November 3
 Texas Southern @ (1)  Gonzaga | 0:00 | |
 North Dakota @ (6)  Alabama | 0:00 | |
 Bethune-Cookman @ (6)  Auburn | 0:00 | |
(8)  Missouri @  Howard | 0:00 | |
 Canisius @ (11)  Dayton | 0:00 | |
 Quinnipiac @ (4)  Saint John's | 5:30 PM | FS1 |
 IU Indianapolis @ (7)  Ohio State | 5:30 PM | B1G+ |
(9)  Maryland v.  Coppin State | 5:30 PM | BTN |
(12)  High Point v. (14)  Furman | 5:30 PM | |
(1)  Florida v. (4)  Arizona | 6:00 PM | TNT |
 New Haven @ (1)  Connecticut | 6:00 PM | |
 Mercer @ (3)  Tennessee | 6:00 PM | |
 Colgate @ (6)  Michigan State | 6:00 PM | B1G+ |
 New Hampshire @ (8)  Clemson | 6:00 PM | |
(16)  Southern @ (9)  Arkansas | 6:00 PM | SEC Network |
 Central Arkansas @ (9)  North Carolina | 6:00 PM | ACC Network |
 Western Carolina @ (10)  Cincinnati | 6:00 PM | ESPN+ |
 Wagner @ (11)  VCU | 6:00 PM | |
 North Carolina Central @ (FFO)  North Carolina State | 6:00 PM | |
(15)  Youngstown State @ (NFO)  Pittsburgh | 6:00 PM |
November 4
 Evansville @ (2)  Purdue | 0:00 | BTN |
 Long Beach State @ (5)  San Diego State | 0:00 | |
 Hawaii @ (11)  Oregon | 0:00 | BTN |
 Robert Morris @ (FFO)  Iowa | 0:00 | BTN |
 Nicholls @ (2)  Kentucky | 6:00 PM | SECN+ |
 Lindenwood @ (4)  Texas Tech | 7:00 PM | ESPN+ |
(2)  Duke v. (11)  Texas | 7:45 PM | ESPN |
November 5
(16) Southern @ (10)  Marquette | 0:00 | |
 South Dakota @ (11)  Creighton | 0:00 | Peacock |
 Maryland Eastern Shore @ (FFO)  Georgia | 0:00 | |
 Alabama A&M @ (NFO)  Indiana | 7:00 PM | BTN |
 North Alabama @ (7)  Mississippi State | 8:00 PM | SEC Network |
November 6
 Merrimack @ (6) Auburn | 0:00 | |
Texas Southern @ (9)  Texas A&M | 0:00 | |
 Texas A&M-Corpus Christi @ (FFO)  SMU | 0:00 | |
 Jackson State @ (4)  Louisville | 6:00 PM | ACC Extra |
 North Florida @ (1) Florida | 7:00 PM | SECN+ |
 Grambling State @ (3)  Iowa State | 7:00 PM | ESPN+ |
November 7
 Oakland @ (2) Purdue | 0:00 | Peacock |
 Northern Illinois @ (6)  Wisconsin | 0:00 | BTN |
 Purdue Fort Wayne @ (7) Ohio State | 0:00 | BTN |
(7)  Utah State v. (11) VCU | 0:00 | |
 Georgetown @ (9) Maryland | 0:00 | FS1 |
 Rice @ (11) Oregon | 0:00 | B1G+ |
 Western Illinois @ (FFO) Iowa | 0:00 | B1G+ |
 Longwood @ (NFO) Pittsburgh | 0:00 | |
 Charleston @ (12)  Liberty | 0:00 | |
 Valparaiso @ (2) Kentucky | 6:00 PM | SECN+ |
 FGCU @ (2)  Illinois | 6:00 PM | Peacock |
(5)  Kansas @ (9) North Carolina | 6:00 PM | ESPN |
 Gardner-Webb @ (8) Clemson | 6:00 PM | ACC Network |
 Georgia State @ (10) Cincinnati | 6:00 PM | ESPN+ |
 UMass-Lowell @ (1) Connecticut | 6:30 PM | Peacock |
 ULM @ (7)  Ole Miss | 6:30 PM | |
 Sam Houston State @ (4) Texas Tech | 7:00 PM | ESPN+ |
 Southeast Missouri @ (8) Missouri | 7:00 PM | SECN+ |
(12)  Yale @ (16)  Navy | 7:30 PM | CBSSN |
 Utah Tech @ (4) Arizona | 8:00 PM | TNT |
 UAB @ (FFO) North Carolina State | 8:00 PM | ACC Network |
(12)  McNeese @  Santa Clara | 9:00 PM | |
 Pepperdine @ (3)  UCLA | 9:30 PM | BTN |
 Chattanooga @ (10)  Saint Mary's College | 10:30 PM |
November 8
 Oklahoma @ (1) Gonzaga | 0:00 | |
| Western Carolina @ (2) Duke | 0:00 | The CW Network |
 Northern Kentucky @ (3) Tennessee | 0:00 | |
| (6) Alabama @ (4) Saint John's | 0:00 | FS1 |
| (9) Arkansas @ (6) Michigan State | 0:00 | FOX |
(8)  Vanderbilt @  UCF | 0:00 | |
 San Francisco @ (10)  Memphis | 0:00 | |
 UMBC @ (11) Dayton | 0:00 | |
(14)  Utah Valley @ (11)  Boise State | 0:00 | |
 Queens @ (NFO)  Villanova | 0:00 | |
 FIU @ (NFO)  Nebraska | 12:00 PM | |
 Towson @ (1)  Houston | 2:00 PM | ESPN+ |
 Lafayette @ (11) Texas | 2:00 PM | |
 Holy Cross @ (5)  BYU | 8:00 PM | ESPN+ |
November 9
 Idaho State @ (5) San Diego State | 0:00 | |
 Morehead State @ (FFO) Georgia | 0:00 | |
 FAU @ (12) Liberty | 0:00 | |
| (10) Marquette v. (NFO) Indiana | 12:00 PM | |
 VMI @ (8) Missouri | 1:00 PM | SECN+ |
(9) Texas A&M @  Oklahoma State | 1:00 PM | ESPN2 |
 Manhattan @ (8)  USC | 5:00 PM | |
 Washington @ (5)  Baylor | 7:30 PM | ESPN |
November 10
 Eastern Michigan @ (NFO) Pittsburgh | 0:00 | |
 Columbia @ (1) Connecticut | 5:30 PM | |
| (3) Iowa State v. (7) Mississippi State | 7:00 PM | ESPNU |
 West Georgia @ (3) UCLA | 9:00 PM |
November 11
| (11) Creighton @ (1) Gonzaga | 0:00 | |
(2) Duke @  Army | 0:00 | |
(3)  Michigan v.  Wake Forest | 0:00 | |
 Ball State @ (6) Wisconsin | 0:00 | |
 Wofford @ (6) Auburn | 0:00 | |
 Appalachian State @ (7) Ohio State | 0:00 | |
| Morehead State @ (8) Clemson | 0:00 | |
 Alcorn State @ (9) Maryland | 0:00 | |
| Central Arkansas @ (9) Arkansas | 0:00 | |
 UTRGV @ (11) Boise State | 0:00 | |
 Murray State @ (FFO) SMU | 0:00 | |
 Sacred Heart @ (NFO) Villanova | 0:00 | |
 Florida State @ (1) Florida | 6:00 PM | SEC Network |
 Radford @ (9) North Carolina | 6:00 PM | ACC Network |
| (11) Dayton @ (10) Cincinnati | 6:00 PM | ESPN+ |
 Jacksonville @ (12) High Point | 6:00 PM | |
| (12) Yale @ Quinnipiac | 6:30 PM | |
| (2) Kentucky @ (4) Louisville | 7:00 PM | ESPN |
| Texas A&M-Corpus Christi @ (5) Kansas | 7:00 PM | ESPN+ |
| Maryland Eastern Shore @ (NFO) Nebraska | 7:00 PM | B1G+ |
| (4) Texas Tech @ (2) Illinois | 7:30 PM | FS1 |
 Northern Arizona @ (4) Arizona | 8:00 PM | ESPN+ |
 Delaware @ (5) BYU | 8:00 PM | CBSSN |
| (10) Memphis @ (7) Ole Miss | 8:00 PM | SEC Network |
 Ohio @ (10) Saint Mary's College | 9:00 PM |
November 12
| North Florida @ (3) Tennessee | 0:00 | |
 Weber State @ (7) Utah State | 0:00 | |
 Eastern Kentucky @ (8) Vanderbilt | 0:00 | |
(15)  Little Rock @ (10) Marquette | 0:00 | |
 South Dakota State @ (11) Oregon | 0:00 | |
 Fairleigh Dickinson @ (11) Texas | 0:00 | |
 Saint Peter's @ (11) VCU | 0:00 | |
 Milwaukee @ (NFO) Indiana | 0:00 | |
| Oakland @ (1) Houston | 7:00 PM | ESPN+ |
 Minnesota @ (8) Missouri | 7:00 PM | SECN+ |
 UNCG @ (FFO) North Carolina State | 7:00 PM | ACC Network |
November 13
 San Jose State @ (6) Michigan State | 0:00 | |
(NFO) Pittsburgh @  West Virginia | 0:00 | |
| (2) Purdue @ (6) Alabama | 6:00 PM | ESPN2 |
November 14
| Colgate @ (2) Illinois | 0:00 | |
| UCF @ (9) Texas A&M | 0:00 | |
 Samford @ (9) Arkansas | 0:00 | |
| Maryland Eastern Shore @ (11) Creighton | 0:00 | |
 Xavier @ (FFO) Iowa | 0:00 | |
| (12) High Point @ UAB | 0:00 | |
 North Texas @ (10) Saint Mary's College | 12:00 PM | |
 Indiana State @ (2) Duke | 6:00 PM | ACC Network |
 Eastern Illinois @ (2) Kentucky | 6:00 PM | SECN+ |
 Louisiana @ (12) McNeese | 6:00 PM | |
 Cal State Bakersfield @ (7) Ole Miss | 6:30 PM | |
(8) USC v.  Illinois State | 6:30 PM | |
| Milwaukee @ (4) Texas Tech | 7:00 PM | ESPN+ |
(3) Michigan @  TCU | 8:00 PM | ESPN2 |
 Tarleton State @ (5) Baylor | 8:00 PM | ESPN+ |
| North Carolina Central @ (9) North Carolina | 8:00 PM | ACC Network |
 Georgia Tech @ (FFO) Georgia | 8:00 PM | SEC Network |
| (3) UCLA v. (4) Arizona | 9:00 PM | Peacock |
(1) Gonzaga @  Arizona State | 10:00 PM | ESPN2 |
November 15
 William & Mary @ (4) Saint John's | 0:00 | |
| Ohio @ (4) Louisville | 0:00 | |
 Southeastern Louisiana @ (7) Mississippi State | 0:00 | |
 UTEP @ (7) Utah State | 0:00 | |
 Arkansas-Pine Bluff @ (8) Vanderbilt | 0:00 | |
| (8) Clemson @ Georgetown | 0:00 | |
| (9) Maryland @ (10) Marquette | 0:00 | |
| Bethune-Cookman @ (11) Dayton | 0:00 | |
 UMKC @ (11) Texas | 0:00 | |
 Montana State @ (11) Boise State | 0:00 | |
 Butler @ (FFO) SMU | 0:00 | |
 Duquesne @ (NFO) Villanova | 0:00 | |
 Stony Brook @ (12) Yale | 12:00 PM | |
 Princeton @ (5) Kansas | 1:00 PM | ESPN+ |
| (1) Connecticut v. (5) BYU | 6:00 PM | FOX |
| (NFO) Nebraska v. Oklahoma | 6:00 PM |
November 16
(13)  Akron @ (2) Purdue | 0:00 | |
 Notre Dame @ (7) Ohio State | 0:00 | |
 UNLV @ (10) Memphis | 0:00 | |
 Incarnate Word @ (NFO) Indiana | 0:00 | |
| (1) Houston v. (6) Auburn | 2:00 PM | ESPN |
 Mount Saint Mary's @ (10) Cincinnati | 5:00 PM | ESPN+ |
(1) Florida v.  Miami (FL) | 7:30 PM | ESPN |
November 17
 Southern Utah @ (1) Gonzaga | 0:00 | |
 SIUE @ (6) Wisconsin | 0:00 | |
 Oregon State @ (11) Oregon | 0:00 | |
 Florida A&M @ (FFO) Georgia | 5:30 PM | SEC Network |
| (11) VCU @ (FFO) North Carolina State | 6:00 PM | ACC Network |
 Bucknell @ (NFO) Pittsburgh | 6:00 PM | |
| Canisius @ (12) High Point | 6:00 PM | |
 Stonehill @ (3) Iowa State | 7:00 PM | ESPN+ |
 Prairie View A&M @ (8) Missouri | 7:00 PM | SECN+ |
| Rice @ (3) Tennessee | 7:30 PM | SEC Network |
| North Alabama @ (8) Clemson | 8:00 PM | ACC Network |
November 18
(14)  Troy @ (5) San Diego State | 0:00 | |
 Montana @ (9) Texas A&M | 0:00 | |
 Wichita State @ (11) Boise State | 0:00 | |
| Arkansas-Pine Bluff @ (FFO) SMU | 0:00 | |
| Southeast Missouri @ (FFO) Iowa | 0:00 | |
| (2) Kentucky v. (6) Michigan State | 5:30 PM | ESPN |
| (16) Navy @ (9) North Carolina | 6:00 PM | ACC Network |
 Austin Peay @ (7) Ole Miss | 7:00 PM | |
 Winthrop @ (9) Arkansas | 7:00 PM | SECN+ |
 Rhode Island @ (12) Yale | 7:00 PM | |
| (2) Duke v. (5) Kansas | 8:00 PM | ESPN |
 Rider @ (11) Texas | 8:00 PM | SEC Network |
 Sacramento State @ (3) UCLA | 9:30 PM |
November 19
| (2) Illinois v. (6) Alabama | 0:00 | |
 Middle Tennessee @ (3) Michigan | 0:00 | |
| Mount Saint Mary's @ (9) Maryland | 0:00 | |
| (11) Dayton @ (10) Marquette | 0:00 | |
| North Dakota @ (11) Creighton | 0:00 | |
(NFO) Villanova @  La Salle | 0:00 | |
 Arkansas State @ (10) Saint Mary's College | 12:00 PM | |
| (4) Arizona @ (1) Connecticut | 6:00 PM | FS1 |
| Jackson State @ (6) Auburn | 8:00 PM | SEC Network |
November 20
 Tennessee State @ (3) Tennessee | 0:00 | |
 Western Michigan @ (7) Ohio State | 0:00 | |
| Texas Southern @ (8) Vanderbilt | 0:00 | |
| South Dakota @ (8) Missouri | 0:00 | |
 Chicago State @ (FFO) Iowa | 0:00 | |
| Lindenwood @ (NFO) Indiana | 0:00 | |
(12) High Point v.  UIC | 1:30 PM | |
| (2) Purdue v. (10) Memphis | 5:00 PM | |
| Bucknell @ (4) Saint John's | 6:00 PM | |
| (NFO) Pittsburgh v. UCF | 6:00 PM | ESPN2 |
(NFO) Nebraska v.  New Mexico | 6:00 PM | Peacock |
| (4) Texas Tech v. Wake Forest | 7:30 PM | CBSSN |
| Rider @ (1) Houston | 8:00 PM | TNT |
(7) Mississippi State @  Kansas State | 8:30 PM | Peacock |
| (14) Troy @ (8) USC | 9:00 PM |
November 21
 Detroit @ (6) Michigan State | 0:00 | |
| Manhattan @ (9) Texas A&M | 0:00 | |
| Jackson State @ (9) Arkansas | 0:00 | |
(12) Yale v.  Green Bay | 11:30 AM | |
(7) Utah State v.  Tulane | 12:00 PM | |
| (6) Wisconsin @ (5) BYU | 3:00 PM | Peacock |
| (4) Louisville @ (10) Cincinnati | 5:30 PM | |
| (8) Clemson v. West Virginia | 5:30 PM | |
| Merrimack @ (1) Florida | 6:00 PM | SECN+ |
 Niagara @ (2) Duke | 6:00 PM | ACC Network |
 Loyola-Maryland @ (2) Kentucky | 6:00 PM | SECN+ |
| Arkansas State @ (FFO) SMU | 8:00 PM | ACC Network |
| (FFO) Georgia v. Xavier | 8:00 PM | ESPN2 |
 Presbyterian College @ (3) UCLA | 9:30 PM |
November 22
 Long Island @ (2) Illinois | 0:00 | |
 Central Michigan @ (10) Marquette | 0:00 | |
| North Carolina Central @ (11) Dayton | 0:00 | |
| Coppin State @ (11) VCU | 0:00 |
November 23
| Quinnipiac @ (NFO) Pittsburgh | 0:00 | |
| Howard @ (2) Duke | 3:00 PM | ACC Network |
(12) McNeese v.  George Washington | 4:00 PM | |
 Bryant @ (1) Connecticut | 5:00 PM |
November 24
| UTRGV @ (2) Illinois | 0:00 | |
 New Orleans @ (7) Mississippi State | 0:00 | |
| Radford @ (FFO) SMU | 0:00 | |
(3) Tennessee v.  Rutgers | 12:00 PM | |
(12) Liberty v. (16)  Vermont | 12:30 PM | |
| (5) Baylor v. (11) Creighton | 1:00 PM | |
(FFO) North Carolina State v.  Seton Hall | 1:30 PM | ESPN2 |
| (5) Kansas v. Notre Dame | 2:30 PM | TNT |
| (3) Iowa State v. (4) Saint John's | 3:30 PM | truTV |
| (8) USC v. (11) Boise State | 4:00 PM | |
(1) Houston v.  Syracuse | 5:00 PM | |
| Eastern Michigan @ (4) Louisville | 6:00 PM | ACC Network |
 NJIT @ (10) Cincinnati | 6:00 PM | ESPN+ |
| (12) McNeese v. Murray State | 6:30 PM | |
| (6) Auburn v. (11) Oregon | 7:00 PM | |
| (1) Gonzaga v. (6) Alabama | 8:30 PM | |
| (3) Michigan v. (5) San Diego State | 9:30 PM | |
 Denver @ (4) Arizona | 9:30 PM | CBSSN |
| (11) Texas v. Arizona State | 10:30 PM | ESPN2 |
| (9) Maryland v. UNLV | 10:59 PM |
November 25
| Mount Saint Mary's @ (7) Ohio State | 0:00 | |
 Mississippi Valley State @ (9) Texas A&M | 0:00 | |
 Old Dominion @ (NFO) Villanova | 0:00 | |
| Winthrop @ (NFO) Nebraska | 0:00 | BTN |
(6) Michigan State v.  East Carolina | 12:00 PM | FS2 |
| (3) Iowa State v. (11) Creighton | 1:30 PM | truTV |
| (5) Kansas v. Syracuse | 2:30 PM | TNT |
| (1) Houston v. (3) Tennessee | 4:00 PM | |
| (4) Saint John's v. (5) Baylor | 4:00 PM | truTV |
| (12) McNeese v. Middle Tennessee | 4:00 PM | |
(9) North Carolina v.  Saint Bonaventure | 5:00 PM | FS1 |
 South Carolina State @ (8) Missouri | 7:00 PM | SECN+ |
| Kansas State @ (NFO) Indiana | 7:00 PM | FS1 |
| (3) Michigan v. (6) Auburn | 7:30 PM | |
| (1) Gonzaga v. (9) Maryland | 8:30 PM | |
| (7) Ole Miss v. (FFO) Iowa | 8:30 PM | |
(3) UCLA v.  California | 9:00 PM | ESPN |
| (5) San Diego State v. (11) Oregon | 10:00 PM | |
| (6) Alabama v. UNLV | 10:59 PM |
November 26
 Southern Illinois @ (10) Memphis | 0:00 | |
(8) Vanderbilt v.  Western Kentucky | 11:00 AM | |
| New Orleans @ (4) Texas Tech | 12:00 PM | ESPN+ |
(11) VCU v.  South Florida | 1:30 PM | |
 Tennessee Tech @ (2) Kentucky | 6:00 PM | SEC Network |
| Eastern Michigan @ (10) Cincinnati | 6:00 PM | ESPN+ |
| (10) Saint Mary's College v. Wichita State | 6:30 PM | |
| NJIT @ (4) Louisville | 8:00 PM | ACC Network |
November 27
| (1) Florida v. TCU | 2:00 PM | FS1 |
| (6) Michigan State v. (9) North Carolina | 3:30 PM | FOX |
| (5) BYU v. Miami (FL) | 4:00 PM | ESPN |
(6) Wisconsin v.  Providence | 4:30 PM | |
| (11) Dayton v. Georgetown | 6:30 PM | |
| (2) Duke v. (9) Arkansas | 7:00 PM |
November 28
| Eastern Illinois @ (2) Purdue | 0:00 | |
| (FFO) SMU @ (7) Mississippi State | 0:00 | |
| Alabama A&M @ (8) Clemson | 0:00 | |
 Cleveland State @ (8) Missouri | 0:00 | |
| (10) Marquette v. Oklahoma | 0:00 | |
| (1) Connecticut v. (2) Illinois | 11:30 AM | |
| (9) Texas A&M v. Florida State | 4:00 PM | ESPN2 |
| (7) Ohio State @ (NFO) Pittsburgh | 6:00 PM | ESPN |
November 29
| Montana State @ (7) Utah State | 0:00 | |
| Tennessee Tech @ (FFO) Georgia | 0:00 | |
| Bethune-Cookman @ (NFO) Indiana | 0:00 | |
| Western Carolina @ (12) High Point | 1:00 PM | |
(16)  Norfolk State @ (4) Arizona | 3:00 PM | ESPN+ |
 South Carolina Upstate @ (NFO) Nebraska | 7:30 PM | B1G+ |
November 30
| (12) Yale @ (16) Vermont | 0:00 | |
 Wyoming @ (4) Texas Tech | 2:00 PM | ESPN+ |
December 1
 Temple @ (NFO) Villanova | 0:00 | |
| (12) McNeese @ Incarnate Word | 0:00 | |
| Tarleton State @ (10) Cincinnati | 6:00 PM | ESPN+ |
December 2
| (2) Purdue @ Rutgers | 0:00 | |
| (FFO) Iowa @ (6) Michigan State | 0:00 | |
| Wagner @ (9) Maryland | 0:00 | |
| Valparaiso @ (10) Marquette | 0:00 | |
 East Tennessee State @ (11) Dayton | 0:00 | |
| Nicholls @ (11) Creighton | 0:00 | |
| (3) Tennessee @ Syracuse | 6:00 PM | ESPN2 |
| (9) Texas A&M @ (NFO) Pittsburgh | 6:00 PM | ESPNU |
| (1) Florida @ (2) Duke | 6:30 PM | ESPN |
| Sacramento State @ (5) Baylor | 7:00 PM | ESPN+ |
| (1) Connecticut @ (5) Kansas | 8:00 PM | ESPN2 |
| Miami (FL) @ (7) Ole Miss | 8:00 PM | SEC Network |
| (8) Missouri @ Notre Dame | 8:00 PM | ESPNU |
| (FFO) Georgia @ Florida State | 8:00 PM | ACC Network |
| (9) North Carolina @ (2) Kentucky | 8:30 PM | ESPN |
| (8) USC @ (11) Oregon | 9:00 PM |
December 3
| (14) Utah Valley @ (5) San Diego State | 0:00 | |
 Northwestern @ (6) Wisconsin | 0:00 | |
| New Orleans @ (10) Memphis | 0:00 | |
| (NFO) Indiana @ Minnesota | 0:00 | |
| (4) Louisville @ (9) Arkansas | 6:00 PM | ESPN |
| (8) Clemson @ (6) Alabama | 6:00 PM | ESPNU |
| Southern Illinois @ (12) High Point | 6:00 PM | |
| Alcorn State @ (3) Iowa State | 7:00 PM | ESPN+ |
 California Baptist @ (5) BYU | 8:00 PM | ESPN+ |
| (FFO) North Carolina State @ (6) Auburn | 8:00 PM | ESPN |
| (7) Mississippi State @ Georgia Tech | 8:00 PM | ACC Network |
| (FFO) SMU @ (8) Vanderbilt | 8:00 PM | SEC Network |
 Virginia @ (11) Texas | 8:00 PM | ESPNU |
| (3) UCLA @ Washington | 10:00 PM |
December 4
| (7) Utah State @ South Florida | 0:00 |
December 5
| Samford @ (11) VCU | 0:00 | |
| (1) Gonzaga @ (2) Kentucky | 6:00 PM | ESPN2 |
| NJIT @ (12) High Point | 6:00 PM | |
 East Texas A&M @ (1) Connecticut | 6:30 PM | |
| (10) Cincinnati @ Xavier | 6:30 PM | |
 Northwestern State @ (12) McNeese | 6:30 PM |
December 6
| (2) Duke @ (6) Michigan State | 0:00 | |
| Rutgers @ (3) Michigan | 0:00 | |
| (7) Ole Miss @ (4) Saint John's | 0:00 | |
| (10) Marquette @ (6) Wisconsin | 0:00 | |
| (7) Ohio State @ Northwestern | 0:00 | |
| (9) Maryland @ (FFO) Iowa | 0:00 | |
 Fresno State @ (9) Arkansas | 0:00 | |
| (11) Boise State @ Butler | 0:00 | |
 UNC Asheville @ (FFO) North Carolina State | 0:00 | |
| Coppin State @ (12) Liberty | 0:00 | |
| (3) Iowa State @ (2) Purdue | 11:00 AM | CBS |
| (11) Dayton v. Virginia | 11:00 AM | ESPN2 |
| (4) Louisville @ (NFO) Indiana | 1:00 PM | |
| (5) Baylor @ (10) Memphis | 3:30 PM | CBS |
| (11) Oregon @ (3) UCLA | 5:00 PM | |
| Washington @ (8) USC | 5:00 PM |
December 7
| North Florida @ (1) Gonzaga | 0:00 | |
(10) Saint Mary's College @  Davidson | 0:00 | |
| (8) Missouri @ (5) Kansas | 12:00 PM | ESPN2 |
 UTSA @ (6) Alabama | 1:00 PM | SEC Network |
| (11) Creighton @ (NFO) Nebraska | 1:00 PM | FS1 |
| UIC @ (12) Yale | 1:00 PM | |
(4) Texas Tech v.  LSU | 2:00 PM | ESPN2 |
| (7) Mississippi State v. San Francisco | 3:00 PM | SEC Network |
(7) Utah State @  Charlotte | 3:00 PM | |
 Hofstra @ (NFO) Pittsburgh | 3:00 PM | |
| (9) Texas A&M v. (FFO) SMU | 4:00 PM | ESPN2 |
| Georgetown @ (9) North Carolina | 4:00 PM | ESPN |
December 8
| (16) Southern @ (11) Texas | 7:00 PM | SEC Network |
December 9
| (2) Illinois @ (7) Ohio State | 0:00 | |
| (NFO) Villanova @ (3) Michigan | 0:00 | |
| (12) McNeese @ Rhode Island | 0:00 | |
| (5) BYU v. (8) Clemson | 5:30 PM | ESPN |
| North Carolina Central @ (2) Kentucky | 6:00 PM | SEC Network |
 Penn State @ (NFO) Indiana | 7:30 PM | FS1 |
| (1) Florida v. (1) Connecticut | 8:00 PM | ESPN |
(8) USC @  San Diego | 9:00 PM |
December 10
| Minnesota @ (2) Purdue | 0:00 | |
 Lamar @ (5) San Diego State | 0:00 | |
| New Mexico @ (11) VCU | 0:00 | |
| Duquesne @ (11) Boise State | 0:00 | |
| (16) Norfolk State @ (5) Baylor | 11:00 AM | ESPN+ |
(12) Yale v.  Albany | 3:30 PM | |
| (6) Wisconsin @ (NFO) Nebraska | 4:00 PM | BTN |
| (12) Liberty @ (FFO) North Carolina State | 6:00 PM | ACC Network |
| Jackson State @ (1) Houston | 7:00 PM | ESPN+ |
December 11
 Alabama State @ (8) Missouri | 0:00 | |
| (FFO) Iowa @ (3) Iowa State | 7:00 PM | FS1 |
December 12
| (11) Texas @ (1) Connecticut | 7:00 PM | |
| East Texas A&M @ (12) McNeese | 7:30 PM |
December 13
| (3) UCLA @ (1) Gonzaga | 0:00 | |
| (10) Marquette @ (2) Purdue | 0:00 | |
| (3) Michigan @ (9) Maryland | 0:00 | |
 Iona @ (4) Saint John's | 0:00 | |
| (7) Utah State v. Illinois State | 0:00 | |
| Mercer @ (8) Clemson | 0:00 | |
| South Carolina Upstate @ (9) North Carolina | 0:00 | |
| North Florida @ (11) Dayton | 0:00 | |
 UC Davis @ (11) Oregon | 0:00 | |
| (NFO) Pittsburgh @ (NFO) Villanova | 0:00 | |
| (4) Texas Tech v. (9) Arkansas | 11:00 AM | ESPN2 |
| (6) Michigan State @ Penn State | 11:00 AM | BTN |
| (10) Cincinnati v. (FFO) Georgia | 1:00 PM | ESPNU |
| (1) Florida v. George Washington | 1:30 PM | ESPN2 |
| New Orleans @ (1) Houston | 2:00 PM | ESPN+ |
(7) Ole Miss v.  Southern Miss | 2:00 PM | |
| Kansas State @ (11) Creighton | 2:00 PM | FOX |
| (10) Memphis @ (4) Louisville | 2:30 PM | ESPN |
| (6) Auburn v. Chattanooga | 3:30 PM | SEC Network |
| (5) Kansas @ (FFO) North Carolina State | 4:30 PM | ESPN |
| Central Arkansas @ (8) Vanderbilt | 5:30 PM | SEC Network |
| (NFO) Indiana @ (2) Kentucky | 6:30 PM | ESPN |
| (7) Ohio State v. West Virginia | 7:00 PM | ESPNU |
| (FFO) SMU v. LSU | 7:30 PM | SEC Network |
| (NFO) Nebraska @ (2) Illinois | 8:00 PM | Peacock |
 UC Riverside @ (5) BYU | 8:00 PM | ESPN+ |
| (4) Arizona v. (6) Alabama | 8:30 PM | ESPN |
December 14
| (10) Saint Mary's College v. (11) Boise State | 0:00 | |
| Western Michigan @ (FFO) Iowa | 0:00 | |
| (12) High Point v. Appalachian State | 0:00 | |
| Eastern Illinois @ (3) Iowa State | 12:00 PM | ESPN+ |
| Bethune-Cookman @ (8) Missouri | 1:00 PM | SEC Network |
| Jacksonville @ (9) Texas A&M | 6:00 PM | SEC Network |
 Washington State @ (8) USC | 6:30 PM |
December 15
| Niagara @ (11) VCU | 0:00 | |
(12) McNeese @  Houston Christian | 7:00 PM |
December 16
 DePaul @ (4) Saint John's | 0:00 | |
 Toledo @ (6) Michigan State | 0:00 | |
| Long Island @ (7) Mississippi State | 0:00 | |
| Florida State @ (11) Dayton | 0:00 | |
 Le Moyne @ (11) Texas | 0:00 | |
(15)  Lipscomb @ (2) Duke | 5:00 PM | ACC Network |
| (4) Louisville @ (3) Tennessee | 6:00 PM | ESPN |
 South Carolina @ (8) Clemson | 6:00 PM | ESPN2 |
(15)  Northern Colorado @ (4) Texas Tech | 7:00 PM | ESPN+ |
| East Tennessee State @ (9) North Carolina | 7:00 PM | ACC Network |
| Butler @ (1) Connecticut | 7:30 PM | |
 Abilene Christian @ (4) Arizona | 8:00 PM | ESPN+ |
| Towson @ (5) Kansas | 8:00 PM | ESPN |
 Pacific @ (5) BYU | 8:00 PM | ESPN+ |
| Queens @ (9) Arkansas | 8:00 PM | SEC Network |
December 17
 Campbell @ (1) Gonzaga | 0:00 | |
 Air Force @ (5) San Diego State | 0:00 | |
| South Florida @ (6) Alabama | 0:00 | |
| (8) Vanderbilt @ (10) Memphis | 0:00 | |
| Georgetown @ (10) Marquette | 0:00 | |
 Portland @ (11) Oregon | 0:00 | |
| (11) Creighton @ Xavier | 0:00 | |
| Texas Southern @ (FFO) North Carolina State | 0:00 | |
 Binghamton @ (NFO) Pittsburgh | 0:00 | |
 Saint Francis (PA) @ (1) Florida | 5:30 PM | SEC Network |
| Alabama State @ (10) Cincinnati | 6:00 PM | ESPN+ |
| (7) Ole Miss v. Alabama A&M | 7:00 PM | |
| UTSA @ (8) USC | 8:00 PM | |
| Arizona State @ (3) UCLA | 9:30 PM | FS1 |
December 18
 American @ (11) VCU | 0:00 | |
| Western Carolina @ (FFO) Georgia | 0:00 |
December 19
| La Salle @ (12) High Point | 6:00 PM | |
| Alcorn State @ (5) Baylor | 7:00 PM | ESPN+ |
| (6) Wisconsin v. (NFO) Villanova | 7:00 PM | |
| Abilene Christian @ (5) BYU | 8:30 PM | TNT |
 Cal Poly @ (3) UCLA | 9:00 PM | |
| FAU @ (10) Saint Mary's College | 9:00 PM |
December 20
| (6) Michigan State v. Oakland | 0:00 | |
 Colorado State @ (7) Utah State | 0:00 | |
| (10) Marquette @ (11) Creighton | 0:00 | |
| (12) Liberty @ (11) Dayton | 0:00 | |
(11) Boise State @  Nevada | 0:00 | |
| Chicago State @ (NFO) Indiana | 0:00 | |
| Montana @ (4) Louisville | 11:00 AM | ACC Network |
| (2) Kentucky v. (4) Saint John's | 11:30 AM | CBS |
| (10) Memphis @ (7) Mississippi State | 1:00 PM | ESPN2 |
| (7) Ohio State v. (9) North Carolina | 2:00 PM | |
| (1) Houston v. (9) Arkansas | 4:30 PM | CBS |
| (9) Maryland @ Virginia | 5:00 PM | ESPN |
| (FFO) Iowa v. Bucknell | 5:00 PM | |
| (2) Purdue v. (6) Auburn | 5:30 PM | |
| (2) Duke v. (4) Texas Tech | 7:00 PM | ESPN |
| (4) Arizona v. (5) San Diego State | 9:30 PM | ESPN2 |
December 21
| (1) Gonzaga v. (11) Oregon | 0:00 | |
| Gardner-Webb @ (3) Tennessee | 0:00 | |
(6) Alabama v.  Kennesaw State | 0:00 | |
| (8) Vanderbilt @ Wake Forest | 0:00 | |
| East Texas A&M @ (9) Texas A&M | 0:00 | |
| Central Arkansas @ (FFO) SMU | 0:00 | |
| Colgate @ (1) Florida | 11:00 AM | SECN+ |
| (NFO) Pittsburgh v. Penn State | 11:00 AM | BTN |
| (16) Southern @ (5) Baylor | 12:00 PM | TNT |
| (7) Ole Miss v. (FFO) North Carolina State | 12:00 PM | ESPN |
| (8) Clemson v. (10) Cincinnati | 2:00 PM | ESPN |
| La Salle @ (3) Michigan | 3:00 PM | |
 Brown @ (8) USC | 3:00 PM | |
| (1) Connecticut @ DePaul | 3:30 PM | |
| Long Beach State @ (3) Iowa State | 5:00 PM | ESPN+ |
| North Dakota @ (NFO) Nebraska | 7:00 PM | BTN |
December 22
| (2) Illinois v. (8) Missouri | 0:00 | |
| Central Michigan @ (6) Wisconsin | 0:00 | |
| Alabama State @ (10) Memphis | 0:00 | |
| Maryland Eastern Shore @ (11) Texas | 0:00 | |
| Rider @ (11) VCU | 0:00 | |
| West Georgia @ (FFO) Georgia | 0:00 | |
 Siena @ (NFO) Indiana | 0:00 | |
| Bryant @ (12) High Point | 6:00 PM | |
| Davidson @ (5) Kansas | 7:00 PM | ESPN+ |
| East Carolina @ (9) North Carolina | 7:00 PM | ACC Network |
| Utah Tech @ (11) Creighton | 7:00 PM | |
| Bethune-Cookman @ (4) Arizona | 8:00 PM | ESPN+ |
 Eastern Washington @ (5) BYU | 8:00 PM | ESPN+ |
 Northern Iowa @ (10) Saint Mary's College | 9:00 PM |
December 23
 Harvard @ (4) Saint John's | 0:00 | |
| Grambling State @ (7) Ohio State | 0:00 | |
| (NFO) Villanova @ Seton Hall | 0:00 | |
 Bellarmine @ (2) Kentucky | 12:00 PM | SECN+ |
| UC Riverside @ (3) UCLA | 3:00 PM |
December 28
| (1) Gonzaga @ Pepperdine | 0:00 | |
| Old Dominion @ (9) Maryland | 0:00 | |
(10) Saint Mary's College @  Loyola-Marymount | 0:00 | |
 Omaha @ (11) Oregon | 0:00 | |
| (12) Liberty @ FIU | 0:00 | |
| Winthrop @ (4) Texas Tech | 1:00 PM | TNT |
 Cal State Fullerton @ (FFO) SMU | 2:00 PM |
December 29
 Kent State @ (2) Purdue | 0:00 | |
| (16) Southern @ (2) Illinois | 0:00 | |
| (12) McNeese @ (3) Michigan | 0:00 | |
| (12) Yale @ (6) Alabama | 0:00 | |
 Cornell @ (6) Michigan State | 0:00 | |
| Alabama State @ (7) Mississippi State | 0:00 | |
| New Haven @ (8) Vanderbilt | 0:00 | |
| Prairie View A&M @ (9) Texas A&M | 0:00 | |
 James Madison @ (9) Arkansas | 0:00 | |
| Long Island @ (FFO) Georgia | 0:00 | |
| UMass-Lowell @ (FFO) Iowa | 0:00 | |
 Dartmouth @ (1) Florida | 5:00 PM | SEC Network |
| (15) Lipscomb @ (10) Cincinnati | 6:00 PM | ESPN+ |
| Middle Tennessee @ (1) Houston | 7:00 PM | ESPN+ |
| Houston Christian @ (3) Iowa State | 7:00 PM | ESPN+ |
| Alcorn State @ (7) Ole Miss | 7:00 PM | SEC Network |
| South Dakota State @ (4) Arizona | 8:00 PM | ESPN+ |
| Queens @ (6) Auburn | 9:00 PM | SEC Network |
December 30
| (1) Gonzaga @ San Diego | 0:00 | |
| (5) San Diego State @ San Jose State | 0:00 | |
| Milwaukee @ (6) Wisconsin | 0:00 | |
| (7) Utah State @ Fresno State | 0:00 | |
| (10) Saint Mary's College @ Pepperdine | 0:00 | |
| Seton Hall @ (10) Marquette | 0:00 | |
| Butler @ (11) Creighton | 0:00 | |
| New Mexico @ (11) Boise State | 0:00 | |
| Florida State @ (9) North Carolina | 6:00 PM | ESPN2 |
| (NFO) Pittsburgh @ Miami (FL) | 6:00 PM | ACC Network |
| South Carolina State @ (3) Tennessee | 7:00 PM | SEC Network |
| (4) Louisville @ California | 8:00 PM | ACC Network |
| New Hampshire @ (NFO) Nebraska | 8:00 PM | BTN |
December 31
| (4) Saint John's @ Georgetown | 0:00 | |
| North Texas @ (10) Memphis | 0:00 | |
| Saint Bonaventure @ (11) VCU | 0:00 | |
| DePaul @ (NFO) Villanova | 0:00 | |
| (12) High Point @ UNC Asheville | 0:00 | |
| Wake Forest @ (FFO) North Carolina State | 11:00 AM | ESPN2 |
| (8) Clemson @ Syracuse | 1:00 PM | ESPN2 |
 Fordham @ (11) Dayton | 1:00 PM | |
| Georgia Tech @ (2) Duke | 3:00 PM | ACC Network |
| (1) Connecticut @ Xavier | 4:00 PM |
January 2
 Seattle University @ (1) Gonzaga | 0:00 | |
| (7) Ohio State @ Rutgers | 0:00 | |
| (11) Oregon @ (9) Maryland | 0:00 | |
| Portland @ (10) Saint Mary's College | 0:00 | |
| Kennesaw State @ (12) Liberty | 0:00 | |
| (8) USC @ (3) Michigan | 6:00 PM | |
(4) Louisville @  Stanford | 7:00 PM | ACC Network |
| West Virginia @ (3) Iowa State | 8:00 PM | ESPN2 |
| (6) Michigan State @ (NFO) Nebraska | 8:00 PM | Peacock |
January 3
| (2) Duke @ Florida State | 0:00 | |
| (2) Purdue @ (6) Wisconsin | 0:00 | |
| Providence @ (4) Saint John's | 0:00 | |
| (11) Boise State @ (5) San Diego State | 0:00 | |
| San Jose State @ (7) Utah State | 0:00 | |
| (8) Clemson @ (NFO) Pittsburgh | 0:00 | |
| (9) North Carolina @ (FFO) SMU | 0:00 | |
| (10) Memphis @ Rice | 0:00 | |
(11) Dayton @  Loyola-Chicago | 0:00 | |
| (11) VCU @ Duquesne | 0:00 | |
| (NFO) Villanova @ Butler | 0:00 | |
| Virginia @ (FFO) North Carolina State | 10:00 AM | ESPN2 |
| (2) Kentucky @ (6) Alabama | 12:00 PM | ESPN |
| Oklahoma State @ (4) Texas Tech | 12:00 PM | ESPN2 |
| (6) Auburn @ (FFO) Georgia | 12:00 PM | SEC Network |
| (5) BYU @ Kansas State | 12:30 PM | CBS |
| (1) Houston @ (10) Cincinnati | 1:00 PM | FOX |
| (5) Kansas @ UCF | 1:00 PM | Peacock |
| (8) Vanderbilt @ South Carolina | 1:00 PM | ESPNU |
| (3) Tennessee @ (9) Arkansas | 2:00 PM | ESPN2 |
| (7) Ole Miss @ Oklahoma | 2:30 PM | SEC Network |
(4) Arizona @  Utah | 3:00 PM | Peacock |
| LSU @ (9) Texas A&M | 3:00 PM | ESPNU |
January 4
| Loyola-Marymount @ (1) Gonzaga | 0:00 | |
| Seattle University @ (10) Saint Mary's College | 0:00 | |
| (11) Creighton @ Seton Hall | 0:00 | |
| Washington @ (NFO) Indiana | 0:00 | |
 Jacksonville State @ (12) Liberty | 0:00 | |
| (10) Marquette @ (1) Connecticut | 1:00 PM |
January 5
| (11) Oregon @ Rutgers | 0:00 | |
| (NFO) Nebraska @ (7) Ohio State | 5:30 PM | FS1 |
| (12) Yale @ Brown | 6:00 PM | |
 Stephen F. Austin @ (12) McNeese | 6:30 PM | |
| (8) USC @ (6) Michigan State | 7:30 PM |
January 6
| (11) Texas @ (3) Tennessee | 0:00 | |
| (4) Saint John's @ Butler | 0:00 | |
| (5) San Diego State @ Nevada | 0:00 | |
| (6) Alabama @ (8) Vanderbilt | 0:00 | |
| (7) Utah State @ Air Force | 0:00 | |
| (FFO) SMU @ (8) Clemson | 0:00 | |
 Grand Canyon @ (11) Boise State | 0:00 | |
| (FFO) Iowa @ Minnesota | 0:00 | |
| (FFO) Georgia @ (1) Florida | 6:00 PM | SEC Network |
| (2) Duke @ (4) Louisville | 6:00 PM | ESPN |
| (3) Michigan @ Penn State | 6:00 PM | FS1 |
| (10) Cincinnati @ West Virginia | 6:00 PM | ESPN2 |
| George Washington @ (11) Dayton | 7:00 PM | |
| (4) Texas Tech @ (1) Houston | 8:00 PM | FS1 |
| (3) UCLA @ (6) Wisconsin | 8:00 PM | |
| TCU @ (5) Kansas | 8:00 PM | |
| (9) Texas A&M @ (6) Auburn | 8:00 PM | SEC Network |
(FFO) North Carolina State @  Boston College | 8:00 PM | ACC Network |
January 7
| Washington @ (2) Purdue | 0:00 | |
| (NFO) Indiana @ (9) Maryland | 0:00 | |
| Xavier @ (10) Marquette | 0:00 | |
 Saint Louis @ (11) VCU | 0:00 | |
| (11) Creighton @ (NFO) Villanova | 0:00 | |
| (1) Connecticut @ Providence | 6:00 PM | |
| (8) Missouri @ (2) Kentucky | 6:00 PM | ESPN2 |
| Oklahoma @ (7) Mississippi State | 6:00 PM | SEC Network |
| Gardner-Webb @ (12) High Point | 6:00 PM | |
| (3) Iowa State @ (5) Baylor | 7:00 PM | Peacock |
| Kansas State @ (4) Arizona | 8:00 PM | FS1 |
| Arizona State @ (5) BYU | 8:00 PM | Peacock |
| (9) Arkansas @ (7) Ole Miss | 8:00 PM | SEC Network |
January 8
| Santa Clara @ (1) Gonzaga | 0:00 | |
| Rutgers @ (2) Illinois | 0:00 | |
| Northwestern @ (6) Michigan State | 0:00 | |
| (7) Ohio State @ (11) Oregon | 0:00 | |
(12) Liberty @  Louisiana Tech | 0:00 |
January 9
| (8) USC @ Minnesota | 7:30 PM |
January 10
| (3) Tennessee @ (1) Florida | 0:00 | |
| (6) Wisconsin @ (3) Michigan | 0:00 | |
| (4) Saint John's @ (11) Creighton | 0:00 | |
| Boston College @ (4) Louisville | 0:00 | |
| Fresno State @ (5) San Diego State | 0:00 | |
| (9) Arkansas @ (6) Auburn | 0:00 | |
| (7) Utah State @ (11) Boise State | 0:00 | |
| Washington State @ (10) Saint Mary's College | 0:00 | |
| (NFO) Villanova @ (10) Marquette | 0:00 | |
| (12) Yale @ Princeton | 0:00 | |
| (12) Liberty @ Sam Houston State | 0:00 | |
| (5) Kansas @ West Virginia | 11:00 AM | |
(11) VCU @  George Mason | 11:00 AM | |
| (FFO) North Carolina State @ Florida State | 11:00 AM | ACC Network |
| (NFO) Nebraska @ (NFO) Indiana | 11:00 AM | BTN |
| DePaul @ (1) Connecticut | 11:30 AM | |
| (1) Houston @ (5) Baylor | 12:00 PM | Peacock |
| LSU @ (8) Vanderbilt | 12:00 PM | SEC Network |
| (FFO) SMU @ (2) Duke | 1:00 PM | ESPN |
| Penn State @ (2) Purdue | 1:00 PM | BTN |
| Syracuse @ (NFO) Pittsburgh | 1:00 PM | ACC Network |
(12) High Point @  Charleston Southern | 1:00 PM |
January 11
| (2) Illinois @ (FFO) Iowa | 0:00 | |
| (7) Ohio State @ Washington | 0:00 | |
| (10) Memphis @ FAU | 0:00 | |
| (10) Cincinnati @ UCF | 4:00 PM | ESPN2 |
January 12
| Nicholls @ (12) McNeese | 6:30 PM |
January 13
| (1) Gonzaga @ Washington State | 0:00 | |
| (1) Florida @ Oklahoma | 0:00 | |
| (10) Marquette @ (4) Saint John's | 0:00 | |
| Virginia @ (4) Louisville | 0:00 | |
| (NFO) Indiana @ (6) Michigan State | 0:00 | |
| (6) Wisconsin @ Minnesota | 0:00 | |
| (6) Auburn @ (8) Missouri | 0:00 | |
| (7) Ole Miss @ (FFO) Georgia | 0:00 | |
| (8) Vanderbilt @ (11) Texas | 0:00 | |
| (10) Saint Mary's College @ San Francisco | 0:00 | |
| (11) Dayton @ Duquesne | 0:00 | |
| Georgetown @ (11) Creighton | 0:00 | |
| (11) Boise State @ UNLV | 0:00 | |
 Virginia Tech @ (FFO) SMU | 0:00 | |
| (NFO) Villanova @ Providence | 0:00 | |
| (9) Texas A&M @ (3) Tennessee | 6:00 PM | SEC Network |
| Boston College @ (8) Clemson | 6:00 PM | ACC Network |
| (1) Connecticut @ Seton Hall | 7:00 PM | |
| West Virginia @ (1) Houston | 7:30 PM | FS1 |
| (3) Iowa State @ (5) Kansas | 8:00 PM | |
| (5) Baylor @ Oklahoma State | 8:00 PM | CBSSN |
| (6) Alabama @ (7) Mississippi State | 8:00 PM | SEC Network |
| (11) Oregon @ (NFO) Nebraska | 8:00 PM | BTN |
| (9) Maryland @ (8) USC | 9:30 PM |
January 14
| (FFO) Iowa @ (2) Purdue | 0:00 | |
| (2) Illinois @ Northwestern | 0:00 | |
| (3) Michigan @ Washington | 0:00 | |
| (5) San Diego State @ Wyoming | 0:00 | |
| Nevada @ (7) Utah State | 0:00 | |
| Temple @ (10) Memphis | 0:00 | |
| (11) VCU @ Rhode Island | 0:00 | |
| (12) High Point @ Winthrop | 0:00 | |
| (2) Kentucky @ LSU | 6:00 PM | SEC Network |
 Colorado @ (10) Cincinnati | 6:00 PM | Peacock |
| (NFO) Pittsburgh @ Georgia Tech | 6:00 PM | ACC Network |
| (3) UCLA @ Penn State | 7:30 PM | FS1 |
| Utah @ (4) Texas Tech | 8:00 PM | Peacock |
| South Carolina @ (9) Arkansas | 8:00 PM | SEC Network |
| (9) North Carolina @ Stanford | 8:00 PM | ACC Network |
| Arizona State @ (4) Arizona | 9:30 PM | FS1 |
| (2) Duke @ California | 10:00 PM | ACC Network |
| TCU @ (5) BYU | 10:00 PM | ESPN2 |
January 15
 New Mexico State @ (12) Liberty | 0:00 |
January 16
| (10) Marquette @ DePaul | 0:00 | |
| Loyola-Chicago @ (11) Dayton | 0:00 | |
| (11) Creighton @ Providence | 0:00 | |
| (5) Baylor @ (5) Kansas | 7:00 PM | FOX |
| Colorado State @ (11) Boise State | 9:30 PM |
January 17
| (1) Gonzaga @ Seattle University | 0:00 | |
| (1) Florida @ (8) Vanderbilt | 0:00 | |
| Minnesota @ (2) Illinois | 0:00 | |
| (3) Michigan @ (11) Oregon | 0:00 | |
| (4) Saint John's @ (NFO) Villanova | 0:00 | |
| (4) Louisville @ (NFO) Pittsburgh | 0:00 | |
| New Mexico @ (5) San Diego State | 0:00 | |
| (6) Michigan State @ Washington | 0:00 | |
| Rutgers @ (6) Wisconsin | 0:00 | |
| (7) Utah State @ Grand Canyon | 0:00 | |
| (9) Texas A&M @ (11) Texas | 0:00 | |
| (9) Arkansas @ (FFO) Georgia | 0:00 | |
| (10) Saint Mary's College @ Santa Clara | 0:00 | |
| Georgia Tech @ (FFO) North Carolina State | 0:00 | |
| Virginia @ (FFO) SMU | 0:00 | |
| (FFO) Iowa @ (NFO) Indiana | 0:00 | |
| (12) McNeese @ UTRGV | 0:00 | |
| UTEP @ (12) Liberty | 0:00 | |
| (1) Connecticut @ Georgetown | 11:00 AM | |
| (2) Kentucky @ (3) Tennessee | 11:00 AM | ESPN |
| (3) UCLA @ (7) Ohio State | 12:00 PM | |
| (6) Alabama @ Oklahoma | 12:00 PM | SEC Network |
| (3) Iowa State @ (10) Cincinnati | 1:00 PM | Peacock |
January 18
| Arizona State @ (1) Houston | 0:00 | |
| UTSA @ (10) Memphis | 0:00 | |
| Penn State @ (9) Maryland | 11:00 AM | BTN |
| (5) Kansas @ Colorado | 10:00 PM | ESPN |
January 19
| Providence @ (10) Marquette | 0:00 | |
 Saint Joseph's @ (11) VCU | 0:00 | |
| Columbia @ (12) Yale | 1:00 PM | |
| (12) McNeese @ Texas A&M-Corpus Christi | 7:00 PM |
January 20
| Pepperdine @ (1) Gonzaga | 0:00 | |
| (NFO) Indiana @ (3) Michigan | 0:00 | |
| Seton Hall @ (4) Saint John's | 0:00 | |
| (6) Michigan State @ (11) Oregon | 0:00 | |
| (6) Auburn @ (7) Ole Miss | 0:00 | |
| Minnesota @ (7) Ohio State | 0:00 | |
| UNLV @ (7) Utah State | 0:00 | |
| (8) Vanderbilt @ (9) Arkansas | 0:00 | |
| Oregon State @ (10) Saint Mary's College | 0:00 | |
| (11) Boise State @ Wyoming | 0:00 | |
| Rutgers @ (FFO) Iowa | 0:00 | |
| LSU @ (1) Florida | 6:00 PM | ESPN2 |
| UCF @ (3) Iowa State | 6:00 PM | CBSSN |
| (FFO) North Carolina State @ (8) Clemson | 6:00 PM | ACC Network |
| (4) Texas Tech @ (5) Baylor | 8:00 PM | Peacock |
| (FFO) Georgia @ (8) Missouri | 8:00 PM | SEC Network |
| (FFO) SMU @ Wake Forest | 8:00 PM | ACC Network |
| (2) Purdue @ (3) UCLA | 9:00 PM |
January 21
| (9) Maryland @ (2) Illinois | 0:00 | |
| (5) San Diego State @ Grand Canyon | 0:00 | |
(10) Memphis @  Tulsa | 0:00 | |
| (11) Dayton @ La Salle | 0:00 | |
| Xavier @ (11) Creighton | 0:00 | |
| Georgetown @ (NFO) Villanova | 0:00 | |
| (12) Liberty @ Western Kentucky | 0:00 | |
| (11) Texas @ (2) Kentucky | 6:00 PM | SEC Network |
| Notre Dame @ (9) North Carolina | 6:00 PM | ESPN2 |
| (NFO) Pittsburgh @ Boston College | 6:00 PM | ACC Network |
| (10) Cincinnati @ (4) Arizona | 8:00 PM | FS1 |
| (7) Mississippi State @ (9) Texas A&M | 8:00 PM | SEC Network |
| Washington @ (NFO) Nebraska | 8:00 PM | BTN |
| Northwestern @ (8) USC | 10:00 PM |
January 22
| (6) Wisconsin @ Penn State | 6:00 PM | FS1 |
| (6) Wisconsin @ Penn State | 6:00 PM | FS1 |
January 23
| (7) Ohio State @ (3) Michigan | 0:00 | |
| (10) Marquette @ Butler | 0:00 | |
| (NFO) Indiana @ Rutgers | 0:00 | |
| (7) Utah State @ Colorado State | 9:00 PM |
January 24
| San Francisco @ (1) Gonzaga | 0:00 | |
| (6) Auburn @ (1) Florida | 0:00 | |
| Wake Forest @ (2) Duke | 0:00 | |
| (2) Illinois @ (2) Purdue | 0:00 | |
| (4) Saint John's @ Xavier | 0:00 | |
| Virginia Tech @ (4) Louisville | 0:00 | |
| (5) San Diego State @ UNLV | 0:00 | |
| (9) Maryland @ (6) Michigan State | 0:00 | |
| Oklahoma @ (8) Missouri | 0:00 | |
| (9) North Carolina @ Virginia | 0:00 | |
| (10) Saint Mary's College @ Portland | 0:00 | |
| (10) Memphis @ Wichita State | 0:00 | |
| (11) Dayton @ Saint Joseph's | 0:00 | |
| (11) VCU @ Davidson | 0:00 | |
| Air Force @ (11) Boise State | 0:00 | |
| (FFO) North Carolina State @ (NFO) Pittsburgh | 0:00 | |
| Delaware @ (12) Liberty | 0:00 | |
| (12) High Point @ Radford | 0:00 | |
| (7) Ole Miss @ (2) Kentucky | 11:00 AM | ESPN |
| (8) Clemson @ Georgia Tech | 11:00 AM | ACC Network |
| (NFO) Nebraska @ Minnesota | 11:00 AM | FS1 |
| (NFO) Villanova @ (1) Connecticut | 11:30 AM | |
| (FFO) Georgia @ (11) Texas | 12:00 PM | SEC Network |
| West Virginia @ (4) Arizona | 1:00 PM | CBS |
January 26
| (12) McNeese @ Southeastern Louisiana | 0:00 | |
| (4) Louisville @ (2) Duke | 6:00 PM | ESPN |
| Penn State @ (7) Ohio State | 6:00 PM | FS1 |
| (4) Arizona @ (5) BYU | 8:00 PM | ESPN |
January 27
| (2) Purdue @ (NFO) Indiana | 0:00 | |
| (6) Michigan State @ Rutgers | 0:00 | |
| (9) Arkansas @ Oklahoma | 0:00 | |
| (11) Creighton @ (10) Marquette | 0:00 | |
| Rhode Island @ (11) Dayton | 0:00 | |
 Richmond @ (11) VCU | 0:00 | |
| (11) Boise State @ San Jose State | 0:00 | |
| Syracuse @ (FFO) North Carolina State | 0:00 | |
| Wake Forest @ (NFO) Pittsburgh | 5:00 PM | ACC Network |
| (3) Tennessee @ (FFO) Georgia | 6:00 PM | SEC Network |
| (NFO) Nebraska @ (3) Michigan | 6:00 PM | Peacock |
| Providence @ (1) Connecticut | 6:30 PM | |
| (2) Kentucky @ (8) Vanderbilt | 8:00 PM | ESPN |
| (8) Missouri @ (6) Alabama | 8:00 PM | SEC Network |
January 28
| Butler @ (4) Saint John's | 0:00 | |
| Minnesota @ (6) Wisconsin | 0:00 | |
| Wyoming @ (7) Utah State | 0:00 | |
| (12) Liberty @ Middle Tennessee | 0:00 | |
| (5) Baylor @ (10) Cincinnati | 5:30 PM | FS1 |
| (11) Texas @ (6) Auburn | 6:00 PM | ESPN2 |
| (7) Mississippi State @ LSU | 6:00 PM | SEC Network |
| (8) USC @ (FFO) Iowa | 6:00 PM | |
| (1) Houston @ TCU | 8:00 PM | ESPN2 |
| (1) Florida @ South Carolina | 8:00 PM | SEC Network |
| Colorado State @ (5) San Diego State | 9:30 PM | |
| (3) UCLA @ (11) Oregon | 10:00 PM |
January 29
| Washington @ (2) Illinois | 0:00 | |
| FAU @ (10) Memphis | 0:00 | |
| Colorado @ (3) Iowa State | 6:00 PM | FS1 |
| Presbyterian College @ (12) High Point | 6:00 PM |
January 30
| (3) Michigan @ (6) Michigan State | 0:00 | |
| (11) Dayton @ Saint Louis | 0:00 | |
| Loyola-Chicago @ (11) VCU | 0:00 | |
| (11) Boise State @ Grand Canyon | 0:00 | |
| Providence @ (NFO) Villanova | 0:00 | |
| Dartmouth @ (12) Yale | 6:00 PM |
January 31
| (10) Saint Mary's College @ (1) Gonzaga | 0:00 | |
| (FFO) SMU @ (4) Louisville | 0:00 | |
| (5) BYU @ (5) Kansas | 0:00 | ESPN |
| (5) San Diego State @ (7) Utah State | 0:00 | |
| (7) Ohio State @ (6) Wisconsin | 0:00 | |
| (10) Marquette @ Seton Hall | 0:00 | |
| (11) Texas @ Oklahoma | 0:00 | |
| (FFO) North Carolina State @ Wake Forest | 0:00 | |
| (12) High Point @ Longwood | 0:00 | |
| (10) Cincinnati @ (1) Houston | 11:00 AM | FOX |
| (2) Duke @ Virginia Tech | 11:00 AM | ESPN |
| (4) Texas Tech @ UCF | 11:00 AM | ESPN2 |
| (NFO) Pittsburgh @ (8) Clemson | 11:00 AM | ACC Network |
| (9) Texas A&M @ (FFO) Georgia | 12:00 PM | SEC Network |
| (9) North Carolina @ Georgia Tech | 1:00 PM | ACC Network |
February 1
| (2) Purdue @ (9) Maryland | 0:00 | |
| Tulane @ (10) Memphis | 0:00 | |
| (FFO) Iowa @ (11) Oregon | 0:00 | |
| (6) Alabama @ (1) Florida | 12:00 PM | ABC |
| (3) Iowa State @ Kansas State | 1:00 PM | FOX |
| (2) Illinois @ (NFO) Nebraska | 3:00 PM | FS1 |
February 2
| Syracuse @ (9) North Carolina | 6:00 PM | ESPN |
| (12) McNeese @ Stephen F. Austin | 6:00 PM | |
| (5) Kansas @ (4) Texas Tech | 8:00 PM | ESPN |
February 3
| (1) Gonzaga @ Portland | 0:00 | |
| (4) Saint John's @ DePaul | 0:00 | |
| Wyoming @ (5) San Diego State | 0:00 | |
| (7) Utah State @ New Mexico | 0:00 | |
| San Diego @ (10) Saint Mary's College | 0:00 | |
| Saint Bonaventure @ (11) Dayton | 0:00 | |
| Nevada @ (11) Boise State | 0:00 | |
| (FFO) North Carolina State @ (FFO) SMU | 0:00 | |
| Xavier @ (1) Connecticut | 6:00 PM | |
| Boston College @ (2) Duke | 6:00 PM | ACC Network |
| (7) Ole Miss @ (3) Tennessee | 6:00 PM | ESPN2 |
| South Carolina @ (11) Texas | 6:00 PM | SEC Network |
| (11) VCU @ Fordham | 6:00 PM | |
| (NFO) Pittsburgh @ Virginia | 8:00 PM | ACC Network |
| Rutgers @ (3) UCLA | 8:30 PM | |
| (NFO) Indiana @ (8) USC | 9:00 PM |
February 4
| Northwestern @ (2) Illinois | 0:00 | |
| (6) Michigan State @ Minnesota | 0:00 | |
| (11) Creighton @ Georgetown | 0:00 | |
| (FFO) Iowa @ Washington | 0:00 | |
| Seton Hall @ (NFO) Villanova | 0:00 | |
| (12) Liberty @ Delaware | 0:00 | |
| UCF @ (1) Houston | 6:00 PM | FS1 |
| Oklahoma @ (2) Kentucky | 6:00 PM | ESPN2 |
| Notre Dame @ (4) Louisville | 6:00 PM | ESPN2 |
| (9) Texas A&M @ (6) Alabama | 6:00 PM | SEC Network |
| Charleston Southern @ (12) High Point | 6:00 PM | |
| Colorado @ (5) Baylor | 7:00 PM | Peacock |
| (5) BYU @ Oklahoma State | 8:00 PM | FS1 |
| (8) Clemson @ Stanford | 9:00 PM | ACC Network |
February 5
| (7) Ohio State @ (9) Maryland | 0:00 | |
| (10) Memphis @ UAB | 0:00 | |
| Penn State @ (3) Michigan | 5:30 PM | FS1 |
| West Virginia @ (10) Cincinnati | 6:00 PM | ESPN2 |
February 6
| (11) Dayton @ (11) VCU | 0:00 | |
| Brown @ (12) Yale | 6:00 PM | |
| (1) Connecticut @ (4) Saint John's | 7:00 PM |
February 7
| (1) Gonzaga @ Oregon State | 0:00 | |
| (11) Oregon @ (2) Purdue | 0:00 | |
| (5) San Diego State @ Air Force | 0:00 | |
| (6) Alabama @ (6) Auburn | 0:00 | |
| (6) Wisconsin @ (NFO) Indiana | 0:00 | |
| (9) Arkansas @ (7) Mississippi State | 0:00 | |
| (7) Ole Miss @ (11) Texas | 0:00 | |
| (7) Utah State @ Wyoming | 0:00 | |
| San Francisco @ (10) Saint Mary's College | 0:00 | |
| Butler @ (10) Marquette | 0:00 | |
| Seton Hall @ (11) Creighton | 0:00 | |
| (11) Boise State @ New Mexico | 0:00 | |
| Virginia Tech @ (FFO) North Carolina State | 0:00 | |
| (FFO) SMU @ (NFO) Pittsburgh | 0:00 | |
| (NFO) Villanova @ Georgetown | 0:00 | |
 Missouri State @ (12) Liberty | 0:00 | |
| (4) Louisville @ Wake Forest | 11:00 AM | ACC Network |
| (NFO) Nebraska @ Rutgers | 11:00 AM | BTN |
| (8) Missouri @ South Carolina | 12:00 PM | SEC Network |
| (5) Baylor @ (3) Iowa State | 1:00 PM |
February 8
| (3) Michigan @ (7) Ohio State | 0:00 | |
| (9) Maryland @ Minnesota | 0:00 | |
| Charlotte @ (10) Memphis | 0:00 | |
| Northwestern @ (FFO) Iowa | 0:00 | |
| (8) USC @ Penn State | 11:00 AM | BTN |
| (4) Texas Tech @ West Virginia | 12:00 PM | FOX |
| UCF @ (10) Cincinnati | 1:00 PM | CBSSN |
February 9
| Xavier @ (4) Saint John's | 0:00 | |
| (11) Oregon @ (NFO) Indiana | 0:00 | |
| (12) Yale @ Howard | 0:00 | |
| (FFO) North Carolina State @ (4) Louisville | 6:00 PM | ESPN |
| Houston Christian @ (12) McNeese | 6:30 PM | |
| (4) Arizona @ (5) Kansas | 8:00 PM | ESPN |
February 10
| Washington State @ (1) Gonzaga | 0:00 | |
| (1) Florida @ (FFO) Georgia | 0:00 | |
| (2) Duke @ (NFO) Pittsburgh | 0:00 | |
| (6) Wisconsin @ (2) Illinois | 0:00 | |
| Fresno State @ (7) Utah State | 0:00 | |
| Pepperdine @ (10) Saint Mary's College | 0:00 | |
| (10) Marquette @ (NFO) Villanova | 0:00 | |
| (2) Purdue @ (NFO) Nebraska | 6:00 PM | FS1 |
| (5) BYU @ (5) Baylor | 6:00 PM | |
| (8) Vanderbilt @ (6) Auburn | 6:00 PM | SEC Network |
| (9) North Carolina @ Miami (FL) | 6:00 PM | |
| Notre Dame @ (FFO) SMU | 6:00 PM | ACC Network |
| (1) Houston @ Utah | 8:00 PM | |
| (3) Iowa State @ TCU | 8:00 PM | FS1 |
| (9) Arkansas @ LSU | 8:00 PM | SEC Network |
February 11
| (3) Tennessee @ (7) Mississippi State | 0:00 | |
| (3) Michigan @ Northwestern | 0:00 | |
| (FFO) Iowa @ (9) Maryland | 0:00 | |
| (10) Cincinnati @ Kansas State | 0:00 | CBSSN |
| (11) Creighton @ DePaul | 0:00 | |
| (12) Liberty @ New Mexico State | 0:00 | |
| (11) VCU @ La Salle | 5:30 PM | |
| (6) Alabama @ (7) Ole Miss | 6:00 PM | SEC Network |
| Virginia Tech @ (8) Clemson | 6:00 PM | ACC Network |
| (1) Connecticut @ Butler | 6:30 PM | |
| (8) USC @ (7) Ohio State | 6:30 PM | |
| Colorado @ (4) Texas Tech | 7:00 PM | ESPN+ |
| (8) Missouri @ (9) Texas A&M | 8:00 PM | SEC Network |
February 12
| (10) Memphis @ North Texas | 0:00 | |
| (12) High Point @ South Carolina Upstate | 6:00 PM |
February 13
| (6) Michigan State @ (6) Wisconsin | 0:00 | |
| UNLV @ (11) Boise State | 0:00 | |
| (12) Yale @ Dartmouth | 6:00 PM |
February 14
| (1) Gonzaga @ Santa Clara | 0:00 | |
| (2) Purdue @ (FFO) Iowa | 0:00 | |
| (4) Texas Tech @ (4) Arizona | 0:00 | |
| (4) Saint John's @ Providence | 0:00 | |
| Nevada @ (5) San Diego State | 0:00 | |
| (6) Auburn @ (9) Arkansas | 0:00 | |
| (7) Mississippi State @ (7) Ole Miss | 0:00 | |
| (7) Ohio State v. Virginia | 0:00 | |
| (10) Memphis @ (7) Utah State | 0:00 | |
| (11) Texas @ (8) Missouri | 0:00 | |
| (10) Saint Mary's College @ Pacific | 0:00 | |
| (10) Marquette @ Xavier | 0:00 | |
| (11) VCU @ Richmond | 0:00 | |
| (NFO) Villanova @ (11) Creighton | 0:00 | |
| (FFO) SMU @ Syracuse | 0:00 | |
| (12) Liberty @ UTEP | 0:00 | |
| (8) Clemson @ (2) Duke | 11:00 AM | ESPN |
| (3) UCLA @ (3) Michigan | 12:00 PM | |
| (5) Kansas @ (3) Iowa State | 12:00 PM | ABC |
| (9) Texas A&M @ (8) Vanderbilt | 12:00 PM | SEC Network |
| Northwestern @ (NFO) Nebraska | 12:00 PM | BTN |
| (NFO) Pittsburgh @ (9) North Carolina | 1:00 PM | ESPN |
| (12) High Point @ Gardner-Webb | 1:00 PM | |
| (2) Kentucky @ (1) Florida | 2:00 PM | ABC |
February 15
| (NFO) Indiana @ (2) Illinois | 0:00 | |
| (9) Maryland @ Rutgers | 0:00 | |
| Davidson @ (11) Dayton | 0:00 | |
| Utah @ (10) Cincinnati | 11:00 AM |
February 16
| Syracuse @ (2) Duke | 6:00 PM | ESPN |
| (12) McNeese @ Northwestern State | 6:30 PM | |
| (1) Houston @ (3) Iowa State | 8:00 PM | ESPN |
February 17
| (3) Michigan @ (2) Purdue | 0:00 | |
| Oklahoma @ (3) Tennessee | 0:00 | |
| (4) Louisville @ (FFO) SMU | 0:00 | |
| Grand Canyon @ (5) San Diego State | 0:00 | |
| (9) Arkansas @ (6) Alabama | 0:00 | |
| (6) Wisconsin @ (7) Ohio State | 0:00 | |
| (11) Boise State @ (7) Utah State | 0:00 | |
| (9) North Carolina @ (FFO) North Carolina State | 0:00 | |
| (10) Saint Mary's College @ Seattle University | 0:00 | |
| Minnesota @ (11) Oregon | 0:00 | |
| George Washington @ (11) VCU | 0:00 | |
| (NFO) Villanova @ Xavier | 0:00 | |
| South Carolina @ (1) Florida | 6:00 PM | SEC Network |
| (3) UCLA @ (6) Michigan State | 7:30 PM | |
| (FFO) Georgia @ (2) Kentucky | 8:00 PM | |
| (5) Baylor @ Kansas State | 8:00 PM | |
| LSU @ (11) Texas | 8:00 PM | SEC Network |
| (NFO) Nebraska @ (FFO) Iowa | 8:00 PM | BTN |
| (4) Texas Tech @ Arizona State | 10:00 PM |
February 18
| (1) Gonzaga @ San Francisco | 0:00 | |
| (4) Saint John's @ (10) Marquette | 0:00 | |
| (9) Maryland @ Northwestern | 0:00 | |
| (11) Creighton @ (1) Connecticut | 6:00 PM | |
| (7) Ole Miss @ (9) Texas A&M | 6:00 PM | SEC Network |
| (8) Clemson @ Wake Forest | 6:00 PM | ACC Network |
| (11) Dayton @ George Mason | 6:00 PM | |
| (5) BYU @ (4) Arizona | 8:00 PM | ESPN |
| (5) Kansas @ Oklahoma State | 8:00 PM | Peacock |
| (6) Auburn @ (7) Mississippi State | 8:00 PM | ESPN2 |
| (8) Vanderbilt @ (8) Missouri | 8:00 PM | SEC Network |
| (2) Illinois @ (8) USC | 9:00 PM |
February 19
| (10) Memphis @ South Florida | 0:00 | |
| FIU @ (12) Liberty | 0:00 | |
| UNC Asheville @ (12) High Point | 6:00 PM |
February 20
| (NFO) Indiana @ (2) Purdue | 0:00 | |
| (11) VCU @ Saint Louis | 0:00 |
February 21
| Pacific @ (1) Gonzaga | 0:00 | |
| (1) Florida @ (7) Ole Miss | 0:00 | |
| (2) Duke v. (3) Michigan | 0:00 | |
| (3) Tennessee @ (8) Vanderbilt | 0:00 | |
| (11) Creighton @ (4) Saint John's | 0:00 | |
| Georgia Tech @ (4) Louisville | 0:00 | |
| (5) San Diego State @ Colorado State | 0:00 | |
| (7) Utah State @ Nevada | 0:00 | |
| Florida State @ (8) Clemson | 0:00 | |
| (8) Missouri @ (9) Arkansas | 0:00 | |
| Washington @ (9) Maryland | 0:00 | |
| (10) Saint Mary's College @ Washington State | 0:00 | |
| Duquesne @ (11) Dayton | 0:00 | |
| San Jose State @ (11) Boise State | 0:00 | |
| Western Kentucky @ (12) Liberty | 0:00 | |
| (10) Cincinnati @ (5) Kansas | 12:00 PM | CBS |
| (7) Mississippi State @ South Carolina | 12:00 PM | SEC Network |
| (9) North Carolina @ Syracuse | 12:00 PM | ABC |
| Penn State @ (NFO) Nebraska | 1:00 PM | BTN |
February 22
| (7) Ohio State @ (6) Michigan State | 0:00 | |
| (7) Ohio State @ (6) Michigan State | 0:00 | |
| (FFO) Iowa @ (6) Wisconsin | 0:00 | |
| (FFO) Iowa @ (6) Wisconsin | 0:00 | |
| UAB @ (10) Memphis | 0:00 | |
| UAB @ (10) Memphis | 0:00 |
February 23
| (4) Louisville @ (9) North Carolina | 6:00 PM | ESPN |
| UTRGV @ (12) McNeese | 6:30 PM | |
| (1) Houston @ (5) Kansas | 8:00 PM | ESPN |
February 24
| Portland @ (1) Gonzaga | 0:00 | |
| (2) Duke @ Notre Dame | 0:00 | |
| Minnesota @ (3) Michigan | 0:00 | |
| (7) Utah State @ (5) San Diego State | 0:00 | |
| (7) Mississippi State @ (6) Alabama | 0:00 | |
| (6) Auburn @ Oklahoma | 0:00 | |
| (9) Texas A&M @ (9) Arkansas | 0:00 | |
| Santa Clara @ (10) Saint Mary's College | 0:00 | |
| (10) Marquette @ Georgetown | 0:00 | |
| Saint Louis @ (11) Dayton | 0:00 | |
| Wyoming @ (11) Boise State | 0:00 | |
| Northwestern @ (NFO) Indiana | 0:00 | |
| (2) Kentucky @ South Carolina | 6:00 PM | SEC Network |
| (10) Cincinnati @ (4) Texas Tech | 6:00 PM | |
| (FFO) North Carolina State @ Virginia | 6:00 PM | ACC Network |
| (3) Tennessee @ (8) Missouri | 8:00 PM | SEC Network |
| (3) Iowa State @ Utah | 8:00 PM | FS1 |
| (4) Arizona @ (5) Baylor | 8:00 PM | ESPN2 |
| (8) USC @ (3) UCLA | 10:00 PM | |
| UCF @ (5) BYU | 10:00 PM |
February 26
| (6) Michigan State @ (2) Purdue | 0:00 | |
| Wichita State @ (10) Memphis | 0:00 | |
| (12) Liberty @ Kennesaw State | 0:00 | |
| (12) High Point @ Presbyterian College | 0:00 |
February 27
| (3) Michigan @ (2) Illinois | 0:00 | |
| (12) Yale @ Cornell | 5:00 PM | |
| (11) Dayton @ George Washington | 6:00 PM |
February 28
| (1) Gonzaga @ (10) Saint Mary's College | 0:00 | |
| (9) Arkansas @ (1) Florida | 0:00 | |
| Virginia @ (2) Duke | 0:00 | |
| (6) Alabama @ (3) Tennessee | 0:00 | |
| (NFO) Villanova @ (4) Saint John's | 0:00 | |
| (5) Kansas @ (4) Arizona | 0:00 | ESPN |
| (4) Louisville @ (8) Clemson | 0:00 | |
| (5) San Diego State @ New Mexico | 0:00 | |
| (6) Wisconsin @ Washington | 0:00 | |
| Grand Canyon @ (7) Utah State | 0:00 | |
| (11) Texas @ (9) Texas A&M | 0:00 | |
| Virginia Tech @ (9) North Carolina | 0:00 | |
| (11) Oregon @ Northwestern | 0:00 | |
| Providence @ (11) Creighton | 0:00 | |
| (11) Boise State @ Fresno State | 0:00 | |
| (FFO) North Carolina State @ Notre Dame | 0:00 | |
| (12) McNeese @ New Orleans | 0:00 | |
| Colorado @ (1) Houston | 11:00 AM | |
| Seton Hall @ (1) Connecticut | 11:00 AM | |
| (FFO) Iowa @ Penn State | 11:00 AM | BTN |
| Fordham @ (11) VCU | 11:30 AM | |
| (8) Missouri @ (7) Mississippi State | 12:00 PM | SEC Network |
| (8) Vanderbilt @ (2) Kentucky | 1:00 PM | |
| (3) UCLA @ Minnesota | 1:00 PM | |
| Oklahoma State @ (10) Cincinnati | 1:00 PM | CBSSN |
March 1
| (2) Purdue @ (7) Ohio State | 0:00 | |
| (6) Michigan State @ (NFO) Indiana | 0:00 | |
| Rutgers @ (9) Maryland | 0:00 | |
| (10) Memphis @ East Carolina | 0:00 | |
| DePaul @ (10) Marquette | 0:00 |
March 2
| (12) McNeese @ Nicholls | 0:00 | |
| (2) Duke @ (FFO) North Carolina State | 6:00 PM | ESPN |
| (3) Iowa State @ (4) Arizona | 8:00 PM | ESPN |
March 3
| (11) Oregon @ (2) Illinois | 0:00 | |
| Georgetown @ (4) Saint John's | 0:00 | |
| (5) San Diego State @ (11) Boise State | 0:00 | |
| (7) Utah State @ UNLV | 0:00 | |
| (8) Clemson @ (9) North Carolina | 0:00 | |
| (11) Texas @ (9) Arkansas | 0:00 | |
| (11) Dayton @ Richmond | 0:00 | |
| George Mason @ (11) VCU | 0:00 | |
| (3) Tennessee @ South Carolina | 5:00 PM | SEC Network |
| (6) Alabama @ (FFO) Georgia | 5:30 PM | ESPNEWS |
| (2) Kentucky @ (9) Texas A&M | 6:00 PM | |
| TCU @ (4) Texas Tech | 6:00 PM | FS1 |
| (5) BYU @ (10) Cincinnati | 6:00 PM | |
| (8) Missouri @ Oklahoma | 6:00 PM | ESPNU |
| (7) Mississippi State @ (1) Florida | 7:00 PM | SEC Network |
| Syracuse @ (4) Louisville | 8:00 PM | ACC Network |
| (5) Kansas @ Arizona State | 8:00 PM | FS1 |
| LSU @ (6) Auburn | 9:00 PM | SEC Network |
| (NFO) Nebraska @ (3) UCLA | 10:00 PM | FS1 |
March 4
| (2) Purdue @ Northwestern | 0:00 | |
| (9) Maryland @ (6) Wisconsin | 0:00 | |
| (10) Marquette @ Providence | 0:00 | |
| (11) Creighton @ Butler | 0:00 | |
| Minnesota @ (NFO) Indiana | 0:00 | |
| (NFO) Villanova @ DePaul | 0:00 | |
| (7) Ole Miss @ (8) Vanderbilt | 5:30 PM | ESPNEWS |
| Miami (FL) @ (FFO) SMU | 6:00 PM | ACC Network |
| (7) Ohio State @ Penn State | 6:30 PM | Peacock |
| (5) Baylor @ (1) Houston | 8:00 PM | ESPN2 |
| Florida State @ (NFO) Pittsburgh | 8:00 PM | ACC Network |
| (8) USC @ Washington | 9:30 PM |
March 5
| (3) Michigan @ (FFO) Iowa | 0:00 | |
| Rutgers @ (6) Michigan State | 0:00 | |
| South Florida @ (10) Memphis | 0:00 | |
| Louisiana Tech @ (12) Liberty | 0:00 |
March 6
| (4) Saint John's @ Seton Hall | 0:00 | |
| UNLV @ (5) San Diego State | 0:00 | |
| (11) VCU @ (11) Dayton | 0:00 |
March 7
| (6) Wisconsin @ (2) Purdue | 0:00 | |
| (8) Vanderbilt @ (3) Tennessee | 0:00 | |
| (NFO) Indiana @ (7) Ohio State | 0:00 | |
| New Mexico @ (7) Utah State | 0:00 | |
| Washington @ (11) Oregon | 0:00 | |
| (11) Boise State @ Colorado State | 0:00 | |
| Stanford @ (FFO) North Carolina State | 0:00 | |
| (NFO) Pittsburgh @ Syracuse | 0:00 | |
| Xavier @ (NFO) Villanova | 0:00 | |
| Sam Houston State @ (12) Liberty | 0:00 | |
| (1) Houston @ Oklahoma State | 11:00 AM | CBS |
| Georgia Tech @ (8) Clemson | 11:00 AM | ACC Network |
| (9) Arkansas @ (8) Missouri | 11:00 AM | ESPN |
| (1) Connecticut @ (10) Marquette | 11:30 AM | |
| South Carolina @ (7) Ole Miss | 12:00 PM | SEC Network |
| Arizona State @ (3) Iowa State | 1:00 PM | FS1 |
| (4) Louisville @ Miami (FL) | 1:00 PM | |
| Kansas State @ (5) Kansas | 1:00 PM | CBS |
| (10) Cincinnati @ TCU | 1:00 PM | TNT |
| (FFO) SMU @ Florida State | 1:00 PM | ACC Network |
| Princeton @ (12) Yale | 1:00 PM | |
| (FFO) Georgia @ (7) Mississippi State | 2:30 PM | SEC Network |
| (1) Florida @ (2) Kentucky | 3:00 PM | ESPN |
| Utah @ (5) Baylor | 4:00 PM | Peacock |
| (9) Texas A&M @ LSU | 5:00 PM | SEC Network |
| (9) North Carolina @ (2) Duke | 5:30 PM | ESPN |
| (6) Auburn @ (6) Alabama | 7:30 PM | ESPN |
| Oklahoma @ (11) Texas | 7:30 PM | SEC Network |
| (3) UCLA @ (8) USC | 8:00 PM | |
| (4) Texas Tech @ (5) BYU | 9:30 PM | ESPN |
| (4) Arizona @ Colorado | 10:00 PM | ESPN2 |
March 8
| (2) Illinois @ (9) Maryland | 0:00 | |
| (6) Michigan State @ (3) Michigan | 0:00 | |
| (10) Memphis @ Tulane | 0:00 | |
| (FFO) Iowa @ (NFO) Nebraska | 4:00 PM | FOX |