January 22
 Penn State @ (5)  Michigan State | 5:30 PM | |
(1)  USC @  Purdue | 6:00 PM | Peacock |
 Villanova @ (2)  Connecticut | 6:00 PM | SNY |
(8)  Creighton @  Butler | 6:00 PM | |
 Davidson @ (FFO)  George Mason | 6:00 PM | |
 Saint Bonaventure @ (NFO)  Saint Joseph's | 6:00 PM | |
(3)  TCU @ (7)  Oklahoma State | 6:30 PM | |
 BYU @ (9)  Iowa State | 6:30 PM | |
 Tulsa @ (12)  UTSA | 6:30 PM | |
(8)  Michigan @ (10)  Minnesota | 7:00 PM | |
(11)  South Dakota State @  Saint Thomas | 7:00 PM | |
(5)  West Virginia @  Arizona State | 7:30 PM | |
(NFO)  Kansas @ (6)  Utah | 8:00 PM | |
(10)  Iowa @ (11)  Washington | 8:00 PM | Peacock |
(12)  UNLV @  Fresno State | 8:00 PM |
January 23
 Manhattan @ (12)  Fairfield | 10:00 AM | |
(4)  Maryland @ (4)  Ohio State | 5:00 PM | BTN |
(7)  North Carolina State @  Syracuse | 5:00 PM | ACC Network |
(11)  Virginia Tech @  Pittsburgh | 5:00 PM | |
(1)  UCLA @  Rutgers | 6:00 PM | FS1 |
(2)  Notre Dame @  Boston College | 6:00 PM | |
 Wake Forest @ (3)  North Carolina | 6:00 PM | |
(5)  Georgia Tech @  Virginia | 6:00 PM | |
(6)  Kentucky @  Texas A&M | 6:00 PM | SEC Network |
(9)  Richmond @  Loyola-Chicago | 6:00 PM | |
 Southern Miss @ (11)  James Madison | 6:00 PM | |
 Arkansas @ (7)  Vanderbilt | 6:30 PM | |
(NFO)  Auburn @ (8)  Mississippi State | 6:30 PM | |
(2)  LSU @ (1)  South Carolina | 7:00 PM | ESPN |
(3)  Duke @  SMU | 7:00 PM | ACC Network |
(11)  Illinois @  Northwestern | 7:00 PM | BTN |
(3)  Tennessee @ (1)  Texas | 8:00 PM | SEC Network |
(7)  California @ (9)  Stanford | 9:00 PM |
January 24
(10)  Indiana @ (10)  Oregon | 8:00 PM |
January 25
| (5) Michigan State @ (8) Michigan | 11:00 AM | BTN |
(FFO)  Princeton @  Cornell | 12:00 PM | |
 Saint John's @ (FFO)  Seton Hall | 12:00 PM | |
 Yale @ (9)  Harvard | 1:00 PM | |
(11) South Dakota State @  South Dakota | 1:00 PM | |
 Penn @ (FFO)  Columbia | 1:00 PM | |
 Coastal Carolina @ (11) James Madison | 1:00 PM | |
(12)  Ball State @  Northern Illinois | 1:00 PM | |
 La Salle @ (NFO) Saint Joseph's | 1:00 PM | |
(2)  Kansas State @  Colorado | 2:00 PM | |
(7) Oklahoma State @  Texas Tech | 2:00 PM | |
 George Washington @ (FFO) George Mason | 2:00 PM | |
(NFO) Kansas @  Houston | 2:00 PM | |
(12) Fairfield @  Merrimack | 2:00 PM | |
(12) UNLV @  San Diego State | 3:00 PM | |
| (6) Utah @ BYU | 3:30 PM | ESPNU |
 UCF @ (9) Iowa State | 4:00 PM | |
| (2) Connecticut @ (8) Creighton | 4:30 PM | FOX |
(5) West Virginia @  Arizona | 7:30 PM |
January 26
(6)  Florida State @ (3) North Carolina | 11:00 AM | ACC Network |
| Arkansas @ (6) Kentucky | 11:00 AM | SEC Network |
(9) Richmond @  Dayton | 12:00 PM | |
| (1) UCLA @ (4) Maryland | 1:00 PM | NBC |
| (3) Duke @ (5) Georgia Tech | 1:00 PM | |
(7) Vanderbilt @ (4)  Alabama | 1:00 PM | SEC Network |
(9)  Louisville @ Virginia | 1:00 PM | |
 Georgia @ (4)  Oklahoma | 1:30 PM | |
(1) Texas @ (5)  Ole Miss | 2:00 PM | |
(6)  Baylor @ (3) TCU | 2:00 PM | ESPN2 |
(4) Ohio State @ (8)  Nebraska | 2:00 PM | |
 Wisconsin @ (10) Minnesota | 2:00 PM | |
(NFO)  Florida @ (NFO) Auburn | 2:00 PM | |
| Texas A&M @ (2) LSU | 3:00 PM | SEC Network |
| (11) Virginia Tech @ (7) North Carolina State | 5:00 PM | ACC Network |
January 27
| (1) South Carolina @ (3) Tennessee | 6:00 PM | ESPN2 |
(8) Mississippi State @  Missouri | 7:00 PM | SEC Network |
| Purdue @ (11) Illinois | 7:30 PM | BTN |
| (10) Indiana @ (11) Washington | 8:00 PM |
January 28
| Northwestern @ (10) Iowa | 7:00 PM | BTN |
January 29
(FFO) George Mason @  Saint Louis | 11:00 AM | |
| (4) Maryland @ Penn State | 5:00 PM | |
(11) James Madison @  Georgia Southern | 5:00 PM | |
(2) Connecticut @  DePaul | 6:00 PM | SNY |
| (6) Baylor @ UCF | 6:00 PM | |
(8) Creighton @  Georgetown | 6:00 PM | |
| Butler @ (FFO) Seton Hall | 6:00 PM | |
(12) Ball State @  Ohio | 6:00 PM | |
(12) UTSA @  South Florida | 6:00 PM | |
| (NFO) Saint Joseph's @ Davidson | 6:00 PM | |
| Arizona State @ (7) Oklahoma State | 6:30 PM | |
| (8) Michigan @ Wisconsin | 6:30 PM | |
| Texas Tech @ (NFO) Kansas | 6:30 PM | |
 North Dakota State @ (11) South Dakota State | 7:00 PM |
January 30
| (2) Notre Dame @ (11) Virginia Tech | 5:00 PM | |
| (5) Ole Miss @ Georgia | 5:00 PM | |
| (10) Oregon @ (5) Michigan State | 5:00 PM | BTN |
| (6) Florida State @ Boston College | 5:00 PM | ACC Network |
| (7) North Carolina State @ Wake Forest | 5:00 PM | |
| (4) Oklahoma @ (2) LSU | 6:00 PM | ESPN2 |
| (4) Alabama @ (6) Kentucky | 6:00 PM | SEC Network |
| (7) Vanderbilt @ (NFO) Florida | 6:00 PM | |
| (8) Nebraska @ Purdue | 6:00 PM | |
| (11) Illinois @ Rutgers | 6:00 PM | |
 Quinnipiac @ (12) Fairfield | 6:00 PM | |
| (9) Louisville @ SMU | 7:00 PM | ACC Network |
| (9) Iowa State @ (2) Kansas State | 7:30 PM | ESPN |
| Missouri @ (1) Texas | 8:00 PM | SEC Network |
| (10) Minnesota @ (1) USC | 9:00 PM | Peacock |
| (3) North Carolina @ (7) California | 9:00 PM | |
| Pittsburgh @ (9) Stanford | 9:00 PM |
January 31
| (FFO) Princeton @ Yale | 5:00 PM | |
| (FFO) Columbia @ (9) Harvard | 6:00 PM | ESPNU |
| Arizona @ (6) Utah | 7:30 PM | FS1 |
February 1
| (7) Oklahoma State @ (5) West Virginia | 11:00 AM | ESPNU |
| (FFO) George Mason @ Dayton | 12:00 PM | |
 Western Michigan @ (12) Ball State | 12:00 PM | |
(11) James Madison @  Old Dominion | 1:00 PM | |
| (NFO) Saint Joseph's @ George Washington | 1:00 PM | |
 Iona @ (12) Fairfield | 1:00 PM | |
(11) South Dakota State @  Omaha | 2:00 PM | |
| (FFO) Seton Hall @ DePaul | 2:00 PM | |
 Temple @ (12) UTSA | 2:00 PM | |
| Cornell @ (9) Harvard | 4:00 PM | |
(FFO) Columbia @  Dartmouth | 4:00 PM | |
(FFO) Princeton @  Brown | 4:00 PM | |
 Nevada @ (12) UNLV | 4:00 PM |
February 2
| (NFO) Auburn @ (1) South Carolina | 11:00 AM | SEC Network |
| (2) Notre Dame @ (9) Louisville | 11:00 AM | ESPN2 |
| (10) Oregon @ (8) Michigan | 11:00 AM | |
| (8) Nebraska @ (10) Indiana | 11:00 AM | FS1 |
| Butler @ (2) Connecticut | 12:00 PM | SNY |
| (11) Illinois @ (4) Maryland | 12:00 PM | |
| (1) USC @ (10) Iowa | 12:30 PM | FOX |
| (8) Mississippi State @ (2) LSU | 1:00 PM | SEC Network |
(5) Georgia Tech @  Miami (FL) | 1:00 PM | ACC Network |
 Providence @ (8) Creighton | 1:00 PM | FS1 |
 Rhode Island @ (9) Richmond | 1:00 PM | |
| SMU @ (11) Virginia Tech | 1:00 PM | |
| (10) Minnesota @ (1) UCLA | 2:00 PM | BTN |
| (2) Kansas State @ (NFO) Kansas | 2:00 PM | |
| (3) North Carolina @ (9) Stanford | 2:00 PM | |
| (3) Tennessee @ Missouri | 2:00 PM | |
| Georgia @ (4) Alabama | 2:00 PM | |
| (5) Ole Miss @ (7) Vanderbilt | 2:00 PM | |
| (5) Michigan State @ Northwestern | 2:00 PM | |
 Cincinnati @ (6) Baylor | 2:00 PM | |
| (3) TCU @ (9) Iowa State | 3:00 PM | FS1 |
| (6) Kentucky @ (4) Oklahoma | 3:00 PM | SEC Network |
| (11) Washington @ (4) Ohio State | 4:00 PM | BTN |
| Pittsburgh @ (7) California | 4:00 PM | |
| (1) Texas @ Texas A&M | 5:00 PM | SEC Network |
| Wake Forest @ (6) Florida State | 5:00 PM | ACC Network |
February 3
| (3) Duke @ (7) North Carolina State | 6:00 PM | ESPN2 |
| (NFO) Florida @ Arkansas | 6:00 PM | SEC Network |
February 4
 North Texas @ (12) UTSA | 6:30 PM |
February 5
| (11) Washington @ Penn State | 5:00 PM | |
| (9) Richmond @ La Salle | 5:30 PM | |
| (9) Iowa State @ Cincinnati | 5:30 PM | |
 Bowling Green @ (12) Ball State | 5:30 PM | |
| (NFO) Kansas @ (5) West Virginia | 6:00 PM | |
| (6) Utah @ Texas Tech | 6:00 PM | |
| (FFO) Seton Hall @ (8) Creighton | 6:00 PM | |
 VCU @ (FFO) George Mason | 6:00 PM | |
| Saint Louis @ (NFO) Saint Joseph's | 6:00 PM | |
| (1) USC @ Wisconsin | 6:30 PM | Peacock |
| (3) TCU @ (2) Kansas State | 6:30 PM | |
| (6) Baylor @ Houston | 7:00 PM | |
(11) South Dakota State @  North Dakota | 7:00 PM | |
(11) James Madison @  South Alabama | 7:00 PM | |
(12) UNLV @  Utah State | 7:00 PM | |
| (4) Ohio State @ (1) UCLA | 8:30 PM | Peacock |
February 6
| (1) South Carolina @ Georgia | 5:00 PM | |
| Rutgers @ (10) Indiana | 5:00 PM | BTN |
| Syracuse @ (11) Virginia Tech | 5:00 PM | ACC Network |
| (2) Connecticut @ (3) Tennessee | 5:30 PM | ESPN |
 Clemson @ (3) Duke | 6:00 PM | |
| (4) Alabama @ (NFO) Florida | 6:00 PM | SEC Network |
| SMU @ (5) Georgia Tech | 6:00 PM | |
| (6) Florida State @ Virginia | 6:00 PM | |
| Northwestern @ (11) Illinois | 6:00 PM | |
| Texas A&M @ (NFO) Auburn | 6:00 PM | |
(12) Fairfield @  Marist | 6:00 PM | |
| (2) LSU @ Missouri | 6:30 PM | |
| (4) Oklahoma @ (5) Ole Miss | 6:30 PM | |
| Arkansas @ (8) Mississippi State | 6:30 PM | |
| (7) California @ (9) Louisville | 7:00 PM | ACC Network |
| (8) Michigan @ (8) Nebraska | 7:00 PM | Peacock |
| (10) Iowa @ (10) Minnesota | 7:00 PM | BTN |
| (9) Stanford @ (2) Notre Dame | 7:30 PM | ESPN |
| (7) Vanderbilt @ (1) Texas | 8:00 PM | SEC Network |
| (4) Maryland @ (10) Oregon | 8:00 PM | FS1 |
February 8
 Oral Roberts @ (11) South Dakota State | 11:00 AM | |
| (NFO) Kansas @ Cincinnati | 11:00 AM | |
| (8) Creighton @ Villanova | 1:00 PM | |
| Dartmouth @ (9) Harvard | 1:00 PM | |
| (FFO) Columbia @ Brown | 1:00 PM | |
(FFO) George Mason @  Fordham | 1:00 PM | |
| Penn @ (FFO) Princeton | 1:00 PM | |
 Xavier @ (FFO) Seton Hall | 1:00 PM | FS1 |
(12) UTSA @  Wichita State | 1:00 PM | |
(12) Fairfield @  Sacred Heart | 1:00 PM | |
| (2) Kansas State @ (7) Oklahoma State | 2:00 PM | |
| (5) West Virginia @ Houston | 2:00 PM | |
| UCF @ (6) Utah | 2:30 PM | |
| Texas Tech @ (3) TCU | 4:00 PM | |
 New Mexico @ (12) UNLV | 4:00 PM | |
| Colorado @ (9) Iowa State | 5:00 PM | |
| BYU @ (6) Baylor | 7:00 PM | |
| (4) Ohio State @ (1) USC | 8:00 PM | FOX |
February 9
| (2) Connecticut @ Providence | 11:00 AM | CBSSN |
| (9) Stanford @ (9) Louisville | 11:00 AM | ESPN2 |
| (11) Virginia Tech @ Virginia | 11:00 AM | ACC Network |
| (1) South Carolina @ (1) Texas | 1:00 PM | ESPN |
| (7) California @ (2) Notre Dame | 1:00 PM | ACC Network |
| Miami (FL) @ (3) Duke | 1:00 PM | |
| (3) North Carolina @ Clemson | 1:00 PM | |
| (4) Alabama @ (8) Mississippi State | 1:00 PM | SEC Network |
| (8) Michigan @ (5) Michigan State | 1:00 PM | FS1 |
| (5) Georgia Tech @ Boston College | 1:00 PM | |
| (7) North Carolina State @ (6) Florida State | 1:00 PM | |
(9) Richmond @  Duquesne | 1:00 PM | |
| Loyola-Chicago @ (NFO) Saint Joseph's | 1:00 PM | |
| (10) Indiana @ (10) Minnesota | 2:00 PM | |
| (1) UCLA @ (10) Oregon | 3:00 PM | |
| (3) Tennessee @ (2) LSU | 3:00 PM | ESPN |
| (4) Maryland @ (11) Washington | 3:00 PM | |
| (11) Illinois @ Wisconsin | 3:00 PM |
February 10
| (6) Kentucky @ (5) Ole Miss | 6:00 PM | ESPN2 |
| (NFO) Auburn @ (4) Oklahoma | 7:00 PM | SEC Network |
| (10) Iowa @ (8) Nebraska | 7:00 PM | BTN |
February 11
| BYU @ (3) TCU | 6:30 PM | |
| (5) West Virginia @ (6) Baylor | 7:00 PM |
February 12
| (2) Kansas State @ Cincinnati | 5:30 PM | |
| Wisconsin @ (5) Michigan State | 5:30 PM | |
| (10) Indiana @ (8) Michigan | 6:00 PM | |
 Appalachian State @ (11) James Madison | 6:00 PM | |
| Rhode Island @ (FFO) George Mason | 6:00 PM | |
 Marquette @ (FFO) Seton Hall | 6:00 PM | |
| Saint John's @ (2) Connecticut | 6:30 PM | SNY |
| Arizona @ (7) Oklahoma State | 6:30 PM | |
 East Carolina @ (12) UTSA | 6:30 PM | |
| (11) South Dakota State @ North Dakota State | 7:00 PM | |
| Colorado @ (6) Utah | 8:00 PM | |
| (11) Washington @ (10) Oregon | 8:00 PM | |
| San Diego State @ (12) UNLV | 8:30 PM |
February 13
| (3) Duke @ Wake Forest | 5:00 PM | |
| (9) Louisville @ (6) Florida State | 5:00 PM | |
| Miami (FL) @ (7) North Carolina State | 5:00 PM | ACC Network |
| (NFO) Auburn @ (3) Tennessee | 5:30 PM | |
| (8) Nebraska @ (4) Maryland | 5:30 PM | BTN |
| (NFO) Florida @ (1) South Carolina | 6:00 PM | SEC Network |
| (1) Texas @ (6) Kentucky | 6:00 PM | ESPN2 |
| (11) Virginia Tech @ (3) North Carolina | 6:00 PM | |
| (5) Georgia Tech @ Clemson | 6:00 PM | |
| Penn State @ (11) Illinois | 6:00 PM | |
 Saint Peter's @ (12) Fairfield | 6:00 PM | |
| (10) Minnesota @ (4) Ohio State | 6:30 PM | Peacock |
| (5) Ole Miss @ Arkansas | 6:30 PM | |
| Rutgers @ (10) Iowa | 6:30 PM | |
| (2) Notre Dame @ Pittsburgh | 7:00 PM | ACC Network |
| (NFO) Saint Joseph's @ (9) Richmond | 7:00 PM | |
| (8) Mississippi State @ (7) Vanderbilt | 8:00 PM | SEC Network |
| (1) UCLA @ (1) USC | 9:00 PM | Peacock |
| Boston College @ (7) California | 9:00 PM | |
| Syracuse @ (9) Stanford | 9:00 PM | ACC Network |
February 14
| (9) Harvard @ Cornell | 5:00 PM | |
| Brown @ (FFO) Princeton | 5:00 PM | |
| Dartmouth @ (FFO) Columbia | 6:00 PM |
February 15
| Purdue @ (10) Indiana | 11:00 AM | BTN |
| Cincinnati @ (5) West Virginia | 1:00 PM | |
| Old Dominion @ (11) James Madison | 1:00 PM | |
| (12) Fairfield @ Manhattan | 1:00 PM | |
| (6) Baylor @ Texas Tech | 2:00 PM | |
| South Dakota @ (11) South Dakota State | 2:00 PM | |
 Memphis @ (12) UTSA | 2:00 PM | |
| (6) Utah @ Arizona State | 3:00 PM | |
| Georgetown @ (8) Creighton | 3:00 PM | FS1 |
| (12) UNLV @ Nevada | 3:00 PM | |
| UCF @ (2) Kansas State | 4:00 PM | |
| (7) Oklahoma State @ BYU | 4:00 PM | |
| (9) Iowa State @ (NFO) Kansas | 4:00 PM | |
| Yale @ (FFO) Princeton | 4:00 PM | |
(12) Ball State @  Eastern Michigan | 5:30 PM |
February 16
| (5) Ole Miss @ (3) Tennessee | 11:00 AM | SEC Network |
| Wake Forest @ (5) Georgia Tech | 11:00 AM | ACC Network |
| (9) Harvard @ (FFO) Columbia | 11:00 AM | ESPNU |
| (2) Connecticut @ (1) South Carolina | 12:00 PM | ABC |
| (7) North Carolina State @ (3) North Carolina | 1:00 PM | ESPN |
| (4) Oklahoma @ Missouri | 1:00 PM | SEC Network |
| Georgia @ (6) Kentucky | 1:00 PM | |
| (6) Florida State @ Miami (FL) | 1:00 PM | |
| (8) Mississippi State @ (NFO) Florida | 1:00 PM | |
| Saint Louis @ (9) Richmond | 1:00 PM | |
| (FFO) Seton Hall @ Providence | 1:00 PM | |
| (2) LSU @ (1) Texas | 2:00 PM | ABC |
| (10) Oregon @ (10) Minnesota | 2:00 PM | |
 UMass @ (FFO) George Mason | 2:00 PM | |
| (3) TCU @ Arizona | 3:00 PM | |
| (7) Vanderbilt @ (NFO) Auburn | 3:00 PM | SEC Network |
| (8) Nebraska @ (11) Illinois | 4:00 PM | BTN |
| Boston College @ (9) Stanford | 4:00 PM | |
| Syracuse @ (7) California | 5:00 PM | ACC Network |
| (1) USC @ (11) Washington | 6:00 PM | BTN |
| (5) Michigan State @ (1) UCLA | 8:00 PM | BTN |
February 17
| (3) Duke @ (2) Notre Dame | 0:00 | |
| (10) Iowa @ (4) Ohio State | 11:00 AM | FOX |
| (2) Kansas State @ (5) West Virginia | 1:00 PM | FOX |
| (8) Michigan @ (4) Maryland | 5:00 PM | BTN |
| Texas A&M @ (4) Alabama | 7:00 PM | SEC Network |
February 18
| UCF @ (NFO) Kansas | 6:30 PM | |
| (7) Oklahoma State @ (6) Utah | 8:00 PM |
February 19
| George Washington @ (9) Richmond | 5:00 PM | |
(11) James Madison @  Georgia State | 5:30 PM | |
| (NFO) Saint Joseph's @ Rhode Island | 5:35 PM | |
| (2) Connecticut @ (FFO) Seton Hall | 6:00 PM | SNY |
| Saint John's @ (8) Creighton | 6:00 PM | |
| (10) Minnesota @ Purdue | 6:00 PM | |
(12) Ball State @  Toledo | 6:00 PM | |
| Houston @ (9) Iowa State | 6:30 PM | |
| (10) Oregon @ (8) Nebraska | 7:00 PM | |
| (3) TCU @ Arizona State | 7:30 PM | |
| (6) Baylor @ Colorado | 8:00 PM | |
| (5) Michigan State @ (1) USC | 8:30 PM | Peacock |
February 20
| (3) North Carolina @ Syracuse | 5:00 PM | ACC Network |
| Pittsburgh @ (6) Florida State | 5:00 PM | |
| (4) Alabama @ (3) Tennessee | 5:30 PM | |
| Arkansas @ (1) South Carolina | 6:00 PM | SEC Network |
| (2) Notre Dame @ Miami (FL) | 6:00 PM | |
| (9) Louisville @ (3) Duke | 6:00 PM | ESPN2 |
| (7) Vanderbilt @ (4) Oklahoma | 6:00 PM | |
| (4) Ohio State @ (10) Indiana | 6:00 PM | Peacock |
| (7) North Carolina State @ (5) Georgia Tech | 6:00 PM | |
| (7) California @ Virginia | 6:00 PM | |
 Rider @ (12) Fairfield | 6:00 PM | |
| (4) Maryland @ Northwestern | 6:30 PM | BTN |
| (6) Kentucky @ Missouri | 6:30 PM | |
| (9) Stanford @ (11) Virginia Tech | 7:00 PM | ACC Network |
| (FFO) George Mason @ Davidson | 7:00 PM | |
| (NFO) Florida @ Texas A&M | 7:00 PM | |
| Georgia @ (2) LSU | 8:00 PM | SEC Network |
| Rutgers @ (11) Washington | 8:00 PM | |
| (11) Illinois @ (1) UCLA | 8:30 PM | BTN |
February 22
(12) UTSA @  Rice | 0:00 | |
| Penn State @ (8) Michigan | 11:00 AM | BTN |
 Kent State @ (12) Ball State | 12:00 PM | |
| (9) Harvard @ Brown | 1:00 PM | |
| (11) James Madison @ Appalachian State | 1:00 PM | |
| (9) Iowa State @ (6) Baylor | 1:30 PM | FOX |
| Colorado @ (7) Oklahoma State | 2:00 PM | |
(11) South Dakota State @  UMKC | 2:00 PM | |
(12) UNLV @  Colorado State | 2:00 PM | |
| (2) Connecticut @ Butler | 3:30 PM | SNY |
| (NFO) Kansas @ (2) Kansas State | 4:00 PM | |
| (FFO) Columbia @ (FFO) Princeton | 4:30 PM |
February 23
| (FFO) George Mason @ (NFO) Saint Joseph's | 0:00 | |
| (2) Notre Dame @ (7) North Carolina State | 11:00 AM | ESPN |
| (5) West Virginia @ (3) TCU | 11:00 AM | ESPN2 |
| Purdue @ (4) Ohio State | 11:00 AM | BTN |
| (3) Tennessee @ (NFO) Florida | 12:00 PM | SEC Network |
| (9) Richmond @ VCU | 12:00 PM | |
| (1) UCLA @ (10) Iowa | 1:00 PM | Peacock |
| Syracuse @ (3) Duke | 1:00 PM | |
| (3) North Carolina @ (9) Louisville | 1:00 PM | ESPN |
| (10) Indiana @ (5) Michigan State | 1:00 PM | BTN |
| (6) Florida State @ (5) Georgia Tech | 1:00 PM | |
| (6) Utah @ Cincinnati | 1:00 PM | |
| (7) California @ (11) Virginia Tech | 1:00 PM | ACC Network |
| (1) South Carolina @ (7) Vanderbilt | 2:00 PM | |
| (4) Oklahoma @ Arkansas | 2:00 PM | |
| Missouri @ (5) Ole Miss | 2:00 PM | SEC Network |
| (11) Washington @ (8) Nebraska | 2:00 PM | |
| Texas A&M @ (8) Mississippi State | 2:00 PM | |
| (8) Creighton @ DePaul | 2:00 PM | |
| (11) Illinois @ (1) USC | 3:00 PM | FS1 |
| (2) LSU @ (6) Kentucky | 3:00 PM | ESPN |
| (FFO) Seton Hall @ Saint John's | 3:30 PM | |
| (NFO) Auburn @ (4) Alabama | 4:00 PM | SEC Network |
| Rutgers @ (10) Oregon | 4:00 PM | |
| (9) Stanford @ Virginia | 5:00 PM | ACC Network |
February 24
| (1) Texas @ Georgia | 6:00 PM | SEC Network |
| (6) Baylor @ (2) Kansas State | 6:00 PM | ESPN2 |
February 25
| (9) Iowa State @ UCF | 6:00 PM | |
(12) UTSA @  Tulane | 6:30 PM | |
| (NFO) Kansas @ BYU | 8:00 PM |
February 26
| Davidson @ (9) Richmond | 5:00 PM | |
(12) Ball State @  Central Michigan | 5:30 PM | |
| (5) Michigan State @ (4) Ohio State | 6:00 PM | |
| (6) Utah @ (5) West Virginia | 6:00 PM | |
| (10) Iowa @ (8) Michigan | 6:00 PM | |
| Georgia State @ (11) James Madison | 6:00 PM | |
| (NFO) Saint Joseph's @ Dayton | 6:00 PM | |
| Houston @ (3) TCU | 6:30 PM | |
| Cincinnati @ (7) Oklahoma State | 6:30 PM | |
| (1) UCLA @ Wisconsin | 7:00 PM | Peacock |
| (11) Washington @ (10) Minnesota | 7:00 PM | |
 Boise State @ (12) UNLV | 8:30 PM |
February 27
| Clemson @ (9) Louisville | 5:00 PM | ACC Network |
| (NFO) Auburn @ Georgia | 5:00 PM | |
| (8) Creighton @ (2) Connecticut | 6:00 PM | CBSSN |
| (3) North Carolina @ (3) Duke | 6:00 PM | ESPN |
| (3) Tennessee @ (6) Kentucky | 6:00 PM | SEC Network |
| (4) Oklahoma @ (NFO) Florida | 6:00 PM | |
| (4) Maryland @ (10) Indiana | 6:00 PM | Peacock |
| Wake Forest @ (7) North Carolina State | 6:00 PM | |
| (11) Virginia Tech @ Boston College | 6:00 PM | |
| DePaul @ (FFO) Seton Hall | 6:00 PM | |
(12) Fairfield @  Mount Saint Mary's | 6:00 PM | |
| (1) Texas @ (8) Mississippi State | 6:30 PM | |
| Texas A&M @ (7) Vanderbilt | 6:30 PM | |
| (6) Florida State @ (2) Notre Dame | 7:00 PM | ACC Network |
 Denver @ (11) South Dakota State | 7:00 PM | |
| (1) South Carolina @ (5) Ole Miss | 8:00 PM | |
| (2) LSU @ (4) Alabama | 8:00 PM | |
| (5) Georgia Tech @ (7) California | 9:00 PM | |
| Miami (FL) @ (9) Stanford | 9:00 PM |
February 28
| Brown @ (FFO) Columbia | 3:00 PM | |
 ULM @ (11) James Madison | 6:00 PM | |
| (FFO) Princeton @ (9) Harvard | 7:00 PM |
March 1
| (12) Ball State @ Western Michigan | 12:00 PM | |
 FAU @ (12) UTSA | 12:00 PM | |
| (5) West Virginia @ Cincinnati | 1:00 PM | |
| (10) Minnesota @ (5) Michigan State | 1:00 PM | |
| (9) Richmond @ (NFO) Saint Joseph's | 1:00 PM | |
| Yale @ (FFO) Columbia | 1:00 PM | |
| Saint Thomas @ (11) South Dakota State | 2:00 PM | |
| Duquesne @ (FFO) George Mason | 2:00 PM | |
| BYU @ (6) Utah | 2:30 PM | |
 San Jose State @ (12) UNLV | 4:00 PM | |
| Penn @ (9) Harvard | 6:00 PM | |
| (FFO) Princeton @ Dartmouth | 6:00 PM | |
| Sacred Heart @ (12) Fairfield | 6:00 PM | |
| (1) USC @ (1) UCLA | 8:00 PM | FOX |
March 2
| (10) Oregon @ (11) Washington | 0:00 | |
| (9) Louisville @ (2) Notre Dame | 11:00 AM | ESPN |
| Georgia @ (3) Tennessee | 11:00 AM | SEC Network |
| (7) North Carolina State @ SMU | 11:00 AM | ACC Network |
| (6) Kentucky @ (1) South Carolina | 1:00 PM | ESPN |
| (NFO) Florida @ (1) Texas | 1:00 PM | SEC Network |
| Virginia @ (3) North Carolina | 1:00 PM | |
| (10) Indiana @ Purdue | 1:00 PM | Peacock |
| (11) Virginia Tech @ Clemson | 1:00 PM | ACC Network |
| (FFO) Seton Hall @ Xavier | 1:00 PM | |
| Marquette @ (2) Connecticut | 1:30 PM | FOX |
| (4) Alabama @ (4) Oklahoma | 1:30 PM | |
| (7) Oklahoma State @ (NFO) Kansas | 2:00 PM | |
| Missouri @ (7) Vanderbilt | 2:00 PM | |
| (8) Michigan @ (11) Illinois | 2:00 PM | |
| (8) Nebraska @ Northwestern | 2:00 PM | |
| (8) Mississippi State @ (NFO) Auburn | 2:00 PM | |
| (5) Ole Miss @ (2) LSU | 3:00 PM | SEC Network |
| (2) Kansas State @ (9) Iowa State | 3:00 PM | ESPN2 |
| Wisconsin @ (10) Iowa | 3:00 PM | Peacock |
| (4) Ohio State @ (4) Maryland | 4:00 PM | FOX |
| (5) Georgia Tech @ (9) Stanford | 4:00 PM | |
| Miami (FL) @ (7) California | 4:00 PM | |
| (3) Duke @ (6) Florida State | 5:00 PM | ACC Network |
| (3) TCU @ (6) Baylor | 5:30 PM | FS1 |
| Villanova @ (8) Creighton | 7:30 PM | FS1 |
March 4
| (12) UTSA @ East Carolina | 5:00 PM |
March 5
 Buffalo @ (12) Ball State | 5:30 PM | |
(12) UNLV @  Wyoming | 9:30 PM | FS1 |
March 6
 Siena @ (12) Fairfield | 6:00 PM |
March 8
| Ohio @ (12) Ball State | 12:00 PM | |
| (9) Harvard @ Dartmouth | 1:00 PM | |
| Cornell @ (FFO) Columbia | 1:00 PM | |
| (FFO) Princeton @ Penn | 1:00 PM | |
| (12) Fairfield @ Quinnipiac | 3:00 PM |