duke v. (3) Illinois | 7:00 PM | FOX |
| (7) Missouri @ Arkansas | 7:00 PM | |
| (10) San Diego State @ (8) Utah State | 7:00 PM | |
| (11) Texas @ South Carolina | 7:30 PM | SEC Network |
(11) UC Irvine @  Cal State Bakersfield | 8:30 PM |
February 23
| (8) Connecticut @ (6) Saint John's | 11:00 AM | FOX |
| (3) Purdue @ (FFO) Indiana | 12:30 PM | CBS |
 FAU @ (6) Memphis | 1:00 PM | |
| (FFO) Xavier @ Seton Hall | 1:00 PM | FS1 |
| (11) Ohio State @ (8) UCLA | 2:45 PM | CBS |
| Georgetown @ (9) Creighton | 3:00 PM | Peacock |
| Utah @ (NFO) UCF | 3:00 PM | ESPN+ |
| (12) Drake @ Northern Iowa | 3:00 PM | ESPN2 |
February 24
| (10) North Carolina @ Florida State | 6:00 PM | ESPN |
| UTRGV @ (12) McNeese | 6:00 PM | |
| (5) Michigan @ (11) Nebraska | 7:00 PM | FS1 |
| (2) Houston @ (6) Texas Tech | 8:00 PM | ESPN |
| (2) Kansas @ Colorado | 10:00 PM | ESPN |
February 25
| (1) Duke @ Miami (FL) | 6:00 PM | ESPN |
| (2) Florida @ (9) Georgia | 6:00 PM | SEC Network |
| Providence @ (3) Marquette | 6:00 PM | FS1 |
| (8) Baylor @ (FFO) Cincinnati | 6:00 PM | ESPN2 |
| Georgia Tech @ (10) Pittsburgh | 6:00 PM | ACC Network |
| (12) VCU @ Richmond | 6:00 PM | |
| (1) Iowa State @ Oklahoma State | 7:00 PM | ESPN+ |
| (5) Mississippi State @ (1) Alabama | 8:00 PM | |
| (2) Tennessee @ LSU | 8:00 PM | SEC Network |
| (NFO) Iowa @ (3) Illinois | 8:00 PM | FS1 |
| Washington @ (5) Wisconsin | 8:00 PM | Peacock |
| TCU @ (7) West Virginia | 8:00 PM | CBSSN |
| South Carolina @ (7) Missouri | 8:00 PM | |
| (7) Louisville @ Virginia Tech | 8:00 PM | ACC Network |
| (11) New Mexico @ (10) San Diego State | 10:00 PM |
February 26
| (3) Michigan State @ (9) Maryland | 5:30 PM | BTN |
| Georgetown @ (8) Connecticut | 5:30 PM | FS1 |
| (4) Ole Miss @ (1) Auburn | 6:00 PM | |
| (11) Vanderbilt @ (4) Texas A&M | 6:00 PM | SEC Network |
| Notre Dame @ (7) Clemson | 6:00 PM | ACC Network |
| Kansas State @ (NFO) UCF | 6:00 PM | ESPN+ |
| Rice @ (6) Memphis | 7:00 PM | |
(12) Drake @  Evansville | 7:00 PM | |
| (NFO) Penn State @ (FFO) Indiana | 7:30 PM | BTN |
(12) Arkansas State @  Louisiana | 7:30 PM | |
| (4) Kentucky @ (10) Oklahoma | 8:00 PM | SEC Network |
| Utah @ (5) Arizona | 8:00 PM | ESPN+ |
| (6) Saint John's @ Butler | 8:00 PM | CBSSN |
| DePaul @ (9) Creighton | 8:00 PM | Peacock |
| (11) Texas @ Arkansas | 8:00 PM | |
| (NFO) BYU @ Arizona State | 8:30 PM | ESPN+ |
| (8) Utah State @ Boise State | 9:30 PM | |
| (11) Ohio State @ USC | 9:30 PM | BTN |
| (FFO) SMU @ California | 10:00 PM |
February 27
| (9) Saint Mary's College @ Loyola-Marymount | 0:00 | |
| Rutgers @ (5) Michigan | 8:00 PM | Peacock |
(11) UC Irvine @  Cal State Fullerton | 9:00 PM | |
| (6) Gonzaga @ Santa Clara | 10:00 PM |
February 28
 Davidson @ (12) VCU | 6:00 PM | ESPN2 |
| (12) Arkansas State @ ULM | 6:30 PM | |
| (8) UCLA @ (3) Purdue | 7:00 PM | FOX |
| (NFO) Iowa @ Northwestern | 8:00 PM | FS1 |
March 1
| (1) Auburn @ (4) Kentucky | 0:00 | |
(12) McNeese @  Lamar | 0:00 | |
| (7) Clemson @ Virginia | 11:00 AM | |
| (8) Connecticut @ Providence | 11:00 AM | CBS |
| (9) Maryland @ (NFO) Penn State | 11:00 AM | BTN |
| Miami (FL) @ (10) North Carolina | 11:00 AM | |
| (1) Alabama @ (2) Tennessee | 12:00 PM | |
| (6) Texas Tech @ (2) Kansas | 1:00 PM | |
| (10) Oklahoma @ (4) Ole Miss | 1:00 PM | |
| Minnesota @ (11) Nebraska | 1:00 PM | BTN |
| Seton Hall @ (6) Saint John's | 1:15 PM | CBS |
| LSU @ (5) Mississippi State | 2:30 PM | SEC Network |
| USC @ (4) Oregon | 3:00 PM | BTN |
| (8) Utah State @ Colorado State | 3:00 PM | |
| Air Force @ (11) New Mexico | 3:00 PM | |
| (NFO) UCF @ TCU | 3:00 PM | ESPN+ |
| (FFO) Cincinnati @ (2) Houston | 3:30 PM | CBS |
| (9) Creighton @ (FFO) Xavier | 3:30 PM | FOX |
| (FFO) SMU @ Stanford | 4:00 PM | ACC Network |
| (7) Missouri @ (11) Vanderbilt | 5:00 PM | SEC Network |
| (10) Pittsburgh @ (7) Louisville | 5:00 PM | ESPN2 |
| (FFO) Indiana @ Washington | 5:00 PM | Peacock |
| Florida State @ (1) Duke | 6:00 PM | ACC Network |
| (3) Marquette @ Georgetown | 7:00 PM | Peacock |
| Oklahoma State @ (8) Baylor | 7:00 PM | ESPN+ |
| (9) Georgia @ (11) Texas | 7:00 PM | ESPN2 |
| (10) San Diego State @ Wyoming | 7:00 PM | |
| (4) Texas A&M @ (2) Florida | 7:30 PM | SEC Network |
| (5) Arizona @ (1) Iowa State | 8:00 PM | ESPN |
| (7) West Virginia @ (NFO) BYU | 9:00 PM | |
| Oregon State @ (9) Saint Mary's College | 9:00 PM | |
| Long Beach State @ (11) UC Irvine | 9:00 PM | |
| (6) Gonzaga @ San Francisco | 10:00 PM | ESPN |
March 2
| Missouri State @ (12) Drake | 0:00 | |
| (5) Wisconsin @ (3) Michigan State | 12:30 PM | CBS |
| (3) Illinois @ (5) Michigan | 2:45 PM | CBS |
| (6) Memphis @ UAB | 4:00 PM |
March 3
| Wake Forest @ (1) Duke | 6:00 PM | ESPN |
(12) McNeese @  Stephen F. Austin | 6:30 PM | |
| (2) Kansas @ (2) Houston | 8:00 PM | ESPN |
| (8) UCLA @ Northwestern | 8:00 PM | FS1 |
March 4
| (1) Auburn @ (4) Texas A&M | 0:00 | |
| LSU @ (4) Kentucky | 0:00 | |
| (9) Georgia @ South Carolina | 5:00 PM | SEC Network |
| Rutgers @ (3) Purdue | 6:00 PM | Peacock |
(6) Memphis @  UTSA | 6:00 PM | |
| (9) Creighton @ Seton Hall | 6:00 PM | FS1 |
| (10) North Carolina @ Virginia Tech | 6:00 PM | |
(12) VCU @  Duquesne | 6:00 PM | |
| (11) Texas @ (5) Mississippi State | 7:00 PM | SEC Network |
| (8) Baylor @ TCU | 7:00 PM | ESPN+ |
| (NFO) BYU @ (1) Iowa State | 8:00 PM | |
| (FFO) Indiana @ (4) Oregon | 8:00 PM | FS1 |
| (7) West Virginia @ Utah | 8:00 PM | ESPN+ |
| (11) New Mexico @ Nevada | 8:00 PM | |
| (11) Nebraska @ (11) Ohio State | 8:00 PM | Peacock |
| Syracuse @ (FFO) SMU | 8:00 PM | |
| Arkansas @ (11) Vanderbilt | 9:00 PM | SEC Network |
| Arizona State @ (5) Arizona | 10:00 PM | |
| (10) San Diego State @ UNLV | 10:00 PM |
March 5
| (9) Maryland @ (5) Michigan | 5:30 PM | BTN |
| (2) Florida @ (1) Alabama | 6:00 PM | |
| (7) Clemson @ Boston College | 6:00 PM | |
| (10) Pittsburgh @ North Carolina State | 6:00 PM | ACC Network |
| Kansas State @ (FFO) Cincinnati | 6:00 PM | ESPN+ |
| (FFO) Xavier @ Butler | 6:00 PM | CBSSN |
| Oklahoma State @ (NFO) UCF | 6:00 PM | ESPN+ |
| Colorado @ (6) Texas Tech | 7:00 PM | ESPN+ |
| (7) Missouri @ (10) Oklahoma | 7:00 PM | SECN+ |
| (3) Marquette @ (8) Connecticut | 7:30 PM | FS1 |
| (5) Wisconsin @ Minnesota | 7:30 PM | BTN |
| (2) Tennessee @ (4) Ole Miss | 8:00 PM | |
| California @ (7) Louisville | 8:00 PM | ACC Network |
March 6
| (3) Michigan State @ (NFO) Iowa | 7:00 PM | FS1 |
| (11) UC Irvine @ UC Davis | 8:00 PM |
March 7
| Dayton @ (12) VCU | 6:00 PM | ESPN2 |
| (3) Purdue @ (3) Illinois | 7:00 PM | FOX |
| South Florida @ (6) Memphis | 8:00 PM | ESPN2 |
| UNLV @ (11) New Mexico | 9:00 PM |
March 8
| (6) Saint John's @ (3) Marquette | 0:00 | |
| Seton Hall @ (8) Connecticut | 0:00 | |
| USC @ (8) UCLA | 0:00 | FOX |
| Butler @ (9) Creighton | 0:00 | |
| Providence @ (FFO) Xavier | 0:00 | |
| (4) Kentucky @ (7) Missouri | 11:00 AM | |
| (5) Mississippi State @ Arkansas | 11:00 AM | |
| (11) Vanderbilt @ (9) Georgia | 11:00 AM | ESPNU |
| (NFO) Penn State @ (5) Wisconsin | 12:00 PM | Peacock |
| (1) Iowa State @ Kansas State | 12:30 PM | CBS |
| (1) Alabama @ (1) Auburn | 1:00 PM | ESPN |
| South Carolina @ (2) Tennessee | 1:00 PM | SEC Network |
| Stanford @ (7) Louisville | 1:00 PM | ESPNU |
| Northwestern @ (9) Maryland | 2:00 PM | Peacock |
| (FFO) Cincinnati @ Oklahoma State | 2:00 PM | ESPN+ |
| (11) Ohio State @ (FFO) Indiana | 2:45 PM | CBS |
| (5) Arizona @ (2) Kansas | 3:00 PM | ESPN |
| (4) Texas A&M @ LSU | 3:00 PM | SEC Network |
| Air Force @ (8) Utah State | 3:00 PM | |
| (FFO) SMU @ Florida State | 3:00 PM | ESPNU |
| (NFO) UCF @ (7) West Virginia | 4:00 PM | ESPN+ |
| (4) Ole Miss @ (2) Florida | 5:00 PM | SEC Network |
| Virginia Tech @ (7) Clemson | 5:00 PM | ESPNU |
| Boston College @ (10) Pittsburgh | 5:00 PM | ACC Network |
| (1) Duke @ (10) North Carolina | 5:30 PM | ESPN |
| (10) Oklahoma @ (11) Texas | 7:00 PM | SEC Network |
| (2) Houston @ (8) Baylor | 8:00 PM | ESPN2 |
| (11) UC Irvine @ UC Santa Barbara | 9:00 PM | |
| (6) Texas Tech @ Arizona State | 9:30 PM | |
| Nevada @ (10) San Diego State | 9:30 PM | |
| Utah @ (NFO) BYU | 9:30 PM |
March 9
| (5) Michigan @ (3) Michigan State | 11:00 AM | CBS |
| (NFO) Iowa @ (11) Nebraska | 11:30 AM | FOX |
| (4) Oregon @ Washington | 2:00 PM | BTN |