January 15
(3)  Louisville @ (7)  Notre Dame | 5:00 PM | ACC Network |
(7)  North Carolina State @  Wake Forest | 5:00 PM | ACC Extra |
(9)  Stanford @  Boston College | 5:00 PM | ACC Extra |
 California @ (10)  Syracuse | 5:00 PM | ACC Extra |
(2)  Vanderbilt @ (10)  Mississippi State | 5:30 PM | SEC Network |
(9)  Villanova @ (1)  Connecticut | 6:00 PM | FS1 |
(1)  Texas @ (1)  South Carolina | 6:00 PM | ESPN2 |
(8)  Illinois @ (2)  Michigan | 6:00 PM | Peacock |
(5)  Nebraska @ (2)  Michigan State | 6:00 PM | BTN |
 Florida @ (3)  Kentucky | 6:00 PM | SECN+ |
(11)  Miami (FL) @ (9)  North Carolina | 6:00 PM | ACC Extra |
(FFO)  Virginia Tech @  SMU | 6:30 PM | ACC Extra |
(FFO)  Virginia @ (5)  Duke | 7:00 PM | ACC Network |
 Denver @ (NFO)  South Dakota State | 7:00 PM | |
(7)  Oregon @ (3)  Iowa | 8:00 PM | FS1 |
(6)  Maryland @ (7)  USC | 8:00 PM | Peacock |
(6)  Alabama @  Auburn | 8:00 PM | SEC Network |
 Portland @ (12)  Santa Clara | 8:00 PM | ESPN+ |
January 17
(11)  Troy @  Texas State | 0:00 | ESPN+ |
 Manhattan @ (11)  Fairfield | 0:00 | ESPN+ |
 Montana @ (12)  Montana State | 0:00 | ESPN+ |
(12)  San Diego State @  UNLV | 0:00 | |
 Kansas State @ (4)  Texas Tech | 1:00 PM | ESPN+ |
 Dartmouth @ (8)  Princeton | 1:00 PM | ESPN+ |
(11)  Utah @  Houston | 1:00 PM | ESPN+ |
(NFO)  Seton Hall @  DePaul | 2:00 PM | ESPN+ |
(12)  North Dakota State @ (NFO) South Dakota State | 2:00 PM | |
(6)  Baylor @ (10)  BYU | 3:00 PM | ESPN+ |
 Kansas @ (10)  Arizona State | 3:00 PM | |
 Arizona @ (3)  TCU | 4:00 PM | ESPN+ |
(12) Santa Clara @  Saint Mary's College | 8:30 PM |
January 18
| (3) Kentucky @ (10) Mississippi State | 0:00 | |
 Butler @ (9) Villanova | 0:00 | ESPN+ |
(1) South Carolina @  Coppin State | 11:00 AM | ESPN+ |
(4)  Ole Miss @ (10)  Georgia | 11:00 AM | SEC Network |
 VCU @ (11)  Richmond | 11:00 AM | ESPN+ |
Wake Forest @ (FFO)  Clemson | 11:00 AM | ACC Network |
 Duquesne @ (FFO)  Rhode Island | 11:00 AM | |
| (3) Louisville @ (7) North Carolina State | 12:00 PM | ESPN2 |
(9)  Iowa State @ (8)  Oklahoma State | 12:00 PM | |
(5)  Tennessee @ (6) Alabama | 1:00 PM | SEC Network |
(5)  West Virginia @  Cincinnati | 1:00 PM | ESPN+ |
(9) North Carolina @  Florida State | 1:00 PM | |
| (9) Stanford @ (10) Syracuse | 1:00 PM | ACC Network |
(NFO)  Colorado @  UCF | 1:00 PM | ESPN+ |
(2)  LSU @ (4)  Oklahoma | 2:00 PM | |
(7) Oregon @  Wisconsin | 2:00 PM | BTN |
 Northwestern @ (8) Illinois | 2:00 PM | |
(6) Maryland @ (1)  UCLA | 3:00 PM | |
 Texas A&M @ (1) Texas | 3:00 PM | SEC Network |
 Purdue @ (7) USC | 4:00 PM | |
 Georgia Tech @ (5) Duke | 5:00 PM | ACC Network |
(6)  Minnesota @ (8)  Washington | 5:00 PM | BTN |
| (2) Michigan State @ (3) Iowa | 7:00 PM | BTN |
January 19
 Northern Colorado @ (12) Montana State | 0:00 | ESPN+ |
(3) TCU v. (4)  Ohio State | 11:00 AM | |
 Harvard @ (8) Princeton | 1:00 PM | ESPN+ |
 Siena @ (11) Fairfield | 1:00 PM | ESPN+ |
| (2) Michigan v. (2) Vanderbilt | 1:30 PM | |
| (7) Notre Dame @ (1) Connecticut | 4:00 PM |
January 20
 Providence @ (NFO) Seton Hall | 6:00 PM | ESPN+ |
January 21
 Davidson @ (FFO) Rhode Island | 5:00 PM | ESPN+ |
| (10) Arizona State @ (5) West Virginia | 6:00 PM | ESPN+ |
| (5) Nebraska @ Wisconsin | 6:30 PM | |
| Cincinnati @ (9) Iowa State | 6:30 PM | ESPN+ |
| UCF @ (6) Baylor | 7:00 PM | ESPN+ |
(12) North Dakota State @  Saint Thomas | 7:00 PM | |
(NFO) South Dakota State @  North Dakota | 7:00 PM | |
| (4) Texas Tech @ (10) BYU | 8:00 PM | ESPN+ |
| (6) Minnesota @ (7) Oregon | 8:00 PM | |
 Penn State @ (8) Washington | 8:00 PM | |
| Purdue @ (1) UCLA | 9:00 PM |
January 22
| Auburn @ (2) Vanderbilt | 0:00 | |
(4) Ole Miss @  Missouri | 0:00 | |
(11) Fairfield @  Niagara | 0:00 | ESPN+ |
(12) Santa Clara @  Seattle University | 0:00 | |
(2) Michigan @  Rutgers | 5:00 PM | BTN |
| (3) Iowa @ (6) Maryland | 5:00 PM | |
| (11) Miami (FL) @ (7) Notre Dame | 5:00 PM | ACC Network |
| (FFO) Clemson @ (FFO) Virginia Tech | 5:00 PM | |
| (3) Kentucky @ (5) Tennessee | 5:30 PM | SEC Network |
| (1) South Carolina @ (4) Oklahoma | 6:00 PM | ESPN |
 Pittsburgh @ (FFO) Virginia | 6:00 PM | |
 Georgia Southern @ (11) Troy | 6:00 PM | ESPN+ |
(1) Connecticut v.  Georgetown | 6:30 PM | |
(10) Georgia @  Arkansas | 6:30 PM | |
| (7) USC @ (2) Michigan State | 7:00 PM | BTN |
(NFO)  Indiana @ (4) Ohio State | 7:00 PM | Peacock |
| (9) North Carolina @ Georgia Tech | 7:00 PM | ACC Network |
| (2) LSU @ Texas A&M | 8:00 PM | SEC Network |
(12) Montana State @  Idaho State | 8:00 PM | ESPN+ |
January 24
(9) Villanova @  Saint John's | 0:00 | |
 Georgia State @ (11) Troy | 0:00 | ESPN+ |
 South Dakota @ (12) North Dakota State | 0:00 | |
(8) Princeton @  Brown | 11:00 AM | ESPN+ |
(11) Fairfield @  Canisius | 12:00 PM | ESPN+ |
| (3) TCU @ UCF | 1:00 PM | ESPN+ |
| (8) Illinois @ (5) Nebraska | 1:00 PM | BTN |
| (10) Arizona State @ Cincinnati | 1:00 PM | ESPN+ |
(NFO) South Dakota State @  UMKC | 2:00 PM | |
| Arizona @ (9) Iowa State | 3:00 PM | |
(12) Montana State @  Weber State | 3:00 PM | ESPN+ |
 San Jose State @ (12) San Diego State | 3:00 PM | |
| Penn State @ (7) Oregon | 4:00 PM | |
| (4) Texas Tech @ (11) Utah | 6:00 PM | ESPN+ |
| (5) West Virginia @ (10) BYU | 8:30 PM | ESPN+ |
January 25
| (NFO) Indiana @ Purdue | 0:00 | |
| (1) Connecticut @ (NFO) Seton Hall | 11:00 AM | |
| (10) Georgia @ (3) Kentucky | 11:00 AM | SEC Network |
| (7) North Carolina State @ (FFO) Virginia | 11:00 AM | ACC Network |
| (7) USC @ (2) Michigan | 1:00 PM | BTN |
| Boston College @ (3) Louisville | 1:00 PM | |
| (4) Ohio State @ (3) Iowa | 1:00 PM | |
| (4) Oklahoma @ Auburn | 1:00 PM | SEC Network |
| (5) Duke @ Pittsburgh | 1:00 PM | ACC Network |
| (8) Washington @ Rutgers | 1:00 PM | B1G+ |
| (10) Syracuse @ (9) North Carolina | 1:00 PM | |
(11) Richmond @  George Mason | 1:00 PM | ESPNU |
(FFO) Rhode Island @  Dayton | 1:00 PM | ESPN+ |
| (FFO) Virginia Tech @ Wake Forest | 1:00 PM | |
| (2) Vanderbilt @ (1) South Carolina | 2:00 PM | ESPN |
| (10) Mississippi State @ (6) Alabama | 2:00 PM | |
| Houston @ (6) Baylor | 2:00 PM | ESPN+ |
| Wisconsin @ (6) Minnesota | 2:00 PM | |
| (FFO) Clemson @ (7) Notre Dame | 2:00 PM | |
| (8) Oklahoma State @ (NFO) Colorado | 2:00 PM | ESPN+ |
| (1) UCLA @ Northwestern | 3:00 PM | BTN |
| (1) Texas @ Arkansas | 3:00 PM | SEC Network |
| (11) Miami (FL) @ SMU | 3:00 PM | |
| (9) Stanford @ California | 5:00 PM | ACC Network |
January 26
| (5) Tennessee @ (4) Ole Miss | 6:00 PM | ESPNU |
| Florida @ (2) LSU | 7:00 PM | SEC Network |
January 27
| Providence @ (9) Villanova | 6:00 PM | ESPN+ |
| (5) West Virginia @ (11) Utah | 8:00 PM | ESPN+ |
January 28
(12) San Diego State @  Colorado State | 0:00 | |
| (6) Minnesota @ Penn State | 5:00 PM | |
| Duquesne @ (11) Richmond | 5:00 PM | ESPN+ |
(11) Troy @  Marshall | 5:00 PM | ESPN+ |
| (1) UCLA @ (8) Illinois | 6:00 PM | |
| (9) Iowa State @ (4) Texas Tech | 6:00 PM | ESPN+ |
| (8) Washington @ (6) Maryland | 6:00 PM | |
| (7) Oregon @ Rutgers | 6:00 PM | B1G+ |
| (10) BYU @ (8) Oklahoma State | 6:30 PM | |
 Xavier @ (1) Connecticut | 7:00 PM | |
| Northwestern @ (5) Nebraska | 7:00 PM | |
 Omaha @ (NFO) South Dakota State | 7:00 PM | |
| Arizona @ (10) Arizona State | 7:30 PM |
January 29
| (2) Vanderbilt @ (4) Ole Miss | 0:00 | |
| (10) Mississippi State @ (5) Tennessee | 0:00 | |
| Denver @ (12) North Dakota State | 0:00 | |
 Sacramento State @ (12) Montana State | 0:00 | ESPN+ |
| (NFO) Seton Hall @ Georgetown | 10:00 AM | ESPN+ |
| (2) Michigan State @ Purdue | 5:00 PM | BTN |
| Kansas @ (3) TCU | 5:00 PM | ESPN |
| (7) North Carolina State @ Boston College | 5:00 PM | ACC Network |
| Georgia Tech @ (10) Syracuse | 5:00 PM | |
| (FFO) Virginia @ Wake Forest | 5:00 PM | |
| Pittsburgh @ (FFO) Virginia Tech | 5:00 PM | |
| (6) Alabama @ (10) Georgia | 5:30 PM | SEC Network |
| (1) Texas @ Florida | 6:00 PM | |
| (2) Michigan @ (NFO) Indiana | 6:00 PM | Peacock |
| Texas A&M @ (4) Oklahoma | 6:00 PM | |
| Wisconsin @ (4) Ohio State | 6:00 PM | BTN |
| SMU @ (FFO) Clemson | 6:00 PM | |
 Quinnipiac @ (11) Fairfield | 6:00 PM | ESPN+ |
| (NFO) Colorado @ Kansas State | 6:30 PM | ESPN+ |
| Arkansas @ (2) LSU | 7:00 PM | |
| (3) Louisville @ (9) Stanford | 7:00 PM | ESPN |
| (5) Duke @ (11) Miami (FL) | 7:00 PM | ACC Network |
| (1) South Carolina @ Auburn | 8:00 PM | SEC Network |
| (3) Iowa @ (7) USC | 8:00 PM | |
 Washington State @ (12) Santa Clara | 8:00 PM | |
| (7) Notre Dame @ California | 9:00 PM |
January 30
 Columbia @ (8) Princeton | 5:00 PM | ESPNU |
January 31
| (7) Oregon @ (6) Maryland | 0:00 | BTN |
| DePaul @ (9) Villanova | 0:00 | ESPN+ |
(11) Troy @  Coastal Carolina | 0:00 | ESPN+ |
 Oral Roberts @ (12) North Dakota State | 0:00 | |
 Pepperdine @ (12) Santa Clara | 0:00 | |
| UCF @ (9) Iowa State | 1:00 PM | ESPN+ |
(FFO) Rhode Island @  Fordham | 1:00 PM | ESPN+ |
(11) Fairfield @  Sacred Heart | 1:00 PM | ESPN+ |
| (NFO) South Dakota State @ South Dakota | 1:00 PM | |
| (11) Utah @ (10) BYU | 3:00 PM | ESPN+ |
 Portland State @ (12) Montana State | 3:00 PM | ESPN+ |
 Nevada @ (12) San Diego State | 3:00 PM | |
 Cornell @ (8) Princeton | 4:00 PM | ESPN+ |
February 1
| Auburn @ (4) Ole Miss | 0:00 | |
| Missouri @ (10) Mississippi State | 0:00 | |
| (5) Tennessee @ (1) Connecticut | 11:00 AM | |
| (6) Alabama @ (2) LSU | 11:00 AM | SEC Network |
| (2) Michigan @ (2) Michigan State | 11:00 AM | |
| Wake Forest @ (5) Duke | 11:00 AM | ACC Network |
| (6) Baylor @ (5) West Virginia | 11:00 AM | ESPN |
| (11) Richmond @ VCU | 11:00 AM | ESPNU |
| (3) Louisville @ California | 12:00 PM | |
| (3) TCU @ (4) Texas Tech | 1:00 PM | |
| (3) Kentucky @ Arkansas | 1:00 PM | SEC Network |
| (10) Syracuse @ (11) Miami (FL) | 1:00 PM | |
| (FFO) Virginia @ (FFO) Virginia Tech | 1:00 PM | |
| Northwestern @ (NFO) Indiana | 1:00 PM | |
| (4) Oklahoma @ (1) Texas | 2:00 PM | ABC |
| Purdue @ (6) Minnesota | 2:00 PM | |
 Creighton @ (NFO) Seton Hall | 2:00 PM | |
| (NFO) Colorado @ Kansas | 2:00 PM | ESPN+ |
| (3) Iowa @ (1) UCLA | 3:00 PM | |
| Florida @ (2) Vanderbilt | 3:00 PM | SEC Network |
| (7) Notre Dame @ (9) Stanford | 3:00 PM | |
| (8) Oklahoma State @ Arizona | 3:00 PM | ESPN+ |
| Kansas State @ (10) Arizona State | 3:00 PM | |
| Rutgers @ (7) USC | 4:00 PM | B1G+ |
| (5) Nebraska @ (4) Ohio State | 5:00 PM | BTN |
| (8) Illinois @ (8) Washington | 5:00 PM | FS1 |
| Florida State @ (FFO) Clemson | 5:00 PM | ACC Network |
February 2
| (9) North Carolina @ (7) North Carolina State | 5:00 PM | ESPN2 |
| (1) South Carolina @ Texas A&M | 7:00 PM |
February 4
| (9) Villanova @ Butler | 0:00 | ESPN+ |
 Appalachian State @ (11) Troy | 0:00 | ESPN+ |
(12) San Diego State @  Grand Canyon | 0:00 | |
 Saint Joseph's @ (FFO) Rhode Island | 5:00 PM | ESPN+ |
| (6) Maryland @ (2) Michigan State | 5:30 PM | |
| (6) Baylor @ Cincinnati | 5:30 PM | ESPN+ |
| (5) Nebraska @ (2) Michigan | 6:00 PM | |
| (11) Utah @ UCF | 6:00 PM | ESPN+ |
| Houston @ (3) TCU | 6:30 PM | ESPN+ |
| (10) BYU @ Kansas | 6:30 PM | ESPN+ |
| (NFO) Indiana @ Wisconsin | 6:30 PM | |
| (1) Connecticut @ DePaul | 7:00 PM | |
(11) Richmond @  Saint Louis | 7:00 PM | ESPN+ |
| (8) Oklahoma State @ (10) Arizona State | 7:30 PM | |
| (5) West Virginia @ (NFO) Colorado | 8:00 PM | ESPN+ |
| (8) Illinois @ (7) Oregon | 8:00 PM | |
| (NFO) South Dakota State @ Saint Thomas | 8:00 PM | |
| Rutgers @ (1) UCLA | 9:00 PM | B1G+ |
February 5
| (2) Vanderbilt @ (3) Kentucky | 0:00 | |
| (5) Tennessee @ (10) Georgia | 0:00 | |
| (FFO) Clemson @ (9) North Carolina | 5:00 PM | ACC Network |
| (9) Stanford @ Pittsburgh | 5:00 PM | |
| (10) Syracuse @ Boston College | 5:00 PM | |
| (10) Mississippi State @ (1) South Carolina | 5:30 PM | SEC Network |
| (5) Duke @ (3) Louisville | 6:00 PM | ESPN |
| (6) Minnesota @ (3) Iowa | 6:00 PM | BTN |
| (FFO) Virginia Tech @ (7) Notre Dame | 6:00 PM | |
| (11) Miami (FL) @ (FFO) Virginia | 6:00 PM | |
 Marist @ (11) Fairfield | 6:00 PM | ESPN+ |
| Florida State @ (7) North Carolina State | 7:00 PM | ACC Network |
| (12) North Dakota State @ UMKC | 7:00 PM | |
| (2) LSU @ (1) Texas | 8:00 PM | ESPN |
| (4) Ole Miss @ (6) Alabama | 8:00 PM | SEC Network |
| (4) Ohio State @ (8) Washington | 8:00 PM | |
| (7) USC @ Northwestern | 8:00 PM | BTN |
(12) Santa Clara @  Pacific | 8:00 PM | |
(12) Montana State @  Idaho | 8:00 PM | ESPN+ |
February 6
 Penn @ (8) Princeton | 6:00 PM | ESPN+ |
February 7
| (12) San Diego State @ San Jose State | 0:00 | |
| Butler @ (1) Connecticut | 11:00 AM | |
| (2) Michigan State @ Penn State | 12:00 PM | |
 Iona @ (11) Fairfield | 12:00 PM | ESPN+ |
| Arizona @ (5) West Virginia | 1:00 PM | ESPN+ |
| (6) Maryland @ (5) Nebraska | 1:00 PM | BTN |
| UCF @ (8) Oklahoma State | 1:00 PM | |
| Georgetown @ (9) Villanova | 1:00 PM | ESPN+ |
| (NFO) Seton Hall @ Saint John's | 1:00 PM | ESPN+ |
| (12) North Dakota State @ Omaha | 1:00 PM | |
| (10) BYU @ Kansas State | 4:00 PM | ESPN+ |
(12) Montana State @  Eastern Washington | 4:00 PM | ESPN+ |
| (4) Texas Tech @ Houston | 5:00 PM | ESPN+ |
| (10) Arizona State @ (6) Baylor | 5:00 PM | |
| George Mason @ (11) Richmond | 5:00 PM | ESPN+ |
| (9) Iowa State @ (11) Utah | 6:00 PM | ESPN+ |
February 8
| (3) Louisville @ (10) Syracuse | 11:00 AM | ACC Network |
| (6) Minnesota @ Rutgers | 11:00 AM | B1G+ |
| (7) North Carolina State @ (FFO) Virginia Tech | 11:00 AM | ACC Network |
| Saint Louis @ (FFO) Rhode Island | 11:00 AM | ESPN+ |
| (7) USC @ (8) Illinois | 12:00 PM | |
| (2) LSU @ Auburn | 1:00 PM | SEC Network |
| SMU @ (5) Duke | 1:00 PM | |
| (7) Notre Dame @ (FFO) Virginia | 1:00 PM | |
| (9) North Carolina @ Wake Forest | 1:00 PM | ACC Network |
| (9) Stanford @ Georgia Tech | 1:00 PM | |
| (11) Miami (FL) @ Florida State | 1:00 PM | |
| Boston College @ (FFO) Clemson | 1:00 PM | |
| Purdue @ (NFO) Indiana | 1:00 PM | |
| (1) UCLA @ (2) Michigan | 2:00 PM | |
| (5) Tennessee @ (1) South Carolina | 2:00 PM | ABC |
| (3) TCU @ (NFO) Colorado | 2:00 PM | ESPN+ |
| (8) Washington @ Wisconsin | 2:00 PM | |
| (10) Georgia @ Missouri | 3:00 PM | SEC Network |
| (6) Alabama @ Texas A&M | 5:00 PM | SEC Network |
| (4) Ohio State @ (7) Oregon | 8:00 PM |
February 9
| (3) Kentucky @ (1) Texas | 6:30 PM | SEC Network |
| (4) Oklahoma @ (2) Vanderbilt | 8:00 PM | ESPN2 |
February 10
| Kansas @ (4) Texas Tech | 6:00 PM | ESPN+ |
| (8) Oklahoma State @ Kansas State | 6:30 PM | ESPN+ |
| (9) Iowa State @ (10) BYU | 8:00 PM | ESPN+ |
February 11
| (9) Villanova @ Xavier | 0:00 | ESPN+ |
 Saint Bonaventure @ (11) Richmond | 5:00 PM | ESPN+ |
| VCU @ (FFO) Rhode Island | 5:00 PM | ESPN+ |
| Creighton @ (1) Connecticut | 6:00 PM | |
| UCF @ (5) West Virginia | 6:00 PM | ESPN+ |
| Wisconsin @ (8) Illinois | 6:00 PM | |
| (8) Washington @ (3) Iowa | 6:30 PM | |
(NFO) Seton Hall @  Marquette | 6:30 PM | ESPN+ |
| (NFO) Colorado @ Houston | 6:30 PM | ESPN+ |
| (1) UCLA @ (2) Michigan State | 7:00 PM | |
| (11) Utah @ (10) Arizona State | 7:30 PM | |
| Colorado State @ (12) San Diego State | 8:00 PM |
February 12
| (1) Texas @ (2) Vanderbilt | 0:00 | |
| Missouri @ (5) Tennessee | 0:00 | |
| (10) Georgia @ (10) Mississippi State | 0:00 | |
 Louisiana @ (11) Troy | 0:00 | ESPN+ |
| SMU @ (9) North Carolina | 5:00 PM | ACC Network |
| (10) Syracuse @ Pittsburgh | 5:00 PM | |
| Texas A&M @ (3) Kentucky | 5:30 PM | SEC Network |
| (3) TCU @ (6) Baylor | 6:00 PM | ESPN |
| Wake Forest @ (3) Louisville | 6:00 PM | |
| Florida @ (4) Oklahoma | 6:00 PM | |
| Penn State @ (6) Maryland | 6:00 PM | |
(11) Fairfield @  Mount Saint Mary's | 6:00 PM | ESPN+ |
| (5) Nebraska @ (6) Minnesota | 7:00 PM | BTN |
| Georgia Tech @ (FFO) Clemson | 7:00 PM | ACC Network |
| North Dakota @ (NFO) South Dakota State | 7:00 PM | |
| (2) Michigan @ Northwestern | 8:00 PM | |
| Arkansas @ (4) Ole Miss | 8:00 PM | SEC Network |
(12) Santa Clara @  Oregon State | 8:00 PM | |
| (NFO) Indiana @ (7) USC | 9:00 PM | BTN |
| (FFO) Virginia Tech @ (9) Stanford | 9:00 PM | |
| (FFO) Virginia @ California | 9:00 PM |
February 13
| (8) Princeton @ Columbia | 5:00 PM | ESPNU |
February 14
| (8) Princeton @ Cornell | 0:00 | ESPN+ |
 ULM @ (11) Troy | 0:00 | ESPN+ |
| (12) Santa Clara @ Portland | 0:00 | |
| (12) Montana State @ Montana | 0:00 | ESPN+ |
| (1) Connecticut @ Marquette | 12:00 PM | |
| (10) Arizona State @ Arizona | 12:00 PM | ESPN+ |
| (11) Richmond @ Davidson | 12:00 PM | ESPN+ |
| DePaul @ (NFO) Seton Hall | 12:00 PM | ESPN+ |
| (10) BYU @ (NFO) Colorado | 2:00 PM | ESPN+ |
| (FFO) Rhode Island @ George Mason | 2:00 PM | ESPN+ |
| UMKC @ (NFO) South Dakota State | 2:00 PM | |
| (4) Texas Tech @ (8) Oklahoma State | 2:30 PM | |
| (12) San Diego State @ Nevada | 3:00 PM | |
| (11) Fairfield @ Quinnipiac | 3:09 PM | ESPN+ |
| Cincinnati @ (11) Utah | 6:00 PM | ESPN+ |
| (1) South Carolina @ (2) LSU | 7:30 PM | ABC |
February 15
| (7) North Carolina State @ (7) Notre Dame | 0:00 | ESPN |
| (2) Vanderbilt @ (10) Georgia | 11:00 AM | SEC Network |
| (11) Miami (FL) @ Boston College | 11:00 AM | |
| (9) North Carolina @ (5) Duke | 12:00 PM | ABC |
| (4) Ole Miss @ (3) Kentucky | 1:00 PM | SEC Network |
| (6) Maryland @ (4) Ohio State | 1:00 PM | |
| (6) Baylor @ UCF | 1:00 PM | ESPN+ |
| (FFO) Virginia @ (9) Stanford | 1:00 PM | |
| Kansas State @ (9) Iowa State | 1:00 PM | ESPN |
| (FFO) Clemson @ (10) Syracuse | 1:00 PM | |
| (12) North Dakota State @ North Dakota | 1:00 PM | |
| (NFO) Indiana @ (1) UCLA | 2:00 PM | Peacock |
| (1) Texas @ (5) Tennessee | 2:00 PM | ABC |
| (2) Michigan State @ (2) Michigan | 3:00 PM | |
| (4) Oklahoma @ (6) Alabama | 3:00 PM | SEC Network |
| (6) Minnesota @ Wisconsin | 4:00 PM | BTN |
| (9) Villanova @ Creighton | 4:00 PM | |
| (FFO) Virginia Tech @ California | 4:00 PM | |
| Florida State @ (3) Louisville | 5:00 PM | ACC Network |
| (5) West Virginia @ (3) TCU | 7:00 PM | |
| (7) Oregon @ (8) Washington | 7:00 PM | BTN |
February 16
| (3) Iowa @ (5) Nebraska | 11:00 AM | |
| (11) Utah @ (8) Oklahoma State | 1:00 PM | |
| (10) Mississippi State @ Arkansas | 6:30 PM | SEC Network |
February 17
| Rutgers @ (8) Illinois | 6:00 PM | BTN |
| (NFO) Colorado @ Arizona | 7:00 PM | ESPN+ |
| Cincinnati @ (10) BYU | 8:00 PM | ESPN+ |
February 18
 South Alabama @ (11) Troy | 0:00 | ESPN+ |
(11) Richmond @  George Washington | 5:00 PM | ESPN+ |
| Northwestern @ (2) Michigan State | 5:30 PM | |
(FFO) Rhode Island @  La Salle | 5:30 PM | ESPN+ |
| (NFO) Seton Hall @ Xavier | 5:30 PM | ESPN+ |
| (1) Connecticut @ (9) Villanova | 6:00 PM | ESPN+ |
| (6) Baylor @ (4) Texas Tech | 6:00 PM | ESPN+ |
| (3) TCU @ Houston | 6:30 PM | ESPN+ |
| (10) Arizona State @ (9) Iowa State | 6:30 PM | ESPN+ |
| (4) Ohio State @ (6) Minnesota | 7:00 PM | |
| UNLV @ (12) San Diego State | 8:00 PM |
February 19
 Saint Peter's @ (11) Fairfield | 0:00 | ESPN+ |
| Saint Thomas @ (12) North Dakota State | 0:00 | |
| Saint Mary's College @ (12) Santa Clara | 0:00 | |
| (7) Notre Dame @ Wake Forest | 5:00 PM | |
| (9) North Carolina @ (FFO) Virginia Tech | 5:00 PM | ACC Network |
| (4) Oklahoma @ (10) Georgia | 5:30 PM | SEC Network |
| Texas A&M @ (5) Tennessee | 5:30 PM | |
| (3) Iowa @ Purdue | 6:00 PM | |
| (7) North Carolina State @ (5) Duke | 6:00 PM | ESPN |
| Florida @ (10) Mississippi State | 6:30 PM | |
| Wisconsin @ (7) USC | 7:00 PM | Peacock |
| (9) Stanford @ (11) Miami (FL) | 7:00 PM | ACC Network |
| (NFO) South Dakota State @ Oral Roberts | 7:00 PM | |
| Weber State @ (12) Montana State | 7:00 PM | ESPN+ |
| (1) South Carolina @ (6) Alabama | 7:30 PM | SEC Network |
| (2) LSU @ (4) Ole Miss | 8:00 PM | ESPN |
| (5) Nebraska @ (7) Oregon | 8:00 PM | |
| (8) Washington @ (1) UCLA | 9:00 PM | BTN |
February 21
| (12) Santa Clara @ Pepperdine | 0:00 | |
| Fordham @ (FFO) Rhode Island | 12:00 PM | ESPN+ |
 Southern Miss @ (11) Troy | 1:00 PM | ESPN+ |
| (11) Fairfield @ Siena | 1:00 PM | ESPN+ |
| (12) North Dakota State @ South Dakota | 1:00 PM | |
| (NFO) South Dakota State @ Denver | 2:00 PM | |
| Houston @ (10) Arizona State | 3:00 PM | |
| (10) BYU @ (11) Utah | 3:00 PM | ESPN+ |
| Idaho State @ (12) Montana State | 3:00 PM | ESPN+ |
 Fresno State @ (12) San Diego State | 3:00 PM | |
| Brown @ (8) Princeton | 4:30 PM | ESPN+ |
| Arizona @ (6) Baylor | 7:00 PM | ESPN+ |
| (4) Texas Tech @ (NFO) Colorado | 8:00 PM | ESPN+ |
February 22
| (2) Michigan @ (3) Iowa | 0:00 | |
| (3) Kentucky @ (2) Vanderbilt | 0:00 | |
| (7) USC @ (4) Ohio State | 0:00 | |
| Marquette @ (9) Villanova | 0:00 | ESPN+ |
| Providence @ (1) Connecticut | 11:00 AM | |
| (4) Ole Miss @ (1) South Carolina | 11:00 AM | |
| (FFO) Virginia @ (3) Louisville | 11:00 AM | |
| (6) Alabama @ Florida | 11:00 AM | SEC Network |
| Pittsburgh @ (9) North Carolina | 11:00 AM | ACC Network |
| Purdue @ (6) Maryland | 12:00 PM | |
| (7) Oregon @ (NFO) Indiana | 12:00 PM | BTN |
| Saint John's @ (NFO) Seton Hall | 12:00 PM | ESPN+ |
| (10) Mississippi State @ (1) Texas | 1:00 PM | SEC Network |
| (5) Tennessee @ (4) Oklahoma | 1:00 PM | |
| (5) Duke @ (FFO) Clemson | 1:00 PM | |
| (8) Oklahoma State @ (5) West Virginia | 1:00 PM | ESPN+ |
| (10) Syracuse @ (7) North Carolina State | 1:00 PM | |
| (9) Stanford @ Florida State | 1:00 PM | ACC Network |
| California @ (11) Miami (FL) | 1:00 PM | |
| La Salle @ (11) Richmond | 1:00 PM | ESPN+ |
| Georgia Tech @ (FFO) Virginia Tech | 1:00 PM | |
| (5) Nebraska @ (8) Washington | 2:00 PM | BTN |
| (8) Illinois @ Northwestern | 2:00 PM | |
| Missouri @ (2) LSU | 3:00 PM | SEC Network |
| (9) Iowa State @ (3) TCU | 3:00 PM | ESPN |
| Wisconsin @ (1) UCLA | 4:30 PM | Peacock |
| (2) Michigan State @ (6) Minnesota | 5:00 PM | |
| (7) Notre Dame @ SMU | 5:00 PM | ACC Network |
February 23
| Kansas State @ (6) Baylor | 6:00 PM | ESPN2 |
| (10) Georgia @ Auburn | 6:30 PM | SEC Network |
February 24
(11) Troy @  Arkansas State | 5:00 PM | ESPN+ |
| (11) Utah @ (NFO) Colorado | 8:00 PM | ESPN+ |
February 25
(12) San Diego State @  Boise State | 0:00 | |
| (7) USC @ Penn State | 5:00 PM | |
| (FFO) Rhode Island @ (11) Richmond | 5:00 PM | ESPN+ |
| (3) TCU @ Cincinnati | 5:30 PM | ESPN+ |
| Northwestern @ (6) Maryland | 5:30 PM | |
| (5) West Virginia @ UCF | 6:00 PM | ESPN+ |
| (7) Oregon @ Purdue | 6:00 PM | |
| (NFO) Indiana @ Rutgers | 6:00 PM | B1G+ |
| (4) Texas Tech @ Kansas | 6:30 PM | ESPN+ |
| (8) Oklahoma State @ (9) Iowa State | 6:30 PM | ESPN+ |
| (2) Michigan @ (4) Ohio State | 7:00 PM | |
| (10) BYU @ (10) Arizona State | 7:30 PM |
February 26
| (3) Kentucky @ Auburn | 0:00 | |
| Pacific @ (12) Santa Clara | 0:00 | |
| (5) Tennessee @ (2) LSU | 5:00 PM | ESPN |
| (4) Ole Miss @ Florida | 5:00 PM | SEC Network |
| (3) Louisville @ Georgia Tech | 6:00 PM | ACC Network |
| Arkansas @ (4) Oklahoma | 6:00 PM | |
| Wake Forest @ (7) North Carolina State | 6:00 PM | |
| (10) Syracuse @ (7) Notre Dame | 6:00 PM | |
| (9) North Carolina @ (FFO) Virginia | 6:00 PM | |
| (9) Villanova @ (NFO) Seton Hall | 6:00 PM | |
| Pittsburgh @ (11) Miami (FL) | 6:00 PM | |
| Georgetown @ (1) Connecticut | 6:30 PM | |
| (6) Alabama @ (2) Vanderbilt | 6:30 PM | |
| Missouri @ (1) South Carolina | 7:00 PM | SEC Network |
| Florida State @ (5) Duke | 7:00 PM | ACC Network |
| (10) Mississippi State @ Texas A&M | 7:00 PM | |
| (NFO) South Dakota State @ (12) North Dakota State | 7:00 PM | |
| (8) Illinois @ (3) Iowa | 8:00 PM | BTN |
| (10) Georgia @ (1) Texas | 9:00 PM | SEC Network |
| SMU @ (9) Stanford | 9:00 PM | |
| (FFO) Clemson @ California | 9:00 PM | |
| (12) Montana State @ Portland State | 9:00 PM | ESPN+ |
February 27
| (8) Princeton @ Dartmouth | 5:00 PM | ESPN+ |
| (11) Troy @ South Alabama | 5:00 PM | ESPN+ |
February 28
| Rutgers @ (5) Nebraska | 0:00 | B1G+ |
| Sacred Heart @ (11) Fairfield | 0:00 | ESPN+ |
| (11) Richmond @ Saint Joseph's | 1:00 PM | ESPN+ |
| North Dakota @ (12) North Dakota State | 1:00 PM | |
| Penn State @ (NFO) Indiana | 1:00 PM | |
| (6) Maryland @ (2) Michigan | 1:30 PM | |
| George Washington @ (FFO) Rhode Island | 1:30 PM | ESPN+ |
 San Francisco @ (12) Santa Clara | 2:00 PM | |
| (NFO) Colorado @ (10) BYU | 3:00 PM | ESPN+ |
 Wyoming @ (12) San Diego State | 3:00 PM | |
| (12) Montana State @ Sacramento State | 4:00 PM | ESPN+ |
| Kansas @ (8) Oklahoma State | 5:00 PM | |
| (8) Princeton @ Harvard | 6:00 PM | ESPN+ |
| Arizona @ (11) Utah | 6:00 PM | ESPN+ |
| South Dakota @ (NFO) South Dakota State | 6:00 PM |
March 1
| (1) Connecticut @ Saint John's | 0:00 | |
| (8) Washington @ (7) Oregon | 0:00 | |
| Florida @ (10) Georgia | 0:00 | |
| (1) Texas @ (6) Alabama | 11:00 AM | SEC Network |
| (4) Ohio State @ (2) Michigan State | 11:00 AM | BTN |
| (5) Duke @ (9) North Carolina | 11:00 AM | ESPN |
| (FFO) Virginia Tech @ (FFO) Virginia | 11:00 AM | ACC Network |
| (1) South Carolina @ (3) Kentucky | 1:00 PM | |
| (2) Vanderbilt @ (5) Tennessee | 1:00 PM | ESPN |
| Cincinnati @ (5) West Virginia | 1:00 PM | ESPN+ |
| (7) North Carolina State @ Pittsburgh | 1:00 PM | ACC Network |
| (FFO) Clemson @ (9) Stanford | 1:00 PM | |
| (9) Iowa State @ Kansas State | 1:00 PM | |
| Boston College @ (10) Syracuse | 1:00 PM | |
| (11) Miami (FL) @ Georgia Tech | 1:00 PM | |
| (3) Iowa @ Wisconsin | 2:00 PM | |
| (4) Oklahoma @ Missouri | 2:00 PM | |
| Texas A&M @ (4) Ole Miss | 2:00 PM | |
| (10) Arizona State @ (4) Texas Tech | 2:00 PM | ESPN+ |
| (6) Minnesota @ (8) Illinois | 2:00 PM | |
| (NFO) Seton Hall @ Butler | 2:30 PM | |
| (2) LSU @ (10) Mississippi State | 3:00 PM | SEC Network |
| (6) Baylor @ (3) TCU | 3:00 PM | ESPN |
| (7) Notre Dame @ (3) Louisville | 3:00 PM | ESPN2 |
| (1) UCLA @ (7) USC | 5:00 PM |
March 2
 Northern Arizona @ (12) Montana State | 0:00 | ESPN+ |
March 3
(12) San Diego State @  Air Force | 0:00 |
March 7
 Yale @ (8) Princeton | 1:00 PM | ESPN+ |