November 10
 Montana @ (10)  Kansas State | 11:00 AM | ESPN+ |
 Furman @ (NFO)  Auburn | 11:00 AM | SECN+ |
 Iona @ (3)  TCU | 4:00 PM | ESPN+ |
 New Haven @ (6)  Tennessee | 5:30 PM | SECN+ |
 San Jose State @ (2)  Oklahoma | 6:00 PM | SECN+ |
 Detroit @ (3)  Notre Dame | 6:00 PM | ACCNX |
 Lindenwood @ (4)  Louisville | 6:00 PM | ACCNX |
(12)  Villanova @ (FFO)  Princeton | 6:00 PM | ESPN+ |
(15)  McNeese @ (1)  LSU | 7:00 PM | SECN+ |
(16)  Southern @ (6)  Minnesota | 7:00 PM | B1G+ |
 North Carolina A&T @ (9)  Nebraska | 7:00 PM | B1G+ |
(10)  Arizona State @  UNLV | 8:30 PM | MW+ |
(15)  Charleston @ (4)  USC | 9:30 PM | BTN |
November 11
(8)  Colorado @ (11)  San Diego State | 0:00 | |
(FFO)  Creighton v.  South Dakota | 0:00 | |
 Bethune-Cookman @ (10)  BYU | 12:00 PM | |
 Drexel @ (4)  Virginia | 5:00 PM | |
(11)  Oregon @ (14)  Vermont | 5:00 PM | |
 Siena @ (12)  Syracuse | 5:00 PM | |
 West Florida @ (12)  Florida State | 5:00 PM | ACCNX |
 Evansville @ (3)  Kentucky | 5:30 PM | SECN+ |
 Kennesaw State @ (6)  Georgia | 5:30 PM | SECN+ |
 Oakland @ (8)  Michigan State | 5:30 PM | |
(13)  South Dakota State @ (1)  Texas | 6:00 PM | SEC Network |
 Liberty @ (7)  North Carolina State | 6:00 PM | |
 Albany @ (8)  Ole Miss | 6:00 PM | SECN+ |
 North Carolina Central @ (11)  North Carolina | 6:00 PM | ACCNX |
 UMass @ (NFO)  Harvard | 6:00 PM | ESPN+ |
 Western Kentucky @ (2)  Vanderbilt | 6:30 PM | SECN+ |
 Troy @ (7)  Mississippi State | 6:30 PM | SECN+ |
 Delaware @ (12)  Wisconsin | 6:30 PM |
November 12
 Texas Southern @ (12)  Rice | 0:00 | |
(15) Charleston @ (8)  California | 1:00 PM | ACCNX |
(4)  Oklahoma State @  Tulsa | 5:00 PM | |
(7)  Virginia Tech @  VCU | 5:00 PM | ESPN+ |
 South Florida @ (10)  Florida | 5:00 PM | SECN+ |
(2)  Connecticut @ (3)  Ohio State | 5:30 PM | FS1 |
 Middle Tennessee @ (6) Tennessee | 5:30 PM | SECN+ |
(1)  South Carolina @ (NFO)  Clemson | 6:00 PM | ESPN2 |
(2)  Michigan @ (10)  Columbia | 6:00 PM | ESPN+ |
(5)  Duke @  Norfolk State | 6:00 PM | |
(7)  Alabama @  Memphis | 6:00 PM | |
 Saint Peter's @ (10)  Miami (FL) | 6:00 PM | ACCNX |
 Merrimack @ (12) Villanova | 6:00 PM | |
(12)  Fairfield @  Seton Hall | 6:00 PM | |
 Southeastern Louisiana @ (3) TCU | 6:30 PM | |
(16)  Howard @ (11)  Iowa State | 6:30 PM | |
 Tennessee-Martin @ (FFO)  Missouri | 6:30 PM | |
 Arkansas-Pine Bluff @ (NFO)  Arkansas | 6:30 PM | SECN+ |
(4) Louisville @  Ball State | 7:00 PM | |
 Prairie View A&M @ (5)  Baylor | 7:00 PM | |
 Northern Iowa @ (6)  Iowa | 7:30 PM | BTN |
 Cal State Bakersfield @ (11)  Washington | 9:00 PM | |
 Arizona @ (1)  UCLA | 9:30 PM | BTN |
November 13
(FFO) Princeton @  Pepperdine | 0:00 | |
 Oral Roberts @ (2) Oklahoma | 10:30 AM | SECN+ |
(9)  West Virginia v.  Northwestern | 4:30 PM | |
 Denver @ (1) LSU | 6:00 PM | SECN+ |
(NFO) Auburn @ (5)  Texas Tech | 6:00 PM | |
 Samford @ (9)  Indiana | 6:00 PM | |
(11) Oregon @  Maine | 6:00 PM | |
(FFO)  Stanford @ (14)  Santa Clara | 9:00 PM |
November 14
 Tarleton State @ (1) Texas | 0:00 | |
(7) Mississippi State @  Buffalo | 11:00 AM | ESPN+ |
(3) Notre Dame v.  DePaul | 12:00 PM | |
(6) Georgia @  Ohio | 12:00 PM | ESPN+ |
| (6) Minnesota v. (10) Kansas State | 1:00 PM | |
(12) Wisconsin @ (14)  Green Bay | 1:00 PM | ESPN+ |
 Youngstown State @ (8) Colorado | 2:00 PM | |
(8) California @  UC Santa Barbara | 2:00 PM | ESPN+ |
 New Mexico @ (10) BYU | 3:00 PM | |
(11) North Carolina @  Penn | 3:00 PM | ESPN+ |
(9) Nebraska v.  Kansas | 3:30 PM |
November 15
| Southeastern Louisiana @ (5) Texas Tech | 0:00 | |
 UIC @ (11) Iowa State | 0:00 | |
 Eastern Michigan @ (3) Kentucky | 11:00 AM | SEC Network |
| (1) South Carolina v. (4) USC | 12:00 PM | ABC |
| (2) Vanderbilt v. (6) Iowa | 12:00 PM | FS1 |
(16)  Fairleigh Dickinson @ (3) Ohio State | 12:00 PM | |
(10) Columbia @ (5)  Maryland | 12:00 PM | |
| (7) North Carolina State @ Seton Hall | 12:00 PM | |
Oakland @ (11)  Miami (OH) | 12:00 PM | ESPN+ |
| (16) Southern @ (2) Oklahoma | 1:00 PM | SECN+ |
(4) Virginia @  Old Dominion | 1:00 PM | |
 La Salle @ (7) Virginia Tech | 1:00 PM | |
| (8) Michigan State @ (NFO) Harvard | 1:00 PM | ESPN+ |
 Milwaukee @ (9) Indiana | 1:00 PM | |
| (10) Florida @ (12) Florida State | 1:00 PM | ACCNX |
| (12) Villanova @ (12) Fairfield | 1:00 PM | ESPN+ |
 Abilene Christian @ (3) TCU | 2:00 PM | |
| (4) Oklahoma State @ (13) South Dakota State | 2:00 PM | |
 East Texas A&M @ (5) Baylor | 2:00 PM | |
 Marshall @ (5) Duke | 2:00 PM | ACC Network |
 Mercer @ (7) Alabama | 2:00 PM | SECN+ |
(13)  Louisiana Tech @ (8) Ole Miss | 2:00 PM | SECN+ |
 Southeast Missouri @ (9)  Illinois | 2:00 PM | |
| (FFO) Creighton @ Northern Iowa | 2:00 PM | ESPN+ |
| Lindenwood @ (FFO) Missouri | 2:00 PM | SECN+ |
 Gonzaga @ (FFO) Stanford | 4:00 PM | ACCNX |
 Stetson @ (NFO) Clemson | 4:00 PM | ACC Network |
| (2) Connecticut @ (4) Louisville | 4:30 PM | ESPN |
| (FFO) Princeton @ (1) UCLA | 5:00 PM | BTN |
 Penn State @ (10) Arizona State | 5:00 PM | |
 Canisius @ (12) Syracuse | 6:00 PM | ACC Network |
November 16
 Le Moyne @ (10) Miami (FL) | 10:00 AM | ACCNX |
| Troy @ (1) LSU | 7:00 PM | SECN+ |
(2) Michigan @  Central Michigan | 7:00 PM | ESPN+ |
(NFO) Arkansas @  Little Rock | 7:00 PM |
November 17
(11) Washington @  Washington State | 0:00 | |
 Akron @ (9) West Virginia | 9:30 AM | |
 Alabama State @ (7) Mississippi State | 11:00 AM | SECN+ |
(14)  Murray State @ (11) Oregon | 1:00 PM | |
 Tennessee State @ (4) Louisville | 5:00 PM | ACCNX |
 FGCU @ (1) South Carolina | 6:00 PM | SECN+ |
 Mount Saint Mary's @ (9) Nebraska | 6:00 PM | |
| Seton Hall @ (NFO) Auburn | 6:00 PM | SECN+ |
(6) Tennessee @  Belmont | 6:30 PM | ESPN+ |
 SMU @ (10) Kansas State | 6:30 PM | |
 Marquette @ (12) Wisconsin | 6:30 PM | |
 San Diego @ (10) Arizona State | 7:30 PM | |
| Texas Southern @ (2) Oklahoma | 8:00 PM | SEC Network |
| (12) Rice @ UNLV | 8:30 PM |
November 18
 UTA @ (3) TCU | 0:00 | |
 Saint John's @ (4) Oklahoma State | 0:00 | |
 Utah State @ (10) BYU | 3:00 PM | |
| (12) Syracuse @ (NFO) Harvard | 4:00 PM | ESPN+ |
 Coppin State @ (5) Maryland | 5:00 PM | |
(6) Georgia @  Georgia Tech | 5:00 PM | |
 South Carolina Upstate @ (NFO) Clemson | 5:00 PM | ACC Network |
| (9) Illinois @ Ball State | 5:30 PM | ESPN+ |
 Niagara @ (2) Michigan | 6:00 PM | |
| (8) Ole Miss @ (3) Ohio State | 6:00 PM | FS1 |
| (16) Southern @ (3) Notre Dame | 6:00 PM | |
 Coastal Carolina @ (9) Indiana | 6:00 PM | |
| (11) Iowa State @ Northern Iowa | 6:00 PM | ESPN+ |
 Towson @ (12) Villanova | 6:00 PM | |
 George Mason @ (FFO) Princeton | 6:00 PM | ESPN+ |
| (1) Texas @ (14) Green Bay | 6:30 PM | ESPN+ |
 North Alabama @ (2) Vanderbilt | 6:30 PM | SECN+ |
 Omaha @ (FFO) Creighton | 6:30 PM | ESPN+ |
| Kansas @ (6) Minnesota | 7:00 PM | Peacock |
| (8) Colorado @ New Mexico | 8:00 PM |
November 19
 Fordham @ (5) Duke | 10:00 AM | |
(12) Florida State v.  Purdue | 10:00 AM | ESPNU |
 James Madison @ (4) Virginia | 5:00 PM | ACC Network |
| (5) Texas Tech v. (11) North Carolina | 5:00 PM | ESPN2 |
 FAU @ (10) Florida | 5:00 PM | SECN+ |
 Sacred Heart @ (8) Michigan State | 5:30 PM | |
 Northwestern State @ (2) Oklahoma | 6:00 PM | SECN+ |
 Radford @ (6) Tennessee | 6:00 PM | SEC Network |
 Georgetown @ (7) North Carolina State | 6:00 PM | |
 FIU @ (10) Miami (FL) | 6:00 PM | ACCNX |
| (16) Fairleigh Dickinson @ (1) LSU | 7:00 PM | SECN+ |
(13)  Montana State @ (6) Iowa | 7:00 PM | |
(7) Alabama v.  Florida A&M | 7:30 PM | ESPNU |
(11) San Diego State @  Cal State Northridge | 8:00 PM | ESPN+ |
 Cal Poly @ (1) UCLA | 9:00 PM | |
| (12) Fairfield @ (11) Oregon | 9:00 PM |
November 20
| Little Rock @ (4) Oklahoma State | 0:00 | |
 UNC Asheville @ (NFO) Clemson | 4:00 PM | |
| Marshall @ (3) Kentucky | 5:00 PM | SECN+ |
(11) Miami (OH) @  Southern Indiana | 6:00 PM | |
| Middle Tennessee @ (NFO) Auburn | 6:00 PM | SECN+ |
| Seton Hall @ (2) Connecticut | 7:00 PM | Peacock |
(8) California v.  Hawaii | 7:00 PM | |
| (14) Santa Clara @ (10) Arizona State | 7:30 PM | |
(NFO) Harvard @  Colorado State | 7:30 PM | |
| (FFO) Stanford @ (11) Washington | 9:00 PM | Peacock |
| (4) USC v. (5) Baylor | 10:00 PM | BTN |
November 21
(12) Fairfield @  Oregon State | 0:00 | |
 Morgan State @ (5) Maryland | 11:00 AM | |
(12) Florida State v.  UCF | 11:00 AM | ESPN+ |
(1) South Carolina @  Providence | 12:30 PM | |
| (5) Texas Tech v. Purdue | 1:30 PM | |
 Northern Colorado @ (10) BYU | 3:00 PM | |
| (7) Alabama v. (11) North Carolina | 4:00 PM | ESPN+ |
| (5) Duke @ (10) Columbia | 6:00 PM | ESPN+ |
November 22
 Drake @ (11) Iowa State | 0:00 | |
| Pepperdine @ (12) Rice | 0:00 | |
(NFO) Harvard @  Wyoming | 0:00 | |
| (1) Texas v. (3) Ohio State | 12:00 PM | ESPN |
| (5) Texas Tech v. South Florida | 12:00 PM | |
| (13) Louisiana Tech @ (6) Georgia | 12:00 PM | SECN+ |
 Lafayette @ (12) Wisconsin | 12:00 PM | |
| Georgia Tech @ (FFO) Princeton | 12:00 PM | ESPN+ |
| (9) Nebraska @ (FFO) Creighton | 1:00 PM | |
| Southern Indiana @ (9) Indiana | 1:00 PM | |
 Northern Kentucky @ (5) Baylor | 2:00 PM | |
| Central Michigan @ (6) Minnesota | 2:00 PM | |
(7) Mississippi State @  Southern Miss | 2:00 PM | |
| Coastal Carolina @ (7) North Carolina State | 2:00 PM | ACC Network |
 Alabama A&M @ (8) Ole Miss | 2:00 PM | |
| Utah State @ (3) TCU | 2:30 PM | |
 Winthrop @ (11) San Diego State | 3:00 PM | |
(4) Oklahoma State v.  Wichita State | 4:00 PM | |
| Cal Poly @ (11) Washington | 4:00 PM | |
(FFO) Stanford @  Portland | 4:00 PM | |
| (1) UCLA @ (6) Tennessee | 4:30 PM | ESPN |
| (10) Kansas State v. (FFO) Missouri | 6:30 PM |
November 23
(8) Michigan State v.  Alcorn State | 11:00 AM | |
(6) Iowa v.  Utah | 12:30 PM | |
| (2) Oklahoma v. (4) Virginia | 1:30 PM | |
| (7) Virginia Tech v. Tennessee-Martin | 1:30 PM | |
| (2) Michigan v. (10) Miami (FL) | 3:00 PM | |
| (2) Vanderbilt v. Arizona | 4:00 PM | |
| (8) California v. Gonzaga | 5:00 PM | |
| Belmont @ (1) LSU | 7:00 PM | SECN+ |
 Northern Arizona @ (4) USC | 9:00 PM |
November 24
| La Salle @ (12) Villanova | 10:30 AM | |
(3) Notre Dame v.  Davidson | 12:00 PM | ESPN+ |
| (9) West Virginia v. (10) Florida | 2:30 PM | ESPN+ |
| (2) Oklahoma v. (13) Montana State | 3:00 PM | |
| (1) UCLA v. Saint John's | 4:00 PM | |
 SIUE @ (FFO) Missouri | 5:30 PM | SECN+ |
(NFO) Arkansas v. (16)  High Point | 5:30 PM | |
 Monmouth @ (5) Maryland | 6:00 PM | |
 ULM @ (7) Alabama | 6:00 PM | SECN+ |
 Gardner-Webb @ (11) North Carolina | 6:00 PM | ACCNX |
| (1) South Carolina v. (2) Connecticut | 7:00 PM | |
 UMKC @ (9) Nebraska | 7:00 PM | |
(10) BYU @  Utah Valley | 7:00 PM | ESPN+ |
| San Jose State @ (10) Arizona State | 7:30 PM | |
(4) Virginia v.  UAB | 8:00 PM |
November 25
 Illinois State @ (NFO) Harvard | 0:00 | ESPN+ |
(6) Iowa v.  Navy | 10:00 AM | |
| (12) Syracuse v. (16) Southern | 10:00 AM | |
 Rutgers @ (FFO) Princeton | 11:00 AM | ESPN+ |
 UTRGV @ (12) Rice | 12:00 PM | |
(2) Michigan v.  Toledo | 12:30 PM | |
| (12) Wisconsin v. (NFO) Auburn | 12:30 PM | |
| (10) Miami (FL) v. Utah | 3:00 PM | |
| (2) Vanderbilt v. Oregon State | 5:30 PM | |
| (NFO) Arkansas v. James Madison | 5:30 PM | |
| Southeastern Louisiana @ (1) Texas | 6:00 PM | SEC Network |
| Samford @ (7) Alabama | 6:00 PM | SECN+ |
November 26
(11) Oregon v.  Maryland Eastern Shore | 10:00 AM | |
(NFO) Clemson v.  Robert Morris | 10:00 AM | |
| (NFO) Auburn v. (16) Southern | 10:00 AM | |
| (3) Notre Dame v. (9) West Virginia | 10:30 AM | ESPN2 |
| (6) Georgia v. (8) Colorado | 12:30 PM | |
| (12) Wisconsin v. (12) Syracuse | 12:30 PM | |
| (10) Florida v. Davidson | 1:00 PM | ESPNU |
(12) Fairfield v.  North Dakota State | 2:30 PM | |
(5) Texas Tech v.  Air Force | 4:30 PM | |
(6) Minnesota v. (15)  Missouri State | 5:30 PM | |
(11) Miami (OH) v.  Cincinnati | 8:00 PM |
November 27
| (7) Mississippi State v. (9) Indiana | 10:00 AM | |
| (8) Colorado v. (11) Oregon | 10:00 AM | |
| (9) Illinois v. Marquette | 10:00 AM | |
| (12) Syracuse v. (NFO) Auburn | 10:00 AM | |
(FFO) Missouri v.  Tulane | 11:15 AM | |
| Akron @ (4) Louisville | 12:00 PM | ACCNX |
| (3) TCU v. Georgia Tech | 12:30 PM | |
| (4) Oklahoma State v. (11) Washington | 12:30 PM | |
(4) USC v.  Saint Joseph's | 12:30 PM | |
| (6) Georgia v. Maryland Eastern Shore | 12:30 PM | |
| (10) BYU v. (12) Fairfield | 1:30 PM | |
| (NFO) Clemson v. Georgetown | 1:30 PM | |
| Delaware @ (8) California | 2:00 PM | ACCNX |
| (11) Iowa State v. Belmont | 3:00 PM | |
 Lamar @ (12) Rice | 3:00 PM | |
(FFO) Creighton v.  Houston | 3:00 PM | |
| (1) LSU v. (12) Villanova | 3:30 PM | |
| (3) Kentucky v. Maine | 3:45 PM | |
| (11) San Diego State @ Hawaii | 4:00 PM | |
(12) Florida State v.  Dayton | 4:00 PM | ESPN+ |
| (5) Baylor v. Penn State | 4:30 PM | |
| (6) Tennessee @ FGCU | 5:30 PM | |
| (11) Miami (OH) v. Kansas | 5:30 PM | |
| (7) North Carolina State v. (10) Kansas State | 6:00 PM | |
(16)  Army @ (11) North Carolina | 6:00 PM | ACCNX |
| (10) Columbia v. (FFO) Stanford | 6:30 PM | |
| (6) Minnesota v. Cincinnati | 8:00 PM |
November 28
 East Carolina @ (8) California | 0:00 | |
(NFO) Harvard v.  Pittsburgh | 0:00 | |
| (3) TCU v. (7) Mississippi State | 10:00 AM | |
| (8) Colorado v. Maryland Eastern Shore | 10:00 AM | |
| (3) Ohio State v. VCU | 11:00 AM | |
(FFO) Missouri v.  Boise State | 12:15 PM | |
| (4) Oklahoma State v. UMass | 12:30 PM | |
| (6) Georgia v. (11) Oregon | 12:30 PM | |
| (9) Indiana v. Georgia Tech | 12:30 PM | |
| Tennessee State @ (1) South Carolina | 1:30 PM | SECN+ |
(10) BYU v.  Boston College | 1:30 PM | |
| (3) Kentucky v. (13) South Dakota State | 2:30 PM | |
| (5) Maryland @ Towson | 3:00 PM | |
| (1) LSU v. (7) North Carolina State | 3:30 PM | |
| Cal State Bakersfield @ (10) Arizona State | 3:30 PM | |
| (10) Columbia @ Hawaii | 4:00 PM | |
| (2) Connecticut v. (5) Duke | 6:00 PM | |
| (10) Kansas State v. (12) Villanova | 6:00 PM | |
| (11) San Diego State v. (FFO) Stanford | 6:30 PM |
November 29
| (9) Illinois v. Saint Joseph's | 10:00 AM | |
 East Tennessee State @ (4) Louisville | 11:00 AM | ACC Network |
| (12) Florida State v. VCU | 11:00 AM | ESPN+ |
 Georgia State @ (2) Vanderbilt | 12:00 PM | SEC Network |
| (4) USC v. (11) Iowa State | 12:30 PM | |
| (11) Washington v. UMass | 12:30 PM | |
 UNCG @ (7) Virginia Tech | 1:00 PM | |
| Eastern Michigan @ (8) Michigan State | 1:00 PM | |
| Arkansas-Pine Bluff @ (10) Miami (FL) | 1:00 PM | ACCNX |
 Elon @ (NFO) Clemson | 1:00 PM | ACC Network |
 Wake Forest @ (10) Arizona State | 1:30 PM | |
| (1) Texas @ Southeast Missouri | 2:00 PM | |
| Memphis @ (8) Ole Miss | 2:00 PM | SEC Network |
| (13) Louisiana Tech @ (NFO) Arkansas | 2:00 PM | SECN+ |
 Brown @ (11) North Carolina | 3:00 PM | ACC Network |
| (FFO) Stanford @ Hawaii | 3:00 PM | |
| Penn @ (1) UCLA | 4:00 PM | |
| (4) Virginia @ SMU | 5:00 PM | ACC Network |
| (10) Columbia v. (11) San Diego State | 5:30 PM |
November 30
| Southern Indiana @ (2) Michigan | 6:00 PM | |
| Coppin State @ (9) West Virginia | 6:00 PM |
December 1
| Texas Southern @ (5) Texas Tech | 0:00 | |
| Norfolk State @ (11) Iowa State | 0:00 | |
(12) Villanova @  Temple | 0:00 | |
| Ball State @ (5) Maryland | 5:30 PM | |
| (6) Iowa @ Drake | 6:00 PM | |
| Oral Roberts @ (4) Oklahoma State | 6:30 PM | |
(15)  Central Arkansas @ (10) Kansas State | 6:30 PM | |
| Omaha @ (9) Nebraska | 7:00 PM |
December 2
 Grambling State @ (12) Rice | 0:00 | |
| (10) Miami (FL) @ (10) Florida | 4:00 PM | ESPNU |
| UNLV @ (2) Connecticut | 5:30 PM | |
| Akron @ (3) Ohio State | 5:30 PM | |
| Boston College @ (9) Indiana | 6:00 PM | |
| (FFO) Princeton @ Seton Hall | 6:00 PM | |
| (1) LSU @ (11) North Carolina | 6:15 PM | ESPN2 |
| (7) North Carolina State @ (8) Ole Miss | 6:15 PM | ESPNU |
| (FFO) Stanford @ (NFO) Auburn | 6:15 PM | SEC Network |
(5) Baylor @  North Texas | 6:30 PM | |
 Western Michigan @ (12) Wisconsin | 6:30 PM | |
 Saint Thomas @ (6) Minnesota | 7:00 PM | |
| (16) Southern @ (11) Oregon | 8:00 PM | |
| (4) Louisville @ (1) Texas | 8:15 PM | ESPN2 |
| (6) Georgia @ SMU | 8:15 PM | ACC Network |
December 3
(12) Fairfield @  Lehigh | 10:00 AM | |
| Maine @ (8) Michigan State | 5:30 PM | |
| (1) South Carolina @ (5) Duke | 6:00 PM | ESPN |
| (2) Oklahoma @ (12) Syracuse | 6:00 PM | ESPNU |
| (NFO) Clemson @ (3) Kentucky | 6:00 PM | ESPN2 |
| (3) TCU @ Memphis | 6:00 PM | |
| Georgia Tech @ (7) Alabama | 6:00 PM | SEC Network |
| Mount Saint Mary's @ (9) West Virginia | 6:00 PM | |
| Old Dominion @ (10) Columbia | 6:00 PM | |
| DePaul @ (12) Villanova | 6:00 PM | |
| (FFO) Missouri @ (12) Florida State | 6:00 PM | ACC Network |
| Northern Iowa @ (10) Kansas State | 6:30 PM | |
| (8) Colorado @ Denver | 7:00 PM | |
| (3) Notre Dame @ (2) Vanderbilt | 8:00 PM | ESPN |
| (4) Virginia @ (7) Mississippi State | 8:00 PM | ESPNU |
| (6) Tennessee @ (7) Virginia Tech | 8:00 PM | ESPN2 |
 Texas A&M @ (8) California | 8:00 PM | ACC Network |
| Wake Forest @ (NFO) Arkansas | 8:00 PM | SEC Network |
| (11) San Diego State @ (14) Santa Clara | 9:00 PM |
December 4
| (NFO) Harvard @ (9) West Virginia | 6:00 PM | |
| (2) Michigan v. (2) Oklahoma | 10:59 PM | Fox |
December 5
| (FFO) Princeton @ (12) Rice | 0:00 | |
| Drake @ (FFO) Creighton | 0:00 | |
| (3) Ohio State @ Rutgers | 11:00 AM | BTN |
| (9) Indiana @ Northwestern | 1:00 PM | BTN |
| (9) Illinois @ (12) Wisconsin | 2:00 PM | |
| (2) Connecticut v. (5) Maryland | 3:30 PM | Fox |
| (10) BYU @ Oregon State | 3:30 PM | CW |
| (4) USC @ (11) Washington | 5:00 PM | Peacock |
| (9) Nebraska @ (6) Iowa | 5:00 PM | BTN |
December 6
December 7
 Chicago State @ (9) Illinois | 11:00 AM | |
 Kent State @ (2) Michigan | 6:00 PM | |
| Lehigh @ (5) Maryland | 6:00 PM | |
(FFO) Princeton @  Houston Christian | 6:00 PM | |
(8) California @  Loyola-Marymount | 9:30 PM |
December 8
(16)  Western Illinois @ (10) Kansas State | 5:30 PM | |
| North Carolina Central @ (6) Tennessee | 6:00 PM | SEC Network |
| UTRGV @ (10) Arizona State | 6:00 PM | |
 North Dakota @ (9) Nebraska | 7:00 PM | |
| Grambling State @ (4) USC | 9:00 PM |
December 9
| (10) Columbia @ Saint Joseph's | 10:00 AM | |
| Winthrop @ (11) North Carolina | 10:00 AM | |
| Texas Southern @ (5) Baylor | 11:00 AM | |
(11) San Diego State @  Saint Mary's College | 2:00 PM | |
 Southern Utah @ (10) BYU | 3:00 PM | |
| (2) Vanderbilt @ Davidson | 4:00 PM | |
 American @ (4) Virginia | 5:00 PM | |
 Appalachian State @ (7) Virginia Tech | 5:00 PM | |
| (12) Fairfield v. Maine | 5:00 PM | |
| Milwaukee @ (8) Michigan State | 5:30 PM | |
| (2) Connecticut @ (3) Notre Dame | 6:00 PM | ESPN |
| SIUE @ (2) Oklahoma | 6:00 PM | SEC Network |
(16)  Jacksonville @ (7) North Carolina State | 6:00 PM | |
| Northern Kentucky @ (9) Indiana | 6:00 PM | |
| Northern Iowa @ (6) Minnesota | 7:00 PM | |
| (11) Iowa State @ (6) Iowa | 7:00 PM | FS1 |
| (4) Louisville @ (3) Kentucky | 8:00 PM | ESPN |
December 10
(13)  Rhode Island @ (FFO) Princeton | 10:00 AM | |
(12) Wisconsin @  Valparaiso | 6:00 PM | |
 UTSA @ (3) TCU | 6:30 PM | |
 Arkansas State @ (1) Texas | 7:00 PM | |
| (FFO) Missouri @ (9) Illinois | 7:00 PM | BTN |
| (12) Villanova @ Marquette | 8:00 PM | truTV |
| (16) Southern @ (11) Washington | 9:00 PM |
December 11
(11) San Diego State @  Pacific | 0:00 | |
| Houston @ (12) Rice | 11:15 AM | |
| (2) Michigan @ (5) Maryland | 6:00 PM | Peacock |
| Cal State Bakersfield @ (1) UCLA | 9:00 PM |
December 12
 San Francisco @ (8) Colorado | 0:00 | |
 Wofford @ (1) South Carolina | 11:00 AM | |
| (2) Oklahoma v. (4) Oklahoma State | 11:00 AM | ESPN2 |
| Texas A&M @ (9) Nebraska | 11:00 AM | BTN |
 South Carolina State @ (8) Ole Miss | 12:00 PM | |
| (6) Tennessee @ (2) Connecticut | 1:30 PM | |
| UMKC @ (6) Minnesota | 2:00 PM | |
| Northern Colorado @ (11) Washington | 4:00 PM | |
| (9) West Virginia @ (12) Villanova | 5:00 PM | |
| (10) Kansas State v. (FFO) Creighton | 5:00 PM | |
| (10) Arizona State v. Washington State | 5:30 PM | |
(15)  California Baptist @ (10) BYU | 5:30 PM |
December 13
December 14
| South Carolina State @ (6) Georgia | 10:00 AM | |
 West Georgia @ (7) Alabama | 11:00 AM | |
| Bethune-Cookman @ (10) Florida | 5:00 PM | |
| North Texas @ (4) Oklahoma State | 6:30 PM |
December 15
 Utah Tech @ (8) Colorado | 0:00 | |
 Western Carolina @ (NFO) Clemson | 10:00 AM | |
 Stonehill @ (1) LSU | 11:00 AM | |
 Weber State @ (10) BYU | 3:00 PM | |
| Alabama A&M @ (6) Tennessee | 6:00 PM | SEC Network |
| (8) Ole Miss @ Norfolk State | 6:00 PM | |
| Robert Morris @ (9) West Virginia | 6:00 PM | |
| (15) Central Arkansas @ (NFO) Arkansas | 6:30 PM | |
 Mercyhurst @ (6) Minnesota | 7:00 PM |
December 16
 North Florida @ (5) Texas Tech | 0:00 | |
| Little Rock @ (1) Texas | 11:00 AM | |
| Portland @ (11) Oregon | 5:00 PM | |
| (12) Syracuse @ Le Moyne | 5:00 PM | |
| (11) Miami (OH) @ (3) Ohio State | 5:30 PM | |
| Albany @ (1) South Carolina | 6:00 PM | |
| (1) UCLA v. (5) Duke | 6:00 PM | |
| (FFO) Creighton @ (2) Connecticut | 6:00 PM | Peacock |
| Alcorn State @ (7) Alabama | 6:00 PM | |
| (10) Columbia @ (12) Fairfield | 6:00 PM | |
| Samford @ (7) Mississippi State | 6:30 PM | |
| (4) USC v. (10) Miami (FL) | 8:30 PM |
December 17
 Delaware State @ (12) Wisconsin | 11:00 AM | |
| (16) Jacksonville @ (6) Georgia | 3:00 PM | |
 Jackson State @ (NFO) Auburn | 4:00 PM | |
| (7) North Carolina State @ (12) Florida State | 5:00 PM | |
| Norfolk State @ (10) Florida | 5:00 PM | |
| Georgia Tech @ (11) North Carolina | 5:00 PM | ACC Network |
| Northern Kentucky @ (4) Louisville | 6:00 PM | |
| (12) Rice @ Middle Tennessee | 6:00 PM | |
 Jacksonville State @ (FFO) Missouri | 6:30 PM | |
| (10) Arizona State @ (FFO) Stanford | 9:00 PM | |
| (14) Santa Clara @ (11) Washington | 9:00 PM |
December 18
 Bucknell @ (12) Syracuse | 9:00 AM | |
 UMBC @ (5) Maryland | 10:00 AM | |
| (5) Baylor v. (6) Tennessee | 5:00 PM | ESPN2 |
| (16) Western Illinois @ (9) Illinois | 6:00 PM | |
| (2) Vanderbilt v. Belmont | 7:30 PM | ESPNU |
December 19
| (11) Iowa State @ (10) Kansas State | 0:00 | |
| Wake Forest @ (7) Virginia Tech | 1:00 PM | |
| (8) Michigan State v. Gonzaga | 1:00 PM | |
| (11) Miami (OH) @ (14) Green Bay | 1:00 PM | |
| (15) Missouri State @ (NFO) Arkansas | 2:00 PM | |
| (10) BYU @ Arizona | 3:00 PM | |
| (13) Montana State @ (11) Oregon | 4:00 PM | |
| (1) Texas v. (5) Duke | 5:00 PM | ESPN2 |
(12) Fairfield @  Manhattan | 5:00 PM | |
| (1) South Carolina v. (1) UCLA | 7:30 PM | ESPN |
| (3) Notre Dame v. (4) USC | 10:00 PM | ESPN |
December 20
| Cincinnati @ (3) TCU | 0:00 | |
| (4) Oklahoma State @ Kansas | 0:00 | |
| (8) Colorado @ (5) Texas Tech | 0:00 | |
| Grambling State @ (6) Minnesota | 10:00 AM | |
| Navy @ (7) North Carolina State | 11:00 AM | ACC Network |
 Charleston Southern @ (10) Florida | 11:00 AM | SEC Network |
| Omaha @ (12) Wisconsin | 11:00 AM | |
 UC Davis @ (NFO) Harvard | 11:00 AM | |
| (1) LSU v. (2) Connecticut | 12:00 PM | ABC |
| (7) Mississippi State @ Davidson | 12:00 PM | |
(16)  Chattanooga @ (7) Alabama | 12:00 PM | |
| (12) Florida State @ (9) Indiana | 12:00 PM | |
| (12) Villanova @ Providence | 12:00 PM | |
| (8) Ole Miss v. Temple | 12:15 PM | |
| (9) West Virginia @ UCF | 1:00 PM | |
| Morgan State @ (10) Miami (FL) | 1:00 PM | ACC Network |
 Wright State @ (9) Illinois | 2:00 PM | |
| Prairie View A&M @ (12) Rice | 2:00 PM | |
| (FFO) Creighton @ DePaul | 2:00 PM | |
| (3) Kentucky v. (4) Virginia | 2:30 PM | ESPN2 |
(11) San Diego State v.  IU Indianapolis | 2:30 PM | |
| (1) UCLA v. (1) Texas | 4:00 PM | ESPN |
 Portland State @ (11) Washington | 4:00 PM | |
| (NFO) Clemson @ (4) Louisville | 4:30 PM | ESPN2 |
| (8) California v. (9) Nebraska | 5:00 PM | BTN |
 Austin Peay @ (FFO) Missouri | 5:00 PM | SEC Network |
| (1) South Carolina v. (3) Notre Dame | 6:30 PM | ESPN |
| (3) Ohio State v. (FFO) Stanford | 7:30 PM | BTN |
 Northern Illinois @ (6) Iowa | 7:30 PM | |
| (NFO) Auburn v. South Florida | 8:00 PM | |
| (4) USC v. (5) Duke | 9:00 PM | ESPN |
December 21
| (5) Baylor @ Houston | 0:00 | |
| Utah @ (10) Arizona State | 0:00 | |
| Detroit @ (2) Michigan | 11:00 AM | |
| Radford @ (7) Virginia Tech | 11:00 AM | |
| Tennessee State @ (2) Vanderbilt | 12:00 PM | |
| (8) Ole Miss v. (13) South Dakota State | 12:15 PM | |
| ULM @ (2) Oklahoma | 1:00 PM | |
 Morehead State @ (6) Tennessee | 1:00 PM | |
| Alabama State @ (6) Georgia | 1:00 PM | |
| Coastal Carolina @ (7) Alabama | 2:00 PM | |
(11) San Diego State v.  Saint Louis | 2:30 PM | |
| Norfolk State @ (11) North Carolina | 3:00 PM | ACC Network |
| (NFO) Auburn v. Tulsa | 3:00 PM | |
| Merrimack @ (12) Fairfield | 6:00 PM |
December 22
| Old Dominion @ (9) Illinois | 11:00 AM | |
| Boston College @ (10) Miami (FL) | 11:00 AM | |
 Stony Brook @ (4) Virginia | 12:00 PM | |
| Florida A&M @ (10) Florida | 12:00 PM | |
| Southern Utah @ (8) California | 2:00 PM | |
 Butler @ (FFO) Creighton | 5:00 PM |
December 23
| (2) Connecticut @ (12) Villanova | 12:00 PM | Peacock |
December 27
| Alcorn State @ (1) LSU | 2:00 PM | |
 Mississippi Valley State @ (8) Ole Miss | 2:00 PM |
December 28
| (15) Charleston @ (7) Virginia Tech | 1:00 PM | |
| Kent State @ (3) Kentucky | 2:00 PM | |
 Georgia Southern @ (6) Georgia | 2:00 PM | |
| Jackson State @ (7) Mississippi State | 3:00 PM | |
| Cal Poly @ (FFO) Stanford | 4:00 PM | |
| Gardner-Webb @ (1) South Carolina | 5:00 PM | |
| Norfolk State @ (4) Virginia | 5:00 PM | |
| (12) Syracuse @ (5) Duke | 5:00 PM | ACC Network |
| (3) Notre Dame @ Pittsburgh | 6:00 PM | |
| Bethune-Cookman @ (10) Miami (FL) | 6:00 PM | |
| Kennesaw State @ (NFO) Clemson | 6:00 PM | |
 South Alabama @ (NFO) Auburn | 6:00 PM | |
| Little Rock @ (2) Vanderbilt | 6:30 PM | |
| ULM @ (NFO) Arkansas | 6:30 PM | |
| (NFO) Harvard @ (1) Texas | 7:00 PM | |
 UNCW @ (11) North Carolina | 7:00 PM | ACC Network |
December 29
| (6) Iowa @ (9) Illinois | 12:00 PM | Peacock |
| (4) USC @ (12) Wisconsin | 2:00 PM | Peacock |
| (8) Michigan State @ (2) Michigan | 5:00 PM | FS1 |
| (12) Fairfield @ Siena | 5:00 PM | |
| (11) Oregon @ (3) Ohio State | 5:30 PM | |
| Rutgers @ (9) Indiana | 6:00 PM | |
| Oregon State @ (10) Columbia | 6:00 PM | |
| (11) Washington @ (9) Nebraska | 7:00 PM |
December 30
| (3) TCU @ (11) Iowa State | 0:00 | |
| Arizona @ (4) Oklahoma State | 0:00 | |
| (5) Texas Tech @ (5) Baylor | 0:00 | |
| (10) Arizona State @ (8) Colorado | 0:00 | |
| Kansas @ (9) West Virginia | 0:00 | |
| (FFO) Creighton @ Seton Hall | 12:00 PM | |
| (6) Minnesota @ (5) Maryland | 3:00 PM | |
| (12) Rice @ East Carolina | 5:00 PM | |
| Georgetown @ (12) Villanova | 6:00 PM | |
| Northwestern @ (1) UCLA | 8:00 PM | |
| (10) Kansas State @ (10) BYU | 8:00 PM |
December 31
| (4) Louisville @ Boston College | 11:00 AM | |
| (1) Texas @ (6) Georgia | 1:00 PM | |
| (10) Miami (FL) @ (7) North Carolina State | 1:00 PM | |
| (7) Virginia Tech @ Pittsburgh | 1:00 PM | |
| (12) Florida State @ Georgia Tech | 1:00 PM | |
| (3) Kentucky @ (10) Florida | 2:00 PM | |
| (6) Tennessee @ Texas A&M | 2:00 PM | |
| (7) Mississippi State @ (FFO) Missouri | 3:00 PM | |
(2) Connecticut @  Xavier | 4:00 PM | FS1 |
| (8) California @ (3) Notre Dame | 4:00 PM | |
| (11) North Carolina @ (12) Syracuse | 5:00 PM | ACC Network |
| (7) Alabama @ (1) South Carolina | 6:00 PM | SEC Network |
| (1) LSU @ (NFO) Auburn | 6:00 PM | |
| (FFO) Stanford @ (NFO) Clemson | 6:00 PM | |
| (2) Oklahoma @ (8) Ole Miss | 7:00 PM | |
| (5) Duke @ (4) Virginia | 7:00 PM | ACC Network |
| (NFO) Arkansas @ (2) Vanderbilt | 8:00 PM | SEC Network |
January 1
| (2) Michigan @ Purdue | 11:00 AM | BTN |
| Oregon State @ (FFO) Princeton | 12:00 PM | |
| (6) Iowa @ (8) Michigan State | 1:00 PM | BTN |
 Rider @ (12) Fairfield | 1:00 PM | |
| (11) Oregon @ Penn State | 3:00 PM | BTN |
January 2
| (10) Arizona State @ UCF | 12:00 PM | |
| (9) Illinois @ Rutgers | 1:00 PM | |
| (12) Villanova @ Saint John's | 1:00 PM | |
| (11) Miami (OH) @ Buffalo | 1:00 PM | |
| (FFO) Creighton @ Georgetown | 1:00 PM | |
 Dartmouth @ (NFO) Harvard | 1:00 PM | |
| (5) Maryland @ (3) Ohio State | 3:00 PM | BTN |
| Houston @ (10) BYU | 3:00 PM | |
| Northwestern @ (4) USC | 4:00 PM | |
| (12) Wisconsin @ (11) Washington | 4:00 PM | |
| (12) Rice @ Temple | 4:00 PM | |
| (5) Baylor @ (8) Colorado | 5:00 PM | CBSSN |
| (9) Indiana @ (6) Minnesota | 5:00 PM | BTN |
| (5) Texas Tech @ (3) TCU | 6:00 PM | |
| (10) Kansas State @ Utah | 6:00 PM | |
| (9) Nebraska @ (1) UCLA | 7:00 PM | BTN |
January 3
| (NFO) Auburn @ (3) Kentucky | 11:00 AM | SEC Network |
| Georgia Tech @ (4) Virginia | 11:00 AM | ACC Network |
| (2) Vanderbilt @ (1) LSU | 12:00 PM | ABC |
(10) Columbia @  Cornell | 12:00 PM | |
| (8) California @ (4) Louisville | 1:00 PM | ACC Network |
| (10) Florida @ (NFO) Arkansas | 1:00 PM | SEC Network |
| (11) North Carolina @ (NFO) Clemson | 1:00 PM | CW |
| (12) Florida State @ Boston College | 1:00 PM | |
| Iona @ (12) Fairfield | 1:00 PM | |
| (1) South Carolina @ (1) Texas | 2:00 PM | ABC |
| (5) Duke @ (7) North Carolina State | 2:00 PM | ESPN |
| Texas A&M @ (7) Mississippi State | 2:00 PM | |
| (FFO) Stanford @ SMU | 2:00 PM | |
| (2) Connecticut @ DePaul | 3:00 PM | NBC |
| (FFO) Missouri @ (2) Oklahoma | 3:00 PM | SEC Network |
| (12) Syracuse @ (7) Virginia Tech | 3:00 PM | ACC Network |
| (11) Iowa State @ Arizona | 3:00 PM | |
| (8) Ole Miss @ (6) Tennessee | 4:00 PM | ESPN |
| (3) Notre Dame @ (10) Miami (FL) | 5:00 PM | ACC Network |
| (6) Georgia @ (7) Alabama | 5:00 PM | SEC Network |
| (9) West Virginia @ (4) Oklahoma State | 7:00 PM |
January 5
| Penn @ (FFO) Princeton | 5:00 PM | |
| (1) UCLA @ Purdue | 6:00 PM | |
| Cincinnati @ (5) Texas Tech | 6:00 PM | |
| (5) Maryland @ (9) Indiana | 6:00 PM | |
| Penn State @ (6) Minnesota | 7:00 PM | |
| Rutgers @ (6) Iowa | 7:00 PM | |
| (9) Nebraska @ (4) USC | 9:00 PM | BTN |
| (12) Wisconsin @ (11) Oregon | 9:00 PM |
January 6
| Utah State @ (11) San Diego State | 0:00 | |
| Toledo @ (11) Miami (OH) | 6:00 PM | |
| Utah @ (3) TCU | 6:30 PM | |
| (8) Colorado @ (4) Oklahoma State | 6:30 PM | |
| UCF @ (10) Kansas State | 6:30 PM | |
| (10) BYU @ (5) Baylor | 7:00 PM | |
| (9) West Virginia @ Houston | 7:00 PM | |
| FAU @ (12) Rice | 7:00 PM | |
| (11) Iowa State @ (10) Arizona State | 7:30 PM |
January 7
| (3) Notre Dame @ (7) Virginia Tech | 5:00 PM | |
| (4) Louisville @ (12) Florida State | 5:00 PM | ACC Network |
| Pittsburgh @ (12) Syracuse | 5:00 PM | |
| (1) South Carolina @ (7) Mississippi State | 6:00 PM | SEC Network |
| (6) Tennessee @ (1) Texas | 6:00 PM | |
| (3) Ohio State @ (2) Michigan | 6:00 PM | Peacock |
| Georgetown @ (2) Connecticut | 6:00 PM | TNT |
| (6) Georgia @ (2) Oklahoma | 6:00 PM | |
| (2) Vanderbilt @ (NFO) Auburn | 6:00 PM | |
| (10) Florida @ (7) Alabama | 6:00 PM | |
| (NFO) Clemson @ Georgia Tech | 6:00 PM | |
| (3) Kentucky @ (FFO) Missouri | 6:30 PM | |
| (8) Ole Miss @ (NFO) Arkansas | 6:30 PM | |
| (8) Michigan State @ Northwestern | 7:00 PM | BTN |
| Wake Forest @ (11) North Carolina | 7:00 PM | ACC Network |
| (12) Villanova @ (FFO) Creighton | 7:00 PM | Peacock |
| Texas A&M @ (1) LSU | 8:00 PM | SEC Network |
| (7) North Carolina State @ (8) California | 8:00 PM | |
| (11) Washington @ (9) Illinois | 8:00 PM | Peacock |
| (10) Miami (FL) @ (FFO) Stanford | 9:00 PM |
January 8
| (1) UCLA @ (9) Indiana | 5:00 PM | Peacock |
| (4) USC @ (5) Maryland | 7:00 PM | Peacock |
January 9
| (NFO) Harvard @ (10) Columbia | 0:00 | |
| (11) Miami (OH) @ Ball State | 10:00 AM | |
| (6) Iowa @ (6) Minnesota | 11:00 AM | Fox |
 Yale @ (FFO) Princeton | 1:00 PM | |
| (12) Fairfield @ Merrimack | 1:00 PM | |
| Utah @ (5) Texas Tech | 2:00 PM | |
| North Texas @ (12) Rice | 2:00 PM | |
| Arizona @ (10) Kansas State | 5:00 PM | |
| (10) Arizona State @ (10) BYU | 5:00 PM | |
| (4) Oklahoma State @ (11) Iowa State | 7:00 PM | FS1 |
| UCF @ (8) Colorado | 7:00 PM | |
| (5) Baylor @ Kansas | 7:30 PM | CBSSN |
January 10
| (11) Oregon @ (2) Michigan | 11:00 AM | Peacock |
| (5) Duke @ (3) Notre Dame | 11:00 AM | ABC |
| (NFO) Auburn @ (6) Georgia | 11:00 AM | SEC Network |
| (12) Syracuse @ (12) Florida State | 11:00 AM | ACC Network |
| (1) Texas @ (3) Kentucky | 1:00 PM | ABC |
| (1) LSU @ (10) Florida | 1:00 PM | SEC Network |
| (2) Connecticut @ (FFO) Creighton | 1:00 PM | Peacock |
| (7) Virginia Tech @ (4) Virginia | 1:00 PM | CW |
| (7) North Carolina State @ (FFO) Stanford | 1:00 PM | ACC Network |
| (11) Washington @ Northwestern | 1:00 PM | |
| Xavier @ (12) Villanova | 1:00 PM | |
| Purdue @ (9) Illinois | 1:30 PM | BTN |
| (3) Ohio State @ (12) Wisconsin | 2:00 PM | |
| (3) TCU @ (9) West Virginia | 2:00 PM | |
| (11) North Carolina @ (4) Louisville | 2:00 PM | |
| (FFO) Missouri @ Texas A&M | 2:00 PM | |
| (NFO) Arkansas @ (1) South Carolina | 3:00 PM | SEC Network |
| Boise State @ (11) San Diego State | 3:00 PM | CW |
| (8) Michigan State @ (9) Nebraska | 3:30 PM | BTN |
| (2) Oklahoma @ (6) Tennessee | 4:00 PM | ESPN |
| (10) Miami (FL) @ (8) California | 4:00 PM | ACC Network |
| (7) Mississippi State @ (2) Vanderbilt | 5:00 PM | SEC Network |
January 11
| (4) USC @ Rutgers | 6:00 PM | BTN |
| (7) Alabama @ (8) Ole Miss | 6:00 PM | SEC Network |
January 12
| (9) Indiana @ Penn State | 5:00 PM | |
| (6) Minnesota @ (1) UCLA | 9:30 PM | BTN |
January 13
| Siena @ (12) Fairfield | 10:00 AM | |
| (10) Kansas State @ (9) West Virginia | 4:00 PM | CBSSN |
| (9) Illinois @ (3) Ohio State | 5:30 PM | |
| (11) Oregon @ (8) Michigan State | 5:30 PM | |
| (2) Michigan @ (9) Nebraska | 6:00 PM | FS1 |
| Marquette @ (2) Connecticut | 6:00 PM | truTV |
| Butler @ (12) Villanova | 6:00 PM | |
| UMass @ (11) Miami (OH) | 6:00 PM | |
| Kansas @ (4) Oklahoma State | 6:30 PM | |
| (5) Texas Tech @ Arizona | 7:00 PM | |
| (10) BYU @ (8) Colorado | 7:00 PM | |
| (11) San Diego State @ Oregon State | 9:00 PM | USA Net |
January 14
| (NFO) Auburn @ (10) Florida | 5:00 PM | |
| Boston College @ (12) Syracuse | 5:00 PM | |
| (FFO) Stanford @ Wake Forest | 5:00 PM | |
| (6) Georgia @ (6) Tennessee | 5:30 PM | |
| Georgia Tech @ (3) Notre Dame | 6:00 PM | |
| (4) Louisville @ Pittsburgh | 6:00 PM | |
| (4) Virginia @ (10) Miami (FL) | 6:00 PM | |
| (8) California @ (5) Duke | 6:00 PM | |
| (7) Virginia Tech @ (7) North Carolina State | 6:00 PM | |
| (FFO) Missouri @ (8) Ole Miss | 6:00 PM | |
| (12) Wisconsin @ Purdue | 6:00 PM | BTN |
| (NFO) Clemson @ SMU | 6:00 PM | |
| (2) Oklahoma @ (1) South Carolina | 6:30 PM | ESPN |
| (NFO) Arkansas @ (3) Kentucky | 6:30 PM | SEC Network |
| Saint John's @ (FFO) Creighton | 6:30 PM | |
| (7) Alabama @ (1) Texas | 7:00 PM | |
| (7) Mississippi State @ (1) LSU | 7:00 PM | |
| Northwestern @ (6) Iowa | 7:00 PM | |
| (5) Baylor @ (3) TCU | 8:00 PM | |
| (5) Maryland @ (11) Washington | 8:00 PM | BTN |
| Texas A&M @ (2) Vanderbilt | 8:30 PM | SEC Network |
January 15
| Penn State @ (1) UCLA | 9:00 PM | |
| (6) Minnesota @ (4) USC | 9:00 PM |
January 16
| (10) Columbia @ Brown | 12:00 PM | |
| Central Michigan @ (11) Miami (OH) | 12:00 PM | |
| (4) Oklahoma State @ (10) BYU | 1:00 PM | CBSSN |
| (FFO) Princeton @ (NFO) Harvard | 1:00 PM | |
| Mount Saint Mary's @ (12) Fairfield | 1:00 PM | |
| (10) Kansas State @ (11) Iowa State | 2:00 PM | |
| (12) Rice @ UTSA | 2:00 PM | |
| (5) Texas Tech @ (10) Arizona State | 3:00 PM | |
| (11) San Diego State @ Colorado State | 8:00 PM | CW |
January 17
| (3) Ohio State @ (9) Nebraska | 0:00 | Fox |
| (FFO) Stanford @ (5) Duke | 11:00 AM | ACC Network |
| (2) Vanderbilt @ (1) Texas | 12:00 PM | ABC |
| (FFO) Creighton @ Providence | 12:00 PM | |
| (1) LSU @ (NFO) Arkansas | 1:00 PM | SEC Network |
| (4) Louisville @ (7) Virginia Tech | 1:00 PM | CW |
| (4) Virginia @ (NFO) Clemson | 1:00 PM | ACC Network |
| (8) Colorado @ Cincinnati | 1:00 PM | |
| (8) California @ Wake Forest | 1:00 PM | |
| (12) Florida State @ (10) Miami (FL) | 1:00 PM | |
| (3) Notre Dame @ (12) Syracuse | 2:00 PM | |
| (8) Michigan State @ (9) Illinois | 2:00 PM | |
| Northwestern @ (12) Wisconsin | 2:00 PM | |
| (1) South Carolina @ (FFO) Missouri | 3:00 PM | SEC Network |
| Rutgers @ (2) Michigan | 3:00 PM | BTN |
| (3) TCU @ Arizona | 3:00 PM | |
| (9) West Virginia @ (5) Baylor | 4:00 PM | |
| (5) Maryland @ (11) Oregon | 4:00 PM | |
| Purdue @ (11) Washington | 4:00 PM | |
| (9) Indiana @ (6) Iowa | 5:00 PM | BTN |
| Boston College @ (11) North Carolina | 5:00 PM | ACC Network |
January 18
| (1) UCLA v. (2) Oklahoma | 11:00 AM | Fox |
| (12) Fairfield @ Canisius | 12:00 PM | |
| (10) Columbia @ Yale | 1:00 PM | |
| Penn @ (NFO) Harvard | 1:00 PM | |
| (2) Connecticut @ Seton Hall | 1:30 PM | Fox |
| Penn State @ (4) USC | 3:00 PM | BTN |
| (7) North Carolina State @ Georgia Tech | 3:00 PM | |
| (FFO) Princeton @ Dartmouth | 5:00 PM | |
| (6) Tennessee @ (10) Florida | 6:00 PM | SEC Network |
January 19
| (4) Oklahoma State @ Utah | 8:00 PM |
January 20
| (12) Villanova @ Georgetown | 10:00 AM | |
| (11) Washington @ (8) Michigan State | 5:30 PM | |
| (3) TCU @ (10) Arizona State | 6:00 PM | CBSSN |
| (5) Baylor @ (5) Texas Tech | 6:00 PM | |
| (8) Colorado @ (9) West Virginia | 6:00 PM | |
| (12) Rice @ UAB | 6:00 PM | |
| (11) Miami (OH) @ Toledo | 6:00 PM | |
| Houston @ (10) Kansas State | 6:30 PM | |
| (11) Iowa State @ Kansas | 6:30 PM | |
| Xavier @ (FFO) Creighton | 6:30 PM | |
| (2) Michigan @ (9) Illinois | 7:00 PM | Peacock |
| (9) Nebraska @ Northwestern | 7:00 PM | |
| Purdue @ (11) Oregon | 9:00 PM |
January 21
| Gonzaga @ (11) San Diego State | 0:00 | |
| Wake Forest @ (4) Virginia | 5:00 PM | |
| (5) Duke @ Boston College | 5:00 PM | ACC Network |
| Pittsburgh @ (12) Florida State | 5:00 PM | |
| (12) Fairfield @ Rider | 5:00 PM | |
| (NFO) Arkansas @ (6) Georgia | 5:30 PM | |
| (10) Florida @ (1) South Carolina | 6:00 PM | |
| (1) UCLA @ Rutgers | 6:00 PM | |
| (1) LSU @ (7) Alabama | 6:00 PM | |
| (3) Ohio State @ (5) Maryland | 6:00 PM | FS1 |
| (3) Notre Dame @ (4) Louisville | 6:00 PM | ESPN |
| (8) Ole Miss @ (NFO) Auburn | 6:00 PM | SEC Network |
| (10) Miami (FL) @ (NFO) Clemson | 6:00 PM | |
| (2) Oklahoma @ (7) Mississippi State | 6:30 PM | |
| (2) Vanderbilt @ (FFO) Missouri | 6:30 PM | |
| (6) Tennessee @ (3) Kentucky | 7:00 PM | ESPNU |
| (11) North Carolina @ (8) California | 7:00 PM | ACC Network |
| (12) Wisconsin @ (6) Minnesota | 7:30 PM | BTN |
| (1) Texas @ Texas A&M | 8:00 PM | SEC Network |
| (12) Syracuse @ (FFO) Stanford | 9:00 PM |
January 23
| (11) Miami (OH) @ Ohio | 12:00 PM | |
| (9) Illinois @ Northwestern | 1:00 PM | |
| (11) Iowa State @ (9) West Virginia | 1:00 PM | |
| (10) Columbia @ Dartmouth | 1:00 PM | |
| Providence @ (12) Villanova | 1:00 PM | |
| Brown @ (FFO) Princeton | 1:00 PM | |
 Quinnipiac @ (12) Fairfield | 1:00 PM | |
| Cornell @ (NFO) Harvard | 3:00 PM | |
| (11) Washington @ (2) Michigan | 4:00 PM | Peacock |
| Utah @ (5) Baylor | 5:00 PM | |
| (5) Texas Tech @ UCF | 5:00 PM | |
| Cincinnati @ (4) Oklahoma State | 6:30 PM | |
| (10) BYU @ (3) TCU | 7:00 PM | FS1 |
January 24
| Tulsa @ (12) Rice | 0:00 | |
| (1) UCLA @ (5) Maryland | 11:00 AM | BTN |
| (2) Connecticut @ Saint John's | 11:00 AM | TNT |
| (4) USC @ Purdue | 11:00 AM | |
| (NFO) Clemson @ (5) Duke | 11:00 AM | |
| Wake Forest @ (7) North Carolina State | 11:00 AM | ACC Network |
(11) San Diego State @  Texas State | 11:00 AM | CW |
| (7) Alabama @ (6) Tennessee | 12:00 PM | SEC Network |
| (FFO) Creighton @ Butler | 12:00 PM | |
| (3) Kentucky @ (2) Oklahoma | 1:00 PM | |
| (6) Minnesota @ (3) Ohio State | 1:00 PM | BTN |
| (4) Louisville @ SMU | 1:00 PM | CW |
| (4) Virginia @ Pittsburgh | 1:00 PM | |
| (12) Florida State @ (7) Virginia Tech | 1:00 PM | ACC Network |
| (9) Indiana @ (8) Michigan State | 1:00 PM | |
| (10) Arizona State @ (10) Kansas State | 1:00 PM | |
| (11) North Carolina @ (FFO) Stanford | 1:00 PM | |
| (6) Georgia @ (2) Vanderbilt | 2:00 PM | |
| (10) Florida @ (8) Ole Miss | 2:00 PM | SEC Network |
| Kansas @ (8) Colorado | 2:00 PM | |
| Rutgers @ (12) Wisconsin | 2:00 PM | |
| Texas A&M @ (NFO) Auburn | 2:00 PM | |
| (1) Texas @ (7) Mississippi State | 4:00 PM | SEC Network |
| (6) Iowa @ (11) Oregon | 5:00 PM | BTN |
| (12) Syracuse @ (8) California | 5:00 PM | ACC Network |
January 26
| (9) Nebraska @ (9) Illinois | 6:00 PM |
January 27
| Penn State @ (2) Michigan | 5:00 PM | |
| (10) Kansas State @ Cincinnati | 5:30 PM | |
| (4) USC @ (9) Indiana | 6:00 PM | Peacock |
| (9) West Virginia @ (5) Texas Tech | 6:00 PM | |
| Western Michigan @ (11) Miami (OH) | 6:00 PM | |
| (10) Arizona State @ Kansas | 6:30 PM | |
| Houston @ (11) Iowa State | 6:30 PM | |
| (12) Rice @ Tulane | 6:30 PM | |
| (6) Iowa @ (11) Washington | 8:00 PM | Peacock |
| UCF @ (10) BYU | 8:00 PM |
January 28
| (3) Notre Dame @ (11) North Carolina | 5:00 PM | ESPN |
| (8) California @ (4) Virginia | 5:00 PM | |
| (6) Georgia @ (10) Florida | 5:00 PM | |
| (7) Virginia Tech @ Boston College | 5:00 PM | |
| (10) Miami (FL) @ (12) Syracuse | 5:00 PM | |
| (NFO) Clemson @ Pittsburgh | 5:00 PM | ACC Network |
| (1) South Carolina @ (6) Tennessee | 5:30 PM | SEC Network |
| DePaul @ (2) Connecticut | 5:30 PM | FS1 |
| Northwestern @ (3) Ohio State | 5:30 PM | |
| (FFO) Stanford @ (4) Louisville | 6:00 PM | |
| (5) Maryland @ (12) Wisconsin | 6:00 PM | BTN |
| (8) Michigan State @ Rutgers | 6:00 PM | |
| (FFO) Creighton @ Marquette | 6:00 PM | Peacock |
| (7) Mississippi State @ (NFO) Arkansas | 6:30 PM | |
| (7) North Carolina State @ SMU | 6:30 PM | |
| (FFO) Missouri @ (1) Texas | 7:00 PM | |
| (NFO) Auburn @ (1) LSU | 7:00 PM | |
| (3) TCU @ (4) Oklahoma State | 7:00 PM | |
| (5) Duke @ (12) Florida State | 7:00 PM | ACC Network |
| (8) Ole Miss @ Texas A&M | 7:00 PM | |
| (7) Alabama @ (3) Kentucky | 7:30 PM | SEC Network |
| Saint John's @ (12) Villanova | 7:30 PM | FS1 |
| (2) Vanderbilt @ (2) Oklahoma | 8:00 PM | ESPN2 |
| (11) Oregon @ (6) Minnesota | 8:00 PM | BTN |
January 29
| Penn @ (10) Columbia | 0:00 | |
| (FFO) Princeton @ Cornell | 0:00 | |
| (NFO) Harvard @ Brown | 6:00 PM |
January 30
| (FFO) Princeton @ (10) Columbia | 0:00 | |
| Cincinnati @ (9) West Virginia | 1:00 PM | |
| (12) Fairfield @ Mount Saint Mary's | 1:00 PM | |
| (9) Illinois @ (1) UCLA | 2:00 PM | Peacock |
| (11) Iowa State @ (5) Baylor | 3:00 PM | FS1 |
| Arizona @ (10) Arizona State | 3:00 PM | |
| (NFO) Harvard @ Yale | 4:00 PM | |
| (2) Michigan @ (4) USC | 4:30 PM | Fox |
| (10) BYU @ (5) Texas Tech | 7:30 PM |
January 31
| Providence @ (2) Connecticut | 11:00 AM | TNT |
| (7) Mississippi State @ (6) Georgia | 11:00 AM | SEC Network |
| SMU @ (10) Miami (FL) | 11:00 AM | ACC Network |
| (3) Ohio State @ Penn State | 12:00 PM | |
| (FFO) Stanford @ (3) Notre Dame | 12:00 PM | CW |
| (12) Villanova @ Xavier | 12:00 PM | |
| (2) Oklahoma @ Texas A&M | 1:00 PM | SEC Network |
| (8) Colorado @ (3) TCU | 1:00 PM | |
| (8) California @ (7) Virginia Tech | 1:00 PM | ACC Network |
| (11) Oregon @ (9) Nebraska | 1:00 PM | BTN |
| Purdue @ (9) Indiana | 1:00 PM | |
| Wake Forest @ (12) Florida State | 1:00 PM | |
| Seton Hall @ (FFO) Creighton | 1:00 PM | |
| (3) Kentucky @ (1) South Carolina | 2:00 PM | ESPN |
| (4) Oklahoma State @ Houston | 2:00 PM | |
| (12) Wisconsin @ (6) Iowa | 2:00 PM | |
| (10) Kansas State @ Kansas | 2:00 PM | |
| Colorado State @ (11) San Diego State | 2:00 PM | CW |
 Charlotte @ (12) Rice | 2:00 PM | |
| Ball State @ (11) Miami (OH) | 3:00 PM | |
| (NFO) Arkansas @ (NFO) Auburn | 3:00 PM | SEC Network |
| (5) Duke @ (11) North Carolina | 4:00 PM | ESPN |
| (12) Syracuse @ Georgia Tech | 5:00 PM | ACC Network |
February 1
| (4) Virginia @ (7) North Carolina State | 5:00 PM | ESPN2 |
| (8) Michigan State @ (5) Maryland | 6:00 PM | BTN |
| (FFO) Missouri @ (7) Alabama | 6:00 PM | SEC Network |
| (8) Ole Miss @ (1) LSU | 7:00 PM | ESPN2 |
February 2
| (2) Michigan @ (1) UCLA | 9:00 PM | FS1 |
| (9) Illinois @ (4) USC | 9:00 PM | Peacock |
February 3
| (11) San Diego State @ Washington State | 0:00 | |
| (11) Miami (OH) @ Central Michigan | 5:30 PM | |
| (3) Ohio State @ (9) Indiana | 6:00 PM | |
| (5) Texas Tech @ (11) Iowa State | 6:30 PM | |
| Cincinnati @ (5) Baylor | 7:00 PM | |
| Houston @ (8) Colorado | 7:00 PM | |
| (10) BYU @ Utah | 8:00 PM | |
| (9) West Virginia @ (10) Arizona State | 9:00 PM |
February 4
| (4) Louisville @ Wake Forest | 5:00 PM | |
| (5) Maryland @ Purdue | 5:00 PM | BTN |
| (7) Virginia Tech @ (NFO) Clemson | 5:00 PM | ACC Network |
| (4) Oklahoma State @ UCF | 5:30 PM | |
| (1) South Carolina @ (2) Vanderbilt | 6:00 PM | ESPN |
| (1) Texas @ (NFO) Auburn | 6:00 PM | SEC Network |
| (2) Connecticut @ Butler | 6:00 PM | truTV |
| (7) Alabama @ (2) Oklahoma | 6:00 PM | |
| Pittsburgh @ (7) North Carolina State | 6:00 PM | |
| (11) North Carolina @ (10) Miami (FL) | 6:00 PM | |
| Sacred Heart @ (12) Fairfield | 6:00 PM | |
| (6) Tennessee @ (7) Mississippi State | 6:30 PM | |
| (6) Minnesota @ (12) Wisconsin | 6:30 PM | |
| (10) Florida @ (FFO) Missouri | 6:30 PM | |
| Texas A&M @ (NFO) Arkansas | 6:30 PM | |
| (1) LSU @ (3) Kentucky | 7:00 PM | ESPN2 |
| SMU @ (3) Notre Dame | 7:00 PM | ACC Network |
| (3) TCU @ (10) Kansas State | 7:00 PM | FS1 |
| (6) Iowa @ (9) Nebraska | 7:30 PM | Peacock |
| (6) Georgia @ (8) Ole Miss | 8:00 PM | SEC Network |
| (12) Florida State @ (8) California | 8:00 PM | |
| (12) Villanova @ DePaul | 8:00 PM | truTV |
| (11) Washington @ (11) Oregon | 9:00 PM | BTN |
| Georgia Tech @ (FFO) Stanford | 9:00 PM |
February 6
| Cornell @ (10) Columbia | 0:00 | |
| (FFO) Princeton @ Penn | 1:00 PM | |
| Georgetown @ (FFO) Creighton | 1:00 PM | |
| (NFO) Harvard @ Dartmouth | 1:00 PM | |
| (12) Fairfield @ Saint Peter's | 1:00 PM | |
| (8) Colorado @ (11) Iowa State | 2:00 PM | |
| Memphis @ (12) Rice | 2:00 PM | |
| Kansas @ (10) BYU | 3:00 PM | |
| (9) West Virginia @ Arizona | 8:00 PM | |
| (11) San Diego State @ Gonzaga | 10:00 PM | CW |
February 7
| (6) Tennessee @ (2) Vanderbilt | 0:00 | ESPN |
| (6) Iowa @ (2) Michigan | 11:00 AM | Fox |
| (3) Kentucky @ (6) Georgia | 11:00 AM | SEC Network |
| (3) Notre Dame @ (NFO) Clemson | 11:00 AM | |
| (7) North Carolina State @ (12) Syracuse | 11:00 AM | ACC Network |
| (9) Nebraska @ Purdue | 11:00 AM | |
| Seton Hall @ (12) Villanova | 11:30 AM | TNT |
| (8) Michigan State @ (3) Ohio State | 12:00 PM | |
| (5) Maryland @ Penn State | 12:00 PM | |
| (1) LSU @ (FFO) Missouri | 1:00 PM | SEC Network |
| (4) Louisville @ (4) Virginia | 1:00 PM | |
| (5) Baylor @ UCF | 1:00 PM | |
| (5) Texas Tech @ (10) Kansas State | 1:00 PM | |
| (10) Miami (FL) @ (5) Duke | 1:00 PM | CW |
| (7) Virginia Tech @ (11) North Carolina | 1:00 PM | ACC Network |
| (2) Connecticut @ Marquette | 1:30 PM | TNT |
| Houston @ (3) TCU | 2:00 PM | |
| Rutgers @ (6) Minnesota | 2:00 PM | |
| (10) Florida @ Texas A&M | 2:00 PM | |
| (8) Ole Miss @ (7) Mississippi State | 3:00 PM | SEC Network |
| Northwestern @ (9) Illinois | 3:00 PM | BTN |
| (12) Florida State @ (FFO) Stanford | 3:00 PM | ACC Network |
| (10) Arizona State @ (4) Oklahoma State | 5:00 PM | |
| (NFO) Auburn @ (7) Alabama | 5:00 PM | SEC Network |
| Georgia Tech @ (8) California | 5:00 PM | ACC Network |
| (9) Indiana @ (11) Washington | 5:00 PM | BTN |
| (4) USC @ (1) UCLA | 7:00 PM | Fox |
February 8
| (1) South Carolina @ (2) Oklahoma | 6:00 PM | ESPN2 |
| (NFO) Arkansas @ (1) Texas | 6:30 PM | SEC Network |
February 9
| Utah @ (9) West Virginia | 6:00 PM | |
| (12) Rice @ Wichita State | 6:00 PM |
February 10
 Fresno State @ (11) San Diego State | 0:00 | |
| (12) Villanova @ (2) Connecticut | 5:00 PM | Peacock |
| (11) Washington @ (3) Ohio State | 5:30 PM | |
| (11) Iowa State @ Cincinnati | 5:30 PM | |
| Kent State @ (11) Miami (OH) | 6:00 PM | |
| DePaul @ (FFO) Creighton | 6:30 PM | |
| (10) Kansas State @ (5) Baylor | 7:00 PM | |
| (10) Arizona State @ Houston | 7:00 PM | |
| (3) TCU @ Kansas | 8:00 PM | CBSSN |
| Arizona @ (10) BYU | 8:00 PM | |
| (9) Indiana @ (11) Oregon | 9:00 PM | |
| (4) Oklahoma State @ (8) Colorado | 9:30 PM | FS1 |
February 11
| Texas A&M @ (1) South Carolina | 5:00 PM | SEC Network |
| (4) Virginia @ (3) Notre Dame | 5:00 PM | ESPN2 |
| (12) Syracuse @ (4) Louisville | 5:00 PM | ACC Network |
| (7) Mississippi State @ (10) Florida | 5:00 PM | |
| SMU @ (7) Virginia Tech | 5:00 PM | |
| Purdue @ (8) Michigan State | 5:00 PM | BTN |
| (NFO) Clemson @ (12) Florida State | 5:00 PM | |
| (NFO) Auburn @ (6) Tennessee | 5:30 PM | |
| (FFO) Missouri @ (6) Georgia | 5:30 PM | |
| (1) Texas @ (1) LSU | 6:00 PM | ESPN |
| (3) Kentucky @ (8) Ole Miss | 6:00 PM | |
| (4) USC @ (6) Iowa | 6:00 PM | FS1 |
| Boston College @ (7) North Carolina State | 6:00 PM | |
| Wake Forest @ (10) Miami (FL) | 6:00 PM | |
 Marist @ (12) Fairfield | 6:00 PM | |
| (2) Oklahoma @ (NFO) Arkansas | 6:30 PM | |
| (5) Duke @ Georgia Tech | 7:00 PM | ACC Network |
| (6) Minnesota @ (9) Nebraska | 7:00 PM | BTN |
| (2) Vanderbilt @ (7) Alabama | 7:30 PM | SEC Network |
| (1) UCLA @ (12) Wisconsin | 8:00 PM | FS1 |
| (8) California @ (FFO) Stanford | 9:00 PM |
February 12
| (10) Columbia @ Penn | 5:00 PM | |
| Northwestern @ (2) Michigan | 6:00 PM | |
| Cornell @ (FFO) Princeton | 6:00 PM | |
| Brown @ (NFO) Harvard | 6:00 PM |
February 13
| Xavier @ (2) Connecticut | 11:00 AM | FS1 |
| (11) Washington @ Penn State | 12:00 PM | |
| UCF @ (5) Texas Tech | 12:30 PM | |
| (12) Villanova @ Butler | 1:00 PM | |
| (11) Miami (OH) @ Eastern Michigan | 1:00 PM | |
| (12) Fairfield @ Quinnipiac | 1:00 PM | |
| Cincinnati @ (10) Arizona State | 1:30 PM | |
| (11) Oregon @ (9) Illinois | 2:00 PM | |
| (12) Rice @ Tulsa | 2:00 PM | |
| (5) Baylor @ Arizona | 3:00 PM | |
| (10) Columbia @ (FFO) Princeton | 4:00 PM | |
| Yale @ (NFO) Harvard | 5:00 PM | |
| (8) Colorado @ Utah | 6:00 PM | |
| (10) BYU @ (11) Iowa State | 6:00 PM |
February 14
| (11) San Diego State @ Boise State | 0:00 | |
| (FFO) Creighton @ Saint John's | 10:00 AM | truTV |
| (2) Oklahoma @ (10) Florida | 11:00 AM | SEC Network |
| (9) Nebraska @ (5) Maryland | 11:00 AM | BTN |
| Pittsburgh @ (5) Duke | 11:00 AM | |
| (NFO) Clemson @ Boston College | 11:00 AM | |
| (1) South Carolina @ (8) Ole Miss | 12:00 PM | ESPNU |
| (1) UCLA @ (6) Iowa | 1:00 PM | Fox |
| Wake Forest @ (3) Notre Dame | 1:00 PM | |
| Georgia Tech @ (4) Louisville | 1:00 PM | |
| (4) Virginia @ (12) Syracuse | 1:00 PM | |
| (6) Tennessee @ (FFO) Missouri | 1:00 PM | SEC Network |
| (6) Minnesota @ (8) Michigan State | 1:00 PM | |
| (12) Wisconsin @ (9) Indiana | 1:00 PM | |
| (10) Miami (FL) @ (12) Florida State | 1:00 PM | |
| (11) North Carolina @ SMU | 1:00 PM | |
| (6) Georgia @ (1) LSU | 2:00 PM | |
| (7) Alabama @ (NFO) Arkansas | 2:00 PM | |
| Texas A&M @ (1) Texas | 3:00 PM | SEC Network |
February 15
| (10) Kansas State @ (4) Oklahoma State | 12:00 PM | Fox |
| (9) West Virginia @ (3) TCU | 2:00 PM | Fox |
| (2) Vanderbilt @ (3) Kentucky | 5:00 PM | ESPN2 |
| (7) Mississippi State @ (NFO) Auburn | 7:00 PM | SEC Network |
February 16
| (11) Oregon @ Northwestern | 7:00 PM | |
| (8) Colorado @ (10) BYU | 8:00 PM | |
| (5) Baylor @ (10) Arizona State | 9:00 PM | FS1 |
February 17
| Oregon State @ (11) San Diego State | 0:00 | |
| Houston @ (5) Texas Tech | 6:00 PM | |
| (9) Illinois @ (5) Maryland | 6:00 PM | |
| (9) Indiana @ Purdue | 6:00 PM | |
 Bowling Green @ (11) Miami (OH) | 6:00 PM | |
| Utah @ (11) Iowa State | 6:30 PM | |
| (2) Michigan @ (6) Minnesota | 7:00 PM | |
| (12) Wisconsin @ (9) Nebraska | 7:00 PM | |
| East Carolina @ (12) Rice | 7:00 PM | |
| Rutgers @ (11) Washington | 9:00 PM |
February 18
| (12) Florida State @ (4) Virginia | 5:00 PM | |
| (6) Iowa @ Penn State | 5:00 PM | BTN |
| (FFO) Stanford @ (7) Virginia Tech | 5:00 PM | |
| (11) North Carolina @ Pittsburgh | 5:00 PM | ACC Network |
| (12) Syracuse @ Boston College | 5:00 PM | |
| (2) Connecticut @ Georgetown | 6:00 PM | Peacock |
| (4) Louisville @ (5) Duke | 6:00 PM | ESPN |
| Canisius @ (12) Fairfield | 6:00 PM | |
| Providence @ (FFO) Creighton | 6:30 PM | |
| (3) Notre Dame @ (7) North Carolina State | 7:00 PM | ESPN2 |
| (8) California @ (NFO) Clemson | 7:00 PM | ACC Network |
| Marquette @ (12) Villanova | 7:00 PM | Peacock |
| (8) Michigan State @ (4) USC | 9:00 PM | Peacock |
| (3) Ohio State @ (1) UCLA | 9:30 PM | BTN |
February 20
| Dartmouth @ (10) Columbia | 0:00 | |
| (NFO) Harvard @ Cornell | 0:00 | |
| (10) BYU @ Cincinnati | 11:00 AM | |
| (2) Michigan @ (12) Wisconsin | 12:00 PM | BTN |
| (FFO) Princeton @ Brown | 12:00 PM | |
| (3) TCU @ Houston | 1:00 PM | |
| (5) Texas Tech @ (9) West Virginia | 1:00 PM | |
| (11) Iowa State @ UCF | 1:00 PM | |
| (12) Rice @ South Florida | 1:00 PM | |
| Niagara @ (12) Fairfield | 1:00 PM | |
| Arizona @ (8) Colorado | 2:00 PM | |
| (11) Washington @ (6) Minnesota | 3:00 PM | FS1 |
| (11) Miami (OH) @ Akron | 3:00 PM | |
| Rutgers @ (11) Oregon | 8:00 PM |
February 21
| Washington State @ (11) San Diego State | 0:00 | |
| Saint John's @ (2) Connecticut | 11:00 AM | FS1 |
| (8) Ole Miss @ (2) Vanderbilt | 11:00 AM | ESPN |
| (12) Florida State @ (11) North Carolina | 11:00 AM | CW |
| (3) Kentucky @ (6) Tennessee | 12:00 PM | SEC Network |
| (5) Maryland @ Northwestern | 12:00 PM | BTN |
| (3) Notre Dame @ Boston College | 1:00 PM | |
| (7) North Carolina State @ (4) Louisville | 1:00 PM | ESPN |
| (FFO) Stanford @ (4) Virginia | 1:00 PM | ACC Network |
| Purdue @ (6) Iowa | 1:00 PM | |
| (7) Virginia Tech @ Georgia Tech | 1:00 PM | |
| (9) Illinois @ (9) Indiana | 1:00 PM | FS1 |
| (10) Miami (FL) @ Pittsburgh | 1:00 PM | |
| (FFO) Creighton @ (12) Villanova | 1:00 PM | truTV |
| (1) LSU @ (1) South Carolina | 2:00 PM | ABC |
| (8) Michigan State @ (1) UCLA | 2:00 PM | BTN |
| (10) Florida @ (1) Texas | 2:00 PM | SEC Network |
| (NFO) Auburn @ (2) Oklahoma | 2:00 PM | |
| (7) Alabama @ (7) Mississippi State | 2:00 PM | |
| (8) California @ SMU | 2:00 PM | |
| Penn State @ (9) Nebraska | 2:00 PM | |
| (3) Ohio State @ (4) USC | 3:00 PM | NBC |
| (4) Oklahoma State @ (5) Baylor | 3:00 PM | |
| (10) Arizona State @ Utah | 3:00 PM | |
| (NFO) Arkansas @ (FFO) Missouri | 4:00 PM | SEC Network |
| (5) Duke @ Wake Forest | 5:00 PM | ACC Network |
| Kansas @ (10) Kansas State | 5:00 PM | CBSSN |
February 22
| (12) Syracuse @ (NFO) Clemson | 5:00 PM | ESPN2 |
| (6) Georgia @ Texas A&M | 6:00 PM | SEC Network |
February 23
| (10) BYU @ (9) West Virginia | 6:00 PM | |
| UCF @ (3) TCU | 6:30 PM |
February 24
| (11) San Diego State @ Utah State | 0:00 | |
| (11) Miami (OH) @ UMass | 5:00 PM | |
| (9) Indiana @ (2) Michigan | 5:30 PM | Peacock |
| (4) Oklahoma State @ (5) Texas Tech | 5:30 PM | CBSSN |
| (FFO) Creighton @ Xavier | 5:30 PM | |
| Purdue @ (3) Ohio State | 6:00 PM | |
| (9) Nebraska @ Rutgers | 6:00 PM | |
| Kansas @ (11) Iowa State | 6:30 PM | |
| Temple @ (12) Rice | 7:00 PM | |
| (8) Colorado @ (10) Arizona State | 7:30 PM |
February 25
| (1) LSU @ (6) Tennessee | 5:00 PM | ESPN |
| (5) Duke @ SMU | 5:00 PM | ACC Network |
| (7) North Carolina State @ Wake Forest | 5:00 PM | |
| (12) Wisconsin @ (8) Michigan State | 5:00 PM | |
| (12) Fairfield @ Iona | 5:00 PM | |
| (NFO) Auburn @ (1) South Carolina | 6:00 PM | |
| (2) Connecticut @ Providence | 6:00 PM | TNT |
| (10) Florida @ (6) Georgia | 6:00 PM | SEC Network |
| (7) Virginia Tech @ (10) Miami (FL) | 6:00 PM | |
| Georgia Tech @ (NFO) Clemson | 6:00 PM | |
| (FFO) Missouri @ (2) Vanderbilt | 6:30 PM | |
| (5) Maryland @ (6) Iowa | 6:30 PM | Peacock |
| (NFO) Arkansas @ (7) Mississippi State | 6:30 PM | |
| (1) Texas @ (2) Oklahoma | 7:00 PM | ESPN2 |
| (3) Kentucky @ Texas A&M | 7:00 PM | |
| (4) Virginia @ (11) North Carolina | 7:00 PM | ACC Network |
| (6) Minnesota @ Northwestern | 7:00 PM | |
| (5) Baylor @ (10) Kansas State | 7:30 PM | FS1 |
| Penn State @ (9) Illinois | 7:30 PM | BTN |
| (8) Ole Miss @ (7) Alabama | 8:00 PM | SEC Network |
| Boston College @ (8) California | 8:00 PM | |
| (1) UCLA @ (4) USC | 8:30 PM | Peacock |
| Pittsburgh @ (FFO) Stanford | 9:00 PM | |
| (11) Oregon @ (11) Washington | 9:30 PM | BTN |
February 26
| Brown @ (10) Columbia | 0:00 | |
| (NFO) Harvard @ (FFO) Princeton | 6:00 PM |
February 27
| Yale @ (10) Columbia | 0:00 | |
| (11) San Diego State @ Fresno State | 0:00 | |
| (9) Nebraska @ (9) Indiana | 11:00 AM | BTN |
| Marquette @ (FFO) Creighton | 11:30 AM | Fox |
| Buffalo @ (11) Miami (OH) | 12:00 PM | |
| (9) West Virginia @ Cincinnati | 1:00 PM | |
| (12) Fairfield @ Sacred Heart | 1:00 PM | |
| (11) Iowa State @ (4) Oklahoma State | 1:30 PM | FS1 |
| UTSA @ (12) Rice | 2:00 PM | |
| Utah @ (10) BYU | 3:00 PM | |
| (NFO) Harvard @ Penn | 3:00 PM | |
| (12) Villanova @ Seton Hall | 4:00 PM | Peacock |
| Dartmouth @ (FFO) Princeton | 4:00 PM |
February 28
| (1) South Carolina @ (6) Georgia | 11:00 AM | SEC Network |
| (6) Iowa @ (3) Ohio State | 11:00 AM | Fox |
| (4) Louisville @ (3) Notre Dame | 11:00 AM | ESPN |
| Rutgers @ (5) Maryland | 11:00 AM | BTN |
| (NFO) Clemson @ (7) North Carolina State | 11:00 AM | CW |
| Wake Forest @ (12) Syracuse | 11:00 AM | ACC Network |
| (2) Michigan @ (8) Michigan State | 12:00 PM | Peacock |
| (2) Vanderbilt @ (10) Florida | 12:00 PM | |
| (12) Wisconsin @ Penn State | 12:00 PM | |
| (1) UCLA @ (11) Washington | 1:00 PM | BTN |
| (1) Texas @ (8) Ole Miss | 1:00 PM | |
| (2) Oklahoma @ (1) LSU | 1:00 PM | |
| Butler @ (2) Connecticut | 1:00 PM | FS1 |
| (7) Mississippi State @ (3) Kentucky | 1:00 PM | SEC Network |
| Pittsburgh @ (8) California | 1:00 PM | ACC Network |
| Georgia Tech @ (10) Miami (FL) | 1:00 PM | |
| SMU @ (12) Florida State | 1:00 PM | |
| (5) Texas Tech @ Kansas | 2:00 PM | |
| (6) Tennessee @ (NFO) Arkansas | 2:00 PM | |
| (9) Illinois @ (6) Minnesota | 2:00 PM | Peacock |
| Texas A&M @ (7) Alabama | 2:00 PM | |
| (10) Kansas State @ (8) Colorado | 2:00 PM | |
| (3) TCU @ (5) Baylor | 3:00 PM | FS1 |
| (4) USC @ (11) Oregon | 3:00 PM | BTN |
| (11) North Carolina @ (5) Duke | 3:00 PM | ESPN |
| (10) Arizona State @ Arizona | 3:00 PM | |
| (FFO) Missouri @ (NFO) Auburn | 3:00 PM | SEC Network |
| Boston College @ (FFO) Stanford | 4:00 PM | |
| (4) Virginia @ (7) Virginia Tech | 5:00 PM | ACC Network |
March 3
| (11) Miami (OH) @ Western Michigan | 6:00 PM | |
| (12) Rice @ North Texas | 6:30 PM |
March 6
| Texas State @ (11) San Diego State | 0:00 | |
| Ohio @ (11) Miami (OH) | 12:00 PM | |
| (10) Columbia @ (NFO) Harvard | 1:00 PM | |
| Yale @ (FFO) Princeton | 1:00 PM | |
| South Florida @ (12) Rice | 2:00 PM |