December 21
 Oakland @ (2)  Michigan | 11:00 AM | B1G+ |
 California Baptist @ (2)  Nebraska | 11:00 AM | B1G+ |
 Charleston Southern @ (5)  North Carolina | 11:00 AM | ACC Extra |
(7)  North Carolina State @ (NFO)  Davidson | 11:00 AM | CBSSN |
(9)  Georgia v.  Coppin State | 11:00 AM | ESPN+ |
 Kennesaw State @ (11)  Miami (FL) | 11:00 AM | ACC Network |
 Radford @ (FFO)  Virginia Tech | 11:00 AM | ACC Extra |
 Kansas @ (4)  Iowa State | 12:00 PM | ESPN2 |
 Western Carolina @ (NFO)  Indiana | 12:00 PM | B1G+ |
(1)  Texas @  South Dakota State | 1:00 PM | CBSSN |
 UTA @ (2)  LSU | 1:00 PM | SEC Network |
 Houston @ (6)  West Virginia | 1:00 PM | ESPN+ |
(7)  Oklahoma State @  Cincinnati | 1:00 PM | ESPN+ |
 Merrimack @ (11)  Fairfield | 1:00 PM | ESPN+ |
 North Florida @ (NFO)  Clemson | 1:00 PM | ACC Network |
(11)  Richmond v.  Penn State | 1:30 PM | ESPN+ |
 Tulsa @ (FFO)  Florida | 1:45 PM | SECN+ |
(5)  Minnesota @  Drake | 2:00 PM | ESPN+ |
(10)  Troy @ (7)  Alabama | 2:00 PM | SECN+ |
(12)  Santa Clara @  North Texas | 2:00 PM | ESPN+ |
(3)  Texas Tech @ (10)  Baylor | 3:00 PM | ESPN+ |
(10)  Washington @  Pacific | 3:00 PM | ESPN+ |
(3)  Michigan State v.  Indiana State | 4:00 PM | |
(5)  Oregon v. (8)  Stanford | 5:00 PM | ESPN |
 Bellarmine @ (7)  Notre Dame | 6:00 PM | ACC Extra |
(FFO)  Colorado @ (11)  Arizona State | 6:00 PM | ESPN+ |
(5)  Ole Miss v.  Old Dominion | 6:30 PM | |
(6)  USC v.  California | 7:30 PM | ESPN |
December 22
 Temple @ (8)  Princeton | 10:30 AM | ESPN+ |
 Saint John's @ (8)  Villanova | 11:00 AM | ESPN+ |
 North Carolina Central @ (4)  Oklahoma | 12:00 PM | SECN+ |
(NFO)  Utah @  Arizona | 1:00 PM | ESPN+ |
 Western Michigan @ (9)  Ohio State | 5:30 PM | |
(12)  Southern Indiana @ (9)  Tennessee | 5:30 PM | SECN+ |
December 28
 San Diego @ (12) Santa Clara | 0:00 | |
 Providence @ (1)  South Carolina | 11:00 AM | SEC Network |
(8)  Illinois @  Purdue | 11:00 AM | BTN |
 Southeastern Louisiana @ (1) Texas | 1:00 PM | SEC Network |
(1)  UCLA @ (9) Ohio State | 1:00 PM | BTN |
 Rutgers @ (3) Michigan State | 1:00 PM | B1G+ |
 Hofstra @ (4)  Kentucky | 1:00 PM | SECN+ |
 Stetson @ (11) Miami (FL) | 1:00 PM | ACC Network |
 Furman @ (FFO) Florida | 1:00 PM | SECN+ |
(NFO) Clemson @  Chicago State | 1:00 PM | |
 Stonehill @ (3)  Vanderbilt | 2:00 PM | SECN+ |
 Alcorn State @ (5) Ole Miss | 2:00 PM | SECN+ |
 Samford @ (9)  Mississippi State | 2:00 PM | SECN+ |
(1)  Connecticut @  Butler | 3:00 PM | |
 Alabama State @ (2) LSU | 3:00 PM | SEC Network |
Penn State @ (3)  Iowa | 3:00 PM | BTN |
(6)  Duke @ (11)  Syracuse | 3:00 PM | ACC Network |
 Cornell @ (8) Stanford | 3:00 PM | ACC Extra |
December 29
 Northwestern @ (10) Washington | 0:00 | |
| Charleston Southern @ (9) Georgia | 11:00 AM | SECN+ |
| (6) USC @ (2) Nebraska | 2:00 PM | |
 Wisconsin @ (6)  Maryland | 3:00 PM | |
| (5) Minnesota @ (NFO) Indiana | 5:00 PM | |
 Pittsburgh @ (7) Notre Dame | 5:00 PM | ACC Network |
(8) Villanova @  DePaul | 6:00 PM | ESPN+ |
 SMU @ (11)  Virginia | 6:00 PM | ACC Extra |
(11) Fairfield @  Manhattan | 6:00 PM | ESPN+ |
(5) North Carolina @  Boston College | 7:00 PM | ACC Network |
| (2) Michigan @ (5) Oregon | 8:00 PM |
December 30
 Seattle University @ (12) Santa Clara | 0:00 | |
(11) Richmond @ (FFO)  Rhode Island | 5:00 PM | ESPN+ |
December 31
(12)  Colorado State @  Grand Canyon | 0:00 | |
| (9) Ohio State @ Purdue | 11:00 AM | BTN |
| (1) UCLA @ Penn State | 1:00 PM | |
| (4) Iowa State @ Houston | 1:00 PM | ESPN+ |
| (1) Connecticut @ Providence | 2:00 PM | |
| (10) Baylor @ (7) Oklahoma State | 2:00 PM | |
(NFO) Davidson @  Loyola-Chicago | 2:00 PM | ESPN+ |
| (11) Arizona State @ (NFO) Utah | 3:00 PM | ESPN+ |
 UCF @ (3) Texas Tech | 6:00 PM | ESPN+ |
(2)  TCU @ (10)  BYU | 8:00 PM | ESPN+ |
| Arizona @ (FFO) Colorado | 8:00 PM | ESPN+ |
January 1
(1) Texas @  Missouri | 0:00 | |
| (4) Kentucky @ (2) LSU | 0:00 | |
| (9) Georgia @ (5) Ole Miss | 0:00 | |
 Creighton @ (8) Villanova | 0:00 | ESPN+ |
 Auburn @ (9) Mississippi State | 0:00 | |
| (FFO) Florida @ (9) Tennessee | 0:00 | |
(10) Troy @  Louisiana | 0:00 | ESPN+ |
(12)  North Dakota State @  Oral Roberts | 0:00 | |
| (3) Michigan State @ (NFO) Indiana | 11:00 AM | BTN |
| California @ (5) North Carolina | 11:00 AM | ACC Network |
| (6) West Virginia @ Kansas | 12:00 PM | ESPN+ |
| Boston College @ (6) Duke | 12:00 PM | |
| (7) Alabama @ (1) South Carolina | 1:00 PM | |
| (2) Nebraska @ (3) Iowa | 1:00 PM | BTN |
(3) Vanderbilt @  Arkansas | 1:00 PM | |
SMU @ (4)  Louisville | 1:00 PM | |
| (8) Stanford @ (7) North Carolina State | 1:00 PM | ACC Network |
 Canisius @ (11) Fairfield | 1:00 PM | ESPN+ |
(12) Southern Indiana @  SIUE | 1:00 PM | ESPN+ |
| (6) Maryland @ (8) Illinois | 3:00 PM | BTN |
(7) Notre Dame @  Georgia Tech | 3:00 PM | ACC Network |
| Northwestern @ (5) Oregon | 4:00 PM | |
| (2) Michigan @ (10) Washington | 5:00 PM | BTN |
 Florida State @ (11) Syracuse | 5:00 PM | |
| (11) Miami (FL) @ (FFO) Virginia Tech | 5:00 PM | |
| (NFO) Clemson @ (11) Virginia | 6:00 PM | |
(4) Oklahoma @  Texas A&M | 7:00 PM |
January 2
(12) Santa Clara @  Loyola-Marymount | 0:00 |
January 3
 Niagara @ (11) Fairfield | 0:00 | ESPN+ |
(12) North Dakota State @  Denver | 0:00 | |
 Fresno State @ (12) Colorado State | 0:00 | |
 Seton Hall @ (1) Connecticut | 11:00 AM | |
(8) Princeton @  Penn | 1:00 PM | ESPN+ |
(12) Southern Indiana @  Lindenwood | 1:00 PM | ESPN+ |
(10) Troy @  Southern Miss | 2:00 PM | ESPN+ |
(11) Richmond @  Saint Bonaventure | 2:00 PM | ESPN+ |
| Cincinnati @ (FFO) Colorado | 2:00 PM | ESPN+ |
(NFO) Davidson @  Saint Louis | 2:00 PM | ESPN+ |
| Houston @ (7) Oklahoma State | 3:00 PM | |
| (11) Arizona State @ (10) BYU | 3:00 PM | ESPN+ |
| Arizona @ (3) Texas Tech | 6:00 PM | ESPN+ |
| (6) USC @ (1) UCLA | 7:00 PM | |
| (FFO) Rhode Island @ Loyola-Chicago | 7:00 PM | ESPN+ |
| (2) TCU @ (NFO) Utah | 8:00 PM | ESPN+ |
January 4
| (8) Stanford @ (5) North Carolina | 0:00 | |
| (7) Notre Dame @ (6) Duke | 0:00 | |
| Arkansas @ (7) Alabama | 0:00 | |
| (8) Illinois @ (3) Michigan State | 11:00 AM | BTN |
| Missouri @ (4) Kentucky | 11:00 AM | SEC Network |
| (1) South Carolina @ (FFO) Florida | 1:00 PM | SEC Network |
(6) West Virginia @  Kansas State | 1:00 PM | ESPN+ |
| California @ (7) North Carolina State | 1:00 PM | |
| Rutgers @ (9) Ohio State | 1:00 PM | BTN |
| Texas A&M @ (9) Georgia | 1:00 PM | |
| (11) Virginia @ Florida State | 1:00 PM | ACC Network |
(11) Syracuse @  Wake Forest | 1:00 PM | |
| (NFO) Clemson @ (11) Miami (FL) | 1:00 PM | |
| (5) Ole Miss @ (1) Texas | 2:00 PM | |
| Purdue @ (2) Nebraska | 2:00 PM | |
| (9) Mississippi State @ (4) Oklahoma | 2:00 PM | |
 Gonzaga @ (12) Santa Clara | 2:00 PM | |
| (FFO) Virginia Tech @ (4) Louisville | 3:00 PM | ACC Network |
(8) Villanova @  Marquette | 3:00 PM | |
| (9) Tennessee @ Auburn | 3:00 PM | SEC Network |
| (2) LSU @ (3) Vanderbilt | 4:00 PM | ESPN |
| (10) Baylor @ (4) Iowa State | 4:00 PM | |
| (NFO) Indiana @ (6) Maryland | 5:00 PM | BTN |
January 5
| (5) Minnesota @ (2) Michigan | 5:30 PM | BTN |
| (3) Iowa @ Northwestern | 7:30 PM | BTN |
January 6
| (10) BYU @ Arizona | 7:00 PM | ESPN+ |
| (5) Oregon @ (6) USC | 9:00 PM | BTN |
January 7
| (3) Texas Tech @ (6) West Virginia | 0:00 | ESPN+ |
 Texas State @ (10) Troy | 0:00 | ESPN+ |
 New Mexico @ (12) Colorado State | 0:00 | |
(FFO) Rhode Island @  George Washington | 10:00 AM | ESPN+ |
| Saint John's @ (1) Connecticut | 12:00 PM | |
 Fordham @ (11) Richmond | 5:00 PM | ESPN+ |
 Saint Joseph's @ (NFO) Davidson | 5:00 PM | ESPN+ |
| (4) Iowa State @ Cincinnati | 5:30 PM | ESPN+ |
| (9) Ohio State @ (8) Illinois | 6:00 PM | |
| (7) Oklahoma State @ (2) TCU | 6:30 PM | ESPN+ |
| (NFO) Utah @ Kansas | 6:30 PM | ESPN+ |
| UCF @ (11) Arizona State | 7:30 PM |
January 8
| (1) South Carolina @ Arkansas | 0:00 | |
| Auburn @ (1) Texas | 0:00 | |
| (2) LSU @ (9) Georgia | 0:00 | |
| Missouri @ (3) Vanderbilt | 0:00 | |
| (4) Kentucky @ (7) Alabama | 0:00 | |
 Xavier @ (8) Villanova | 0:00 | ESPN+ |
| (9) Tennessee @ (9) Mississippi State | 0:00 | |
(11) Fairfield @  Saint Peter's | 0:00 | ESPN+ |
| (2) Michigan @ Penn State | 5:00 PM | |
| (6) Duke @ California | 5:00 PM | ACC Network |
| Boston College @ (7) Notre Dame | 5:00 PM | |
| (FFO) Virginia Tech @ (11) Syracuse | 5:00 PM | |
 Southeast Missouri @ (12) Southern Indiana | 5:00 PM | ESPN+ |
| (4) Louisville @ (11) Miami (FL) | 6:00 PM | |
| (5) Ole Miss @ (4) Oklahoma | 6:00 PM | |
| (6) Maryland @ Rutgers | 6:00 PM | B1G+ |
| (11) Virginia @ Georgia Tech | 6:00 PM | |
| Texas A&M @ (FFO) Florida | 6:00 PM | |
| (NFO) Indiana @ (2) Nebraska | 7:00 PM | |
| Northwestern @ (5) Minnesota | 7:00 PM | |
| (7) North Carolina State @ (NFO) Clemson | 7:00 PM | ACC Network |
| (FFO) Colorado @ (10) Baylor | 7:00 PM | ESPN+ |
 UMKC @ (12) North Dakota State | 7:00 PM | |
| (3) Michigan State @ (10) Washington | 8:00 PM | |
(12) Santa Clara @  San Francisco | 8:00 PM | |
| Wake Forest @ (8) Stanford | 9:00 PM |
January 10
(12) Colorado State @  Boise State | 0:00 | |
| Saint Bonaventure @ (FFO) Rhode Island | 12:00 PM | ESPN+ |
| (3) Texas Tech @ Cincinnati | 1:00 PM | ESPN+ |
(8) Princeton @  Yale | 1:00 PM | ESPN+ |
| (10) BYU @ Houston | 1:00 PM | ESPN+ |
 Omaha @ (12) North Dakota State | 1:00 PM | |
(12) Santa Clara @  Washington State | 2:00 PM | |
 Arkansas State @ (10) Troy | 3:33 PM | ESPN+ |
| (NFO) Utah @ Kansas State | 4:00 PM | ESPN+ |
| (NFO) Davidson @ (11) Richmond | 5:00 PM | ESPN+ |
 Tennessee-Martin @ (12) Southern Indiana | 5:00 PM | ESPN+ |
January 11
| (8) Villanova @ Providence | 11:00 AM | |
| Boston College @ (FFO) Virginia Tech | 11:00 AM | ACC Network |
| (5) North Carolina @ (7) Notre Dame | 12:00 PM | ESPN |
| (9) Georgia @ (1) South Carolina | 1:00 PM | SEC Network |
| (1) Connecticut @ Creighton | 1:00 PM | |
| Wisconsin @ (2) Michigan | 1:00 PM | |
| Pittsburgh @ (4) Louisville | 1:00 PM | |
| (6) West Virginia @ (4) Iowa State | 1:00 PM | ESPN+ |
| (FFO) Colorado @ (7) Oklahoma State | 1:00 PM | |
| Arkansas @ (9) Tennessee | 1:00 PM | |
| (10) Washington @ Purdue | 1:00 PM | |
| (11) Syracuse @ (11) Virginia | 1:00 PM | |
| Florida State @ (11) Miami (FL) | 1:00 PM | ACC Network |
| (1) Texas @ (2) LSU | 2:00 PM | ESPN |
| (3) Vanderbilt @ Texas A&M | 2:00 PM | |
| (6) USC @ (5) Minnesota | 2:00 PM | |
| (8) Illinois @ Penn State | 2:00 PM | BTN |
| Kansas @ (10) Baylor | 2:00 PM | ESPN+ |
| (FFO) Florida @ Auburn | 2:00 PM | |
| (4) Oklahoma @ (4) Kentucky | 3:00 PM | SEC Network |
| (9) Ohio State @ (6) Maryland | 3:00 PM | |
| (NFO) Clemson @ Georgia Tech | 3:00 PM | ACC Network |
| (11) Arizona State @ (2) TCU | 4:00 PM | ESPN+ |
| (3) Michigan State @ (5) Oregon | 4:00 PM | |
| (3) Iowa @ (NFO) Indiana | 4:00 PM | BTN |
| (6) Duke @ (8) Stanford | 4:00 PM | ESPN |
| (9) Mississippi State @ (5) Ole Miss | 5:00 PM | SEC Network |
| SMU @ (7) North Carolina State | 5:00 PM | ACC Network |
| (1) UCLA @ (2) Nebraska | 6:00 PM | BTN |
January 12
| (7) Alabama @ Missouri | 6:00 PM | SEC Network |
January 13
| Houston @ (3) Texas Tech | 6:00 PM | ESPN+ |
January 14
(FFO) Rhode Island @  VCU | 0:00 | ESPN+ |
(12) Colorado State @  Air Force | 0:00 | |
(11) Fairfield @  Marist | 10:00 AM | ESPN+ |
| Penn State @ (9) Ohio State | 5:30 PM | |
| (2) TCU @ (6) West Virginia | 6:00 PM | ESPN+ |
| (10) Washington @ (NFO) Indiana | 6:00 PM | |
(11) Richmond @  Dayton | 6:00 PM | ESPN+ |
| Fordham @ (NFO) Davidson | 6:00 PM | ESPN+ |
| (7) Oklahoma State @ Kansas | 6:30 PM | ESPN+ |
(10) Troy @  ULM | 6:30 PM | ESPN+ |
| (1) UCLA @ (5) Minnesota | 7:00 PM | |
| (4) Iowa State @ (FFO) Colorado | 8:00 PM | ESPN+ |
| (10) Baylor @ (NFO) Utah | 8:00 PM | ESPN+ |
January 15
 Portland @ (12) Santa Clara | 0:00 | |
| (4) Louisville @ (7) Notre Dame | 5:00 PM | ACC Network |
| (7) North Carolina State @ Wake Forest | 5:00 PM | |
| (8) Stanford @ Boston College | 5:00 PM | |
| California @ (11) Syracuse | 5:00 PM | |
| (3) Vanderbilt @ (9) Mississippi State | 5:30 PM | SEC Network |
(12) Southern Indiana @  Tennessee Tech | 5:30 PM | ESPN+ |
| (1) Texas @ (1) South Carolina | 6:00 PM | ESPN2 |
| (8) Villanova @ (1) Connecticut | 6:00 PM | |
| (8) Illinois @ (2) Michigan | 6:00 PM | Peacock |
| (2) Nebraska @ (3) Michigan State | 6:00 PM | BTN |
| (FFO) Florida @ (4) Kentucky | 6:00 PM | |
| (11) Miami (FL) @ (5) North Carolina | 6:00 PM | |
| (FFO) Virginia Tech @ SMU | 6:30 PM | |
| (11) Virginia @ (6) Duke | 7:00 PM | ACC Network |
| (5) Oregon @ (3) Iowa | 8:00 PM | |
| (6) Maryland @ (6) USC | 8:00 PM | |
| (7) Alabama @ Auburn | 8:00 PM | SEC Network |
January 17
| (10) Troy @ Texas State | 0:00 | ESPN+ |
| Manhattan @ (11) Fairfield | 0:00 | ESPN+ |
 San Jose State @ (12) Colorado State | 0:00 | |
| Kansas State @ (3) Texas Tech | 1:00 PM | ESPN+ |
 Dartmouth @ (8) Princeton | 1:00 PM | ESPN+ |
| (NFO) Utah @ Houston | 1:00 PM | ESPN+ |
(12) Southern Indiana @  Tennessee State | 1:00 PM | ESPN+ |
| (12) North Dakota State @ South Dakota State | 2:00 PM | |
| (10) Baylor @ (10) BYU | 3:00 PM | ESPN+ |
| Kansas @ (11) Arizona State | 3:00 PM | |
| Arizona @ (2) TCU | 4:00 PM | ESPN+ |
(12) Santa Clara @  Saint Mary's College | 8:30 PM |
January 18
| (4) Kentucky @ (9) Mississippi State | 0:00 | |
| Butler @ (8) Villanova | 0:00 | ESPN+ |
| Missouri @ (FFO) Florida | 0:00 | |
| (1) South Carolina @ Coppin State | 11:00 AM | ESPN+ |
| (5) Ole Miss @ (9) Georgia | 11:00 AM | SEC Network |
| VCU @ (11) Richmond | 11:00 AM | ESPN+ |
 Duquesne @ (FFO) Rhode Island | 11:00 AM | |
| Wake Forest @ (NFO) Clemson | 11:00 AM | ACC Network |
| (4) Louisville @ (7) North Carolina State | 12:00 PM | ESPN2 |
| (4) Iowa State @ (7) Oklahoma State | 12:00 PM | |
(NFO) Davidson @  La Salle | 12:00 PM | ESPN+ |
| (5) North Carolina @ Florida State | 1:00 PM | |
| (6) West Virginia @ Cincinnati | 1:00 PM | ESPN+ |
| (9) Tennessee @ (7) Alabama | 1:00 PM | SEC Network |
| (8) Stanford @ (11) Syracuse | 1:00 PM | ACC Network |
| (FFO) Colorado @ UCF | 1:00 PM | ESPN+ |
| (2) LSU @ (4) Oklahoma | 2:00 PM | |
| (5) Oregon @ Wisconsin | 2:00 PM | BTN |
| Northwestern @ (8) Illinois | 2:00 PM | |
| Texas A&M @ (1) Texas | 3:00 PM | SEC Network |
| (6) Maryland @ (1) UCLA | 3:00 PM | |
| Purdue @ (6) USC | 4:00 PM | |
| (5) Minnesota @ (10) Washington | 5:00 PM | BTN |
| Georgia Tech @ (6) Duke | 5:00 PM | ACC Network |
| (3) Michigan State @ (3) Iowa | 7:00 PM | BTN |
January 19
| (2) TCU v. (9) Ohio State | 11:00 AM | |
 Harvard @ (8) Princeton | 1:00 PM | ESPN+ |
 Siena @ (11) Fairfield | 1:00 PM | ESPN+ |
| (2) Michigan v. (3) Vanderbilt | 1:30 PM | |
| (7) Notre Dame @ (1) Connecticut | 4:00 PM |
January 21
| Grand Canyon @ (12) Colorado State | 0:00 | |
| (NFO) Davidson @ (FFO) Rhode Island | 5:00 PM | ESPN+ |
| (11) Arizona State @ (6) West Virginia | 6:00 PM | ESPN+ |
| (2) Nebraska @ Wisconsin | 6:30 PM | |
| Cincinnati @ (4) Iowa State | 6:30 PM | ESPN+ |
| UCF @ (10) Baylor | 7:00 PM | ESPN+ |
(12) North Dakota State @  Saint Thomas | 7:00 PM | |
| (3) Texas Tech @ (10) BYU | 8:00 PM | ESPN+ |
| (5) Minnesota @ (5) Oregon | 8:00 PM | |
| Penn State @ (10) Washington | 8:00 PM | |
| Purdue @ (1) UCLA | 9:00 PM |
January 22
| Auburn @ (3) Vanderbilt | 0:00 | |
| (5) Ole Miss @ Missouri | 0:00 | |
| (11) Fairfield @ Niagara | 0:00 | ESPN+ |
| (12) Santa Clara @ Seattle University | 0:00 | |
| (2) Michigan @ Rutgers | 5:00 PM | BTN |
| (3) Iowa @ (6) Maryland | 5:00 PM | |
| (11) Miami (FL) @ (7) Notre Dame | 5:00 PM | ACC Network |
| (NFO) Clemson @ (FFO) Virginia Tech | 5:00 PM | |
 Eastern Illinois @ (12) Southern Indiana | 5:00 PM | ESPN+ |
| (4) Kentucky @ (9) Tennessee | 5:30 PM | SEC Network |
| (1) South Carolina @ (4) Oklahoma | 6:00 PM | ESPN |
 Georgia Southern @ (10) Troy | 6:00 PM | ESPN+ |
| Pittsburgh @ (11) Virginia | 6:00 PM | |
(1) Connecticut v.  Georgetown | 6:30 PM | |
| (9) Georgia @ Arkansas | 6:30 PM | |
| (6) USC @ (3) Michigan State | 7:00 PM | BTN |
| (5) North Carolina @ Georgia Tech | 7:00 PM | ACC Network |
| (NFO) Indiana @ (9) Ohio State | 7:00 PM | Peacock |
| (2) LSU @ Texas A&M | 8:00 PM | SEC Network |
January 24
| (8) Villanova @ Saint John's | 0:00 | |
 Georgia State @ (10) Troy | 0:00 | ESPN+ |
 South Dakota @ (12) North Dakota State | 0:00 | |
| (12) Colorado State @ Fresno State | 0:00 | |
(8) Princeton @  Brown | 11:00 AM | ESPN+ |
| (11) Fairfield @ Canisius | 12:00 PM | ESPN+ |
| (2) TCU @ UCF | 1:00 PM | ESPN+ |
| (8) Illinois @ (2) Nebraska | 1:00 PM | BTN |
| (11) Arizona State @ Cincinnati | 1:00 PM | ESPN+ |
 Western Illinois @ (12) Southern Indiana | 1:00 PM | ESPN+ |
| Arizona @ (4) Iowa State | 3:00 PM | |
| Penn State @ (5) Oregon | 4:00 PM | |
| (3) Texas Tech @ (NFO) Utah | 6:00 PM | ESPN+ |
| (6) West Virginia @ (10) BYU | 8:30 PM | ESPN+ |
January 25
| (NFO) Indiana @ Purdue | 0:00 | |
| (1) Connecticut @ Seton Hall | 11:00 AM | |
| (9) Georgia @ (4) Kentucky | 11:00 AM | SEC Network |
| (7) North Carolina State @ (11) Virginia | 11:00 AM | ACC Network |
| VCU @ (NFO) Davidson | 11:00 AM | |
| (6) USC @ (2) Michigan | 1:00 PM | BTN |
| (9) Ohio State @ (3) Iowa | 1:00 PM | |
| Boston College @ (4) Louisville | 1:00 PM | |
| (4) Oklahoma @ Auburn | 1:00 PM | SEC Network |
| (11) Syracuse @ (5) North Carolina | 1:00 PM | |
| (6) Duke @ Pittsburgh | 1:00 PM | ACC Network |
| (10) Washington @ Rutgers | 1:00 PM | B1G+ |
(11) Richmond @  George Mason | 1:00 PM | ESPNU |
| (FFO) Rhode Island @ Dayton | 1:00 PM | ESPN+ |
| (FFO) Virginia Tech @ Wake Forest | 1:00 PM | |
| (3) Vanderbilt @ (1) South Carolina | 2:00 PM | ESPN |
| Wisconsin @ (5) Minnesota | 2:00 PM | |
| (NFO) Clemson @ (7) Notre Dame | 2:00 PM | |
| (9) Mississippi State @ (7) Alabama | 2:00 PM | |
| (7) Oklahoma State @ (FFO) Colorado | 2:00 PM | ESPN+ |
| Houston @ (10) Baylor | 2:00 PM | ESPN+ |
| (1) Texas @ Arkansas | 3:00 PM | SEC Network |
| (1) UCLA @ Northwestern | 3:00 PM | BTN |
| (11) Miami (FL) @ SMU | 3:00 PM | |
| (8) Stanford @ California | 5:00 PM | ACC Network |
January 26
| (9) Tennessee @ (5) Ole Miss | 6:00 PM | ESPNU |
| (FFO) Florida @ (2) LSU | 7:00 PM | SEC Network |
January 27
| Providence @ (8) Villanova | 6:00 PM | ESPN+ |
| (6) West Virginia @ (NFO) Utah | 8:00 PM | ESPN+ |
January 28
 San Diego State @ (12) Colorado State | 0:00 | |
| (5) Minnesota @ Penn State | 5:00 PM | |
(10) Troy @  Marshall | 5:00 PM | ESPN+ |
| Duquesne @ (11) Richmond | 5:00 PM | ESPN+ |
| (1) UCLA @ (8) Illinois | 6:00 PM | |
| (4) Iowa State @ (3) Texas Tech | 6:00 PM | ESPN+ |
| (5) Oregon @ Rutgers | 6:00 PM | B1G+ |
| (10) Washington @ (6) Maryland | 6:00 PM | |
| George Mason @ (NFO) Davidson | 6:00 PM | ESPN+ |
| (10) BYU @ (7) Oklahoma State | 6:30 PM | |
| Xavier @ (1) Connecticut | 7:00 PM | |
| Northwestern @ (2) Nebraska | 7:00 PM | |
| Arizona @ (11) Arizona State | 7:30 PM |
January 29
| (3) Vanderbilt @ (5) Ole Miss | 0:00 | |
| (9) Mississippi State @ (9) Tennessee | 0:00 | |
| Denver @ (12) North Dakota State | 0:00 | |
| Kansas @ (2) TCU | 5:00 PM | ESPN |
| (3) Michigan State @ Purdue | 5:00 PM | BTN |
| (7) North Carolina State @ Boston College | 5:00 PM | ACC Network |
| (11) Virginia @ Wake Forest | 5:00 PM | |
| Georgia Tech @ (11) Syracuse | 5:00 PM | |
| Pittsburgh @ (FFO) Virginia Tech | 5:00 PM | |
| Lindenwood @ (12) Southern Indiana | 5:00 PM | ESPN+ |
| (7) Alabama @ (9) Georgia | 5:30 PM | SEC Network |
| (1) Texas @ (FFO) Florida | 6:00 PM | |
| (2) Michigan @ (NFO) Indiana | 6:00 PM | Peacock |
| Texas A&M @ (4) Oklahoma | 6:00 PM | |
| Wisconsin @ (9) Ohio State | 6:00 PM | BTN |
 Quinnipiac @ (11) Fairfield | 6:00 PM | ESPN+ |
| SMU @ (NFO) Clemson | 6:00 PM | |
| (FFO) Colorado @ Kansas State | 6:30 PM | ESPN+ |
| Arkansas @ (2) LSU | 7:00 PM | |
| (4) Louisville @ (8) Stanford | 7:00 PM | ESPN |
| (6) Duke @ (11) Miami (FL) | 7:00 PM | ACC Network |
| (1) South Carolina @ Auburn | 8:00 PM | SEC Network |
| (3) Iowa @ (6) USC | 8:00 PM | |
| Washington State @ (12) Santa Clara | 8:00 PM | |
| (7) Notre Dame @ California | 9:00 PM |
January 30
 Columbia @ (8) Princeton | 5:00 PM | ESPNU |
January 31
| (5) Oregon @ (6) Maryland | 0:00 | BTN |
| DePaul @ (8) Villanova | 0:00 | ESPN+ |
(10) Troy @  Coastal Carolina | 0:00 | ESPN+ |
 Pepperdine @ (12) Santa Clara | 0:00 | |
| Oral Roberts @ (12) North Dakota State | 0:00 | |
(12) Colorado State @  UNLV | 0:00 | |
| UCF @ (4) Iowa State | 1:00 PM | ESPN+ |
(11) Fairfield @  Sacred Heart | 1:00 PM | ESPN+ |
| (FFO) Rhode Island @ Fordham | 1:00 PM | ESPN+ |
| (NFO) Utah @ (10) BYU | 3:00 PM | ESPN+ |
| Cornell @ (8) Princeton | 4:00 PM | ESPN+ |
| SIUE @ (12) Southern Indiana | 5:00 PM | ESPN+ |
February 1
| Auburn @ (5) Ole Miss | 0:00 | |
| Missouri @ (9) Mississippi State | 0:00 | |
| (9) Tennessee @ (1) Connecticut | 11:00 AM | |
| (2) Michigan @ (3) Michigan State | 11:00 AM | |
| (7) Alabama @ (2) LSU | 11:00 AM | SEC Network |
| (10) Baylor @ (6) West Virginia | 11:00 AM | ESPN |
| Wake Forest @ (6) Duke | 11:00 AM | ACC Network |
| (11) Richmond @ VCU | 11:00 AM | ESPNU |
| (4) Louisville @ California | 12:00 PM | |
| (2) TCU @ (3) Texas Tech | 1:00 PM | |
| (4) Kentucky @ Arkansas | 1:00 PM | SEC Network |
| (11) Virginia @ (FFO) Virginia Tech | 1:00 PM | |
| (11) Syracuse @ (11) Miami (FL) | 1:00 PM | |
| Northwestern @ (NFO) Indiana | 1:00 PM | |
| (NFO) Davidson @ Saint Joseph's | 1:00 PM | ESPN+ |
| (4) Oklahoma @ (1) Texas | 2:00 PM | ABC |
| Purdue @ (5) Minnesota | 2:00 PM | |
| (FFO) Colorado @ Kansas | 2:00 PM | ESPN+ |
| (3) Iowa @ (1) UCLA | 3:00 PM | |
| (FFO) Florida @ (3) Vanderbilt | 3:00 PM | SEC Network |
| (7) Notre Dame @ (8) Stanford | 3:00 PM | |
| (7) Oklahoma State @ Arizona | 3:00 PM | ESPN+ |
| Kansas State @ (11) Arizona State | 3:00 PM | |
| Rutgers @ (6) USC | 4:00 PM | B1G+ |
| (2) Nebraska @ (9) Ohio State | 5:00 PM | BTN |
| (8) Illinois @ (10) Washington | 5:00 PM | FS1 |
| Florida State @ (NFO) Clemson | 5:00 PM | ACC Network |
February 2
| (5) North Carolina @ (7) North Carolina State | 5:00 PM | ESPN2 |
| (1) South Carolina @ Texas A&M | 7:00 PM |
February 4
| (8) Villanova @ Butler | 0:00 | ESPN+ |
 Appalachian State @ (10) Troy | 0:00 | ESPN+ |
| Saint Joseph's @ (FFO) Rhode Island | 5:00 PM | ESPN+ |
| (NFO) Davidson @ Saint Bonaventure | 5:00 PM | ESPN+ |
| (6) Maryland @ (3) Michigan State | 5:30 PM | |
| (10) Baylor @ Cincinnati | 5:30 PM | ESPN+ |
| (2) Nebraska @ (2) Michigan | 6:00 PM | |
| (NFO) Utah @ UCF | 6:00 PM | ESPN+ |
| Houston @ (2) TCU | 6:30 PM | ESPN+ |
| (10) BYU @ Kansas | 6:30 PM | ESPN+ |
| (NFO) Indiana @ Wisconsin | 6:30 PM | |
| (1) Connecticut @ DePaul | 7:00 PM | |
| (11) Richmond @ Saint Louis | 7:00 PM | ESPN+ |
| (7) Oklahoma State @ (11) Arizona State | 7:30 PM | |
| (8) Illinois @ (5) Oregon | 8:00 PM | |
| (6) West Virginia @ (FFO) Colorado | 8:00 PM | ESPN+ |
| Rutgers @ (1) UCLA | 9:00 PM | B1G+ |
February 5
| (3) Vanderbilt @ (4) Kentucky | 0:00 | |
| (9) Tennessee @ (9) Georgia | 0:00 | |
| (NFO) Clemson @ (5) North Carolina | 5:00 PM | ACC Network |
| (8) Stanford @ Pittsburgh | 5:00 PM | |
| (11) Syracuse @ Boston College | 5:00 PM | |
| (9) Mississippi State @ (1) South Carolina | 5:30 PM | SEC Network |
| (12) Southern Indiana @ Tennessee-Martin | 5:30 PM | ESPN+ |
| (5) Minnesota @ (3) Iowa | 6:00 PM | BTN |
| (6) Duke @ (4) Louisville | 6:00 PM | ESPN |
| (FFO) Virginia Tech @ (7) Notre Dame | 6:00 PM | |
| (11) Miami (FL) @ (11) Virginia | 6:00 PM | |
| Marist @ (11) Fairfield | 6:00 PM | ESPN+ |
| Auburn @ (FFO) Florida | 6:00 PM | |
| Florida State @ (7) North Carolina State | 7:00 PM | ACC Network |
| (12) North Dakota State @ UMKC | 7:00 PM | |
| (2) LSU @ (1) Texas | 8:00 PM | ESPN |
| (5) Ole Miss @ (7) Alabama | 8:00 PM | SEC Network |
| (6) USC @ Northwestern | 8:00 PM | BTN |
| (9) Ohio State @ (10) Washington | 8:00 PM | |
| (12) Santa Clara @ Pacific | 8:00 PM |
February 6
| Penn @ (8) Princeton | 6:00 PM | ESPN+ |
February 7
 Wyoming @ (12) Colorado State | 0:00 | |
| Butler @ (1) Connecticut | 11:00 AM | |
| (3) Michigan State @ Penn State | 12:00 PM | |
 Iona @ (11) Fairfield | 12:00 PM | ESPN+ |
| George Washington @ (NFO) Davidson | 12:00 PM | ESPN+ |
| (6) Maryland @ (2) Nebraska | 1:00 PM | BTN |
| Arizona @ (6) West Virginia | 1:00 PM | ESPN+ |
| UCF @ (7) Oklahoma State | 1:00 PM | |
| Georgetown @ (8) Villanova | 1:00 PM | ESPN+ |
| (12) North Dakota State @ Omaha | 1:00 PM | |
| (12) Southern Indiana @ Southeast Missouri | 1:30 PM | ESPN+ |
| (10) BYU @ Kansas State | 4:00 PM | ESPN+ |
| (3) Texas Tech @ Houston | 5:00 PM | ESPN+ |
| (11) Arizona State @ (10) Baylor | 5:00 PM | |
| George Mason @ (11) Richmond | 5:00 PM | ESPN+ |
| (4) Iowa State @ (NFO) Utah | 6:00 PM | ESPN+ |
February 8
| (4) Louisville @ (11) Syracuse | 11:00 AM | ACC Network |
| (5) Minnesota @ Rutgers | 11:00 AM | B1G+ |
| (7) North Carolina State @ (FFO) Virginia Tech | 11:00 AM | ACC Network |
| Saint Louis @ (FFO) Rhode Island | 11:00 AM | ESPN+ |
| (6) USC @ (8) Illinois | 12:00 PM | |
| Arkansas @ (FFO) Florida | 12:00 PM | SEC Network |
| (2) LSU @ Auburn | 1:00 PM | SEC Network |
| (5) North Carolina @ Wake Forest | 1:00 PM | ACC Network |
| SMU @ (6) Duke | 1:00 PM | |
| (7) Notre Dame @ (11) Virginia | 1:00 PM | |
| (8) Stanford @ Georgia Tech | 1:00 PM | |
| (11) Miami (FL) @ Florida State | 1:00 PM | |
| Purdue @ (NFO) Indiana | 1:00 PM | |
| Boston College @ (NFO) Clemson | 1:00 PM | |
| (9) Tennessee @ (1) South Carolina | 2:00 PM | ABC |
| (1) UCLA @ (2) Michigan | 2:00 PM | |
| (2) TCU @ (FFO) Colorado | 2:00 PM | ESPN+ |
| (10) Washington @ Wisconsin | 2:00 PM | |
| (9) Georgia @ Missouri | 3:00 PM | SEC Network |
| (7) Alabama @ Texas A&M | 5:00 PM | SEC Network |
| (9) Ohio State @ (5) Oregon | 8:00 PM |
February 9
| (4) Kentucky @ (1) Texas | 6:30 PM | SEC Network |
| (4) Oklahoma @ (3) Vanderbilt | 8:00 PM | ESPN2 |
February 10
| Kansas @ (3) Texas Tech | 6:00 PM | ESPN+ |
| (7) Oklahoma State @ Kansas State | 6:30 PM | ESPN+ |
| (4) Iowa State @ (10) BYU | 8:00 PM | ESPN+ |
February 11
| (8) Villanova @ Xavier | 0:00 | ESPN+ |
| Saint Bonaventure @ (11) Richmond | 5:00 PM | ESPN+ |
| VCU @ (FFO) Rhode Island | 5:00 PM | ESPN+ |
| Creighton @ (1) Connecticut | 6:00 PM | |
| UCF @ (6) West Virginia | 6:00 PM | ESPN+ |
| Wisconsin @ (8) Illinois | 6:00 PM | |
| (10) Washington @ (3) Iowa | 6:30 PM | |
| (FFO) Colorado @ Houston | 6:30 PM | ESPN+ |
| (1) UCLA @ (3) Michigan State | 7:00 PM | |
| (NFO) Utah @ (11) Arizona State | 7:30 PM | |
| (12) Colorado State @ San Diego State | 8:00 PM |
February 12
| (1) Texas @ (3) Vanderbilt | 0:00 | |
| (9) Georgia @ (9) Mississippi State | 0:00 | |
| Missouri @ (9) Tennessee | 0:00 | |
| Louisiana @ (10) Troy | 0:00 | ESPN+ |
| SMU @ (5) North Carolina | 5:00 PM | ACC Network |
| (11) Syracuse @ Pittsburgh | 5:00 PM | |
| Tennessee State @ (12) Southern Indiana | 5:00 PM | ESPN+ |
| Texas A&M @ (4) Kentucky | 5:30 PM | SEC Network |
| (2) TCU @ (10) Baylor | 6:00 PM | ESPN |
| Wake Forest @ (4) Louisville | 6:00 PM | |
| (FFO) Florida @ (4) Oklahoma | 6:00 PM | |
| Penn State @ (6) Maryland | 6:00 PM | |
(11) Fairfield @  Mount Saint Mary's | 6:00 PM | ESPN+ |
| (2) Nebraska @ (5) Minnesota | 7:00 PM | BTN |
| Georgia Tech @ (NFO) Clemson | 7:00 PM | ACC Network |
| (2) Michigan @ Northwestern | 8:00 PM | |
| Arkansas @ (5) Ole Miss | 8:00 PM | SEC Network |
(12) Santa Clara @  Oregon State | 8:00 PM | |
| (NFO) Indiana @ (6) USC | 9:00 PM | BTN |
| (FFO) Virginia Tech @ (8) Stanford | 9:00 PM | |
| (11) Virginia @ California | 9:00 PM |
February 13
| (8) Princeton @ Columbia | 5:00 PM | ESPNU |
February 14
| (8) Princeton @ Cornell | 0:00 | ESPN+ |
| ULM @ (10) Troy | 0:00 | ESPN+ |
| (12) Santa Clara @ Portland | 0:00 | |
| (12) Colorado State @ New Mexico | 0:00 | |
| (1) Connecticut @ Marquette | 12:00 PM | |
| (11) Arizona State @ Arizona | 12:00 PM | ESPN+ |
| (11) Richmond @ (NFO) Davidson | 12:00 PM | ESPN+ |
| Tennessee Tech @ (12) Southern Indiana | 1:00 PM | ESPN+ |
| (10) BYU @ (FFO) Colorado | 2:00 PM | ESPN+ |
| (FFO) Rhode Island @ George Mason | 2:00 PM | ESPN+ |
| (3) Texas Tech @ (7) Oklahoma State | 2:30 PM | |
| (11) Fairfield @ Quinnipiac | 3:09 PM | ESPN+ |
| Cincinnati @ (NFO) Utah | 6:00 PM | ESPN+ |
| (1) South Carolina @ (2) LSU | 7:30 PM | ABC |
February 15
| (7) North Carolina State @ (7) Notre Dame | 0:00 | ESPN |
| (3) Vanderbilt @ (9) Georgia | 11:00 AM | SEC Network |
| (11) Miami (FL) @ Boston College | 11:00 AM | |
| (5) North Carolina @ (6) Duke | 12:00 PM | ABC |
| (5) Ole Miss @ (4) Kentucky | 1:00 PM | SEC Network |
| Kansas State @ (4) Iowa State | 1:00 PM | ESPN |
| (6) Maryland @ (9) Ohio State | 1:00 PM | |
| (11) Virginia @ (8) Stanford | 1:00 PM | |
| (10) Baylor @ UCF | 1:00 PM | ESPN+ |
| (NFO) Clemson @ (11) Syracuse | 1:00 PM | |
(12) North Dakota State @  North Dakota | 1:00 PM | |
| (1) Texas @ (9) Tennessee | 2:00 PM | ABC |
| (NFO) Indiana @ (1) UCLA | 2:00 PM | Peacock |
| (3) Michigan State @ (2) Michigan | 3:00 PM | |
| (4) Oklahoma @ (7) Alabama | 3:00 PM | SEC Network |
| (5) Minnesota @ Wisconsin | 4:00 PM | BTN |
| (8) Villanova @ Creighton | 4:00 PM | |
| (FFO) Virginia Tech @ California | 4:00 PM | |
| Florida State @ (4) Louisville | 5:00 PM | ACC Network |
| (6) West Virginia @ (2) TCU | 7:00 PM | |
| (5) Oregon @ (10) Washington | 7:00 PM | BTN |
February 16
| (3) Iowa @ (2) Nebraska | 11:00 AM | |
| (NFO) Utah @ (7) Oklahoma State | 1:00 PM | |
| (9) Mississippi State @ Arkansas | 6:30 PM | SEC Network |
February 17
| Rutgers @ (8) Illinois | 6:00 PM | BTN |
| (FFO) Colorado @ Arizona | 7:00 PM | ESPN+ |
| Cincinnati @ (10) BYU | 8:00 PM | ESPN+ |
February 18
 South Alabama @ (10) Troy | 0:00 | ESPN+ |
| (11) Richmond @ George Washington | 5:00 PM | ESPN+ |
| (NFO) Davidson @ VCU | 5:00 PM | ESPN+ |
| Northwestern @ (3) Michigan State | 5:30 PM | |
| (FFO) Rhode Island @ La Salle | 5:30 PM | ESPN+ |
| (1) Connecticut @ (8) Villanova | 6:00 PM | ESPN+ |
| (10) Baylor @ (3) Texas Tech | 6:00 PM | ESPN+ |
| (2) TCU @ Houston | 6:30 PM | ESPN+ |
| (11) Arizona State @ (4) Iowa State | 6:30 PM | ESPN+ |
| (9) Ohio State @ (5) Minnesota | 7:00 PM | |
 Nevada @ (12) Colorado State | 8:30 PM |
February 19
| Saint Peter's @ (11) Fairfield | 0:00 | ESPN+ |
| Saint Mary's College @ (12) Santa Clara | 0:00 | |
| Saint Thomas @ (12) North Dakota State | 0:00 | |
| (5) North Carolina @ (FFO) Virginia Tech | 5:00 PM | ACC Network |
| (7) Notre Dame @ Wake Forest | 5:00 PM | |
| (12) Southern Indiana @ Western Illinois | 5:00 PM | ESPN+ |
| (4) Oklahoma @ (9) Georgia | 5:30 PM | SEC Network |
| Texas A&M @ (9) Tennessee | 5:30 PM | |
| (3) Iowa @ Purdue | 6:00 PM | |
| (7) North Carolina State @ (6) Duke | 6:00 PM | ESPN |
| (FFO) Florida @ (9) Mississippi State | 6:30 PM | |
| Wisconsin @ (6) USC | 7:00 PM | Peacock |
| (8) Stanford @ (11) Miami (FL) | 7:00 PM | ACC Network |
| (1) South Carolina @ (7) Alabama | 7:30 PM | SEC Network |
| (2) LSU @ (5) Ole Miss | 8:00 PM | ESPN |
| (2) Nebraska @ (5) Oregon | 8:00 PM | |
| (10) Washington @ (1) UCLA | 9:00 PM | BTN |
February 21
| (12) Santa Clara @ Pepperdine | 0:00 | |
| Fordham @ (FFO) Rhode Island | 12:00 PM | ESPN+ |
| Dayton @ (NFO) Davidson | 12:00 PM | ESPN+ |
| Southern Miss @ (10) Troy | 1:00 PM | ESPN+ |
| (11) Fairfield @ Siena | 1:00 PM | ESPN+ |
| (12) North Dakota State @ South Dakota | 1:00 PM | |
| (12) Southern Indiana @ Eastern Illinois | 1:00 PM | ESPN+ |
| (10) BYU @ (NFO) Utah | 3:00 PM | ESPN+ |
| Houston @ (11) Arizona State | 3:00 PM | |
| (12) Colorado State @ Wyoming | 3:00 PM | |
| Brown @ (8) Princeton | 4:30 PM | ESPN+ |
| Arizona @ (10) Baylor | 7:00 PM | ESPN+ |
| (3) Texas Tech @ (FFO) Colorado | 8:00 PM | ESPN+ |
February 22
| (2) Michigan @ (3) Iowa | 0:00 | |
| (4) Kentucky @ (3) Vanderbilt | 0:00 | |
| (6) USC @ (9) Ohio State | 0:00 | |
| Marquette @ (8) Villanova | 0:00 | ESPN+ |
| (5) Ole Miss @ (1) South Carolina | 11:00 AM | |
| Providence @ (1) Connecticut | 11:00 AM | |
| (11) Virginia @ (4) Louisville | 11:00 AM | |
| Pittsburgh @ (5) North Carolina | 11:00 AM | ACC Network |
| (7) Alabama @ (FFO) Florida | 11:00 AM | SEC Network |
| (5) Oregon @ (NFO) Indiana | 12:00 PM | BTN |
| Purdue @ (6) Maryland | 12:00 PM | |
| (9) Mississippi State @ (1) Texas | 1:00 PM | SEC Network |
| (9) Tennessee @ (4) Oklahoma | 1:00 PM | |
| (7) Oklahoma State @ (6) West Virginia | 1:00 PM | ESPN+ |
| (6) Duke @ (NFO) Clemson | 1:00 PM | |
| (11) Syracuse @ (7) North Carolina State | 1:00 PM | |
| (8) Stanford @ Florida State | 1:00 PM | ACC Network |
| La Salle @ (11) Richmond | 1:00 PM | ESPN+ |
| California @ (11) Miami (FL) | 1:00 PM | |
| Georgia Tech @ (FFO) Virginia Tech | 1:00 PM | |
| (2) Nebraska @ (10) Washington | 2:00 PM | BTN |
| (8) Illinois @ Northwestern | 2:00 PM | |
| Missouri @ (2) LSU | 3:00 PM | SEC Network |
| (4) Iowa State @ (2) TCU | 3:00 PM | ESPN |
| Wisconsin @ (1) UCLA | 4:30 PM | Peacock |
| (3) Michigan State @ (5) Minnesota | 5:00 PM | |
| (7) Notre Dame @ SMU | 5:00 PM | ACC Network |
February 23
| Kansas State @ (10) Baylor | 6:00 PM | ESPN2 |
| (9) Georgia @ Auburn | 6:30 PM | SEC Network |
February 24
(12) Southern Indiana @  Morehead State | 4:00 PM | ESPN+ |
| (10) Troy @ Arkansas State | 5:00 PM | ESPN+ |
| (NFO) Utah @ (FFO) Colorado | 8:00 PM | ESPN+ |
February 25
| UNLV @ (12) Colorado State | 0:00 | |
| (6) USC @ Penn State | 5:00 PM | |
| (FFO) Rhode Island @ (11) Richmond | 5:00 PM | ESPN+ |
| (NFO) Davidson @ Fordham | 5:00 PM | ESPN+ |
| (2) TCU @ Cincinnati | 5:30 PM | ESPN+ |
| Northwestern @ (6) Maryland | 5:30 PM | |
| (5) Oregon @ Purdue | 6:00 PM | |
| (6) West Virginia @ UCF | 6:00 PM | ESPN+ |
| (NFO) Indiana @ Rutgers | 6:00 PM | B1G+ |
| (3) Texas Tech @ Kansas | 6:30 PM | ESPN+ |
| (7) Oklahoma State @ (4) Iowa State | 6:30 PM | ESPN+ |
| (2) Michigan @ (9) Ohio State | 7:00 PM | |
| (10) BYU @ (11) Arizona State | 7:30 PM |
February 26
| (4) Kentucky @ Auburn | 0:00 | |
| Pacific @ (12) Santa Clara | 0:00 | |
| (9) Tennessee @ (2) LSU | 5:00 PM | ESPN |
| (5) Ole Miss @ (FFO) Florida | 5:00 PM | SEC Network |
| (4) Louisville @ Georgia Tech | 6:00 PM | ACC Network |
| Arkansas @ (4) Oklahoma | 6:00 PM | |
| (5) North Carolina @ (11) Virginia | 6:00 PM | |
| Wake Forest @ (7) North Carolina State | 6:00 PM | |
| (11) Syracuse @ (7) Notre Dame | 6:00 PM | |
| (8) Villanova @ Seton Hall | 6:00 PM | |
| Pittsburgh @ (11) Miami (FL) | 6:00 PM | |
| Georgetown @ (1) Connecticut | 6:30 PM | |
| (7) Alabama @ (3) Vanderbilt | 6:30 PM | |
| Missouri @ (1) South Carolina | 7:00 PM | SEC Network |
| Florida State @ (6) Duke | 7:00 PM | ACC Network |
| (9) Mississippi State @ Texas A&M | 7:00 PM | |
| South Dakota State @ (12) North Dakota State | 7:00 PM | |
| (8) Illinois @ (3) Iowa | 8:00 PM | BTN |
| (9) Georgia @ (1) Texas | 9:00 PM | SEC Network |
| SMU @ (8) Stanford | 9:00 PM | |
| (NFO) Clemson @ California | 9:00 PM |
February 27
| (8) Princeton @ Dartmouth | 5:00 PM | ESPN+ |
| (10) Troy @ South Alabama | 5:00 PM | ESPN+ |
February 28
| Rutgers @ (2) Nebraska | 0:00 | B1G+ |
| Sacred Heart @ (11) Fairfield | 0:00 | ESPN+ |
| Air Force @ (12) Colorado State | 0:00 | |
| Saint Louis @ (NFO) Davidson | 12:00 PM | ESPN+ |
| (11) Richmond @ Saint Joseph's | 1:00 PM | ESPN+ |
| North Dakota @ (12) North Dakota State | 1:00 PM | |
| Penn State @ (NFO) Indiana | 1:00 PM | |
(12) Southern Indiana @  Little Rock | 1:00 PM | ESPN+ |
| (6) Maryland @ (2) Michigan | 1:30 PM | |
| George Washington @ (FFO) Rhode Island | 1:30 PM | ESPN+ |
| San Francisco @ (12) Santa Clara | 2:00 PM | |
| (FFO) Colorado @ (10) BYU | 3:00 PM | ESPN+ |
| Kansas @ (7) Oklahoma State | 5:00 PM | |
| (8) Princeton @ Harvard | 6:00 PM | ESPN+ |
| Arizona @ (NFO) Utah | 6:00 PM | ESPN+ |
March 1
| (1) Connecticut @ Saint John's | 0:00 | |
| (10) Washington @ (5) Oregon | 0:00 | |
| (FFO) Florida @ (9) Georgia | 0:00 | |
| (1) Texas @ (7) Alabama | 11:00 AM | SEC Network |
| (9) Ohio State @ (3) Michigan State | 11:00 AM | BTN |
| (6) Duke @ (5) North Carolina | 11:00 AM | ESPN |
| (FFO) Virginia Tech @ (11) Virginia | 11:00 AM | ACC Network |
| (1) South Carolina @ (4) Kentucky | 1:00 PM | |
| (3) Vanderbilt @ (9) Tennessee | 1:00 PM | ESPN |
| (4) Iowa State @ Kansas State | 1:00 PM | |
| Cincinnati @ (6) West Virginia | 1:00 PM | ESPN+ |
| (7) North Carolina State @ Pittsburgh | 1:00 PM | ACC Network |
| (NFO) Clemson @ (8) Stanford | 1:00 PM | |
| Boston College @ (11) Syracuse | 1:00 PM | |
| (11) Miami (FL) @ Georgia Tech | 1:00 PM | |
| (3) Iowa @ Wisconsin | 2:00 PM | |
| (11) Arizona State @ (3) Texas Tech | 2:00 PM | ESPN+ |
| (4) Oklahoma @ Missouri | 2:00 PM | |
| (5) Minnesota @ (8) Illinois | 2:00 PM | |
| Texas A&M @ (5) Ole Miss | 2:00 PM | |
| (2) LSU @ (9) Mississippi State | 3:00 PM | SEC Network |
| (10) Baylor @ (2) TCU | 3:00 PM | ESPN |
| (7) Notre Dame @ (4) Louisville | 3:00 PM | ESPN2 |
| (1) UCLA @ (6) USC | 5:00 PM |
March 3
| (12) Colorado State @ San Jose State | 0:00 |
March 7
| Yale @ (8) Princeton | 1:00 PM | ESPN+ |